Progress in Nucleic Acid Research and Molecular Biology
Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 1. January 1966
449 pages
978-0-08-086293-4 (ISBN)
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Progress in Nucleic Acid Research and Molecular Biology
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10/1966
Academic Press
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Content
- Cover
- Contents
- List of Contributors
- Preface
- Abbreviation and Symbols
- Contents of Previous Volumes
- Articles Planned for Future Volumes
- Chapter 1. Introduction to the Biochemistry of D-Arabinosyl Nucleosides
- I. Introduction
- II. Discovery and Structure of the Spongonucleosides
- the 1-ß-D-Arabino- furanosylpyrimidines
- III. Chemical Synthesis of 1-ß-D-Arabinofuranosylpyrimidines
- IV. The Synthesis of D-Arabinofuranosylpurines
- V. The Schramm Synthesis
- VI. The Synthesis of D-Arabinofuranosyl Nucleotides
- VII. Studies on the Sponge, Cryptotethya crypta
- VIII. The Metabolism of the Arabinonucleosides by Bacteria
- IX. The Metabolism of D-Arabinose in Bacteria
- X. Effects of Some Arabinonucleosides of Pyrimidines on Animal Cells
- XI. Effects of 9-ß-D-Arabinofuranosyladenine on Animal Cells and on Bacteria
- XII. Some Effects of Other 9-ß-D-Arabinofuranosylpurines
- XIII. Arabinosyl Nucleotides in Polymer-Synthesizing Systems
- XIV. Discussion
- XV. Addendum"Is Ara-C Incorporated into Nucleic Acid?
- References
- Chapter 2. Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids
- I. Studies of the Reactions of Alkylating Agents with Nucleic Acids and Their Constituent Nucleosides and Nucleotides
- II. The Possible Role of Alkylation of DNA in the Molecular Mechanism of the Radiomimetic Cytotoxic Action of Alkylating Agents
- III. Molecular Mechanisms of the Mutagenic Action of Alkylating Agents
- IV. Alkylation of Nucleic Acids in Vivo by Chemical Carcinogens
- V. Binding of Polynuclear Aromatic Hydrocarbons to Nucleic Acids in Vitro and in Vivo
- VI. Reaction of Metabolites of Carcinogenic Amines with Nucleic Acids
- VII. Addenda
- References
- Chapter 3. Nucleic Acids in Chloroplasts and Metabolic DNA
- I. Introduction
- II. The DNA Content of Chloroplasts
- III. Protein and Nucleic Acid Synthesis
- IV. Minor DNA Components and Metabolic DNA
- V. Summary
- References
- Chapter 4. Enzymatic Alteration of Macromolecular Structure
- I. Introduction
- II. Glucosylation of DNA
- III. Methylation of Nucleic Acids
- IV. Alterations of Protein Structure
- V. Miscellaneous
- VI. Conclusion
- References
- Chapter 5. Hormones and the Synthesis and Utilization of Ribonucleic Acids
- I. Introduction
- II. Some Important Features of Hormone Action
- III. Hormones and Protein Synthesis
- IV. Hormonal Control of RNA Synthesis
- V. Sequence of Hormonal Effects on RNA and Protein Synthesis
- VI. Effects of Inhibitors of RNA and Protein Synthesis on Hormonal Activity
- VII. The Role of Hormones in RNA Transport and Utilization
- VIII. Concluding Remarks
- References
- Chapter 6. Nucleoside Antibiotics
- I. Introduction
- II. Purine Nucleoside Antibiotics
- III. Pyrimidine Nucleoside Antibiotics
- IV. Miscellaneous Antibiotics
- V. Other Naturally Occurring Nucleosides
- VI. Biological and Biochemical Properties of the Nucleoside Antibiotics
- VII. Addendum
- References
- Chapter 7. Recombination of DNA Molecules
- I. Introduction
- II. Breakage and Rejoining
- III. Homologous Pairing
- IV. Nonrepeating Nucleoside Sequences
- V. Consequences of Repetitious Recognition Lengths
- VI. Consequences of Nonrepetition
- VII. Conclusions
- References
- Appendix I: Recombination of a Pool of DNA Fragments with Complementary Single-Chain Ends
- Appendix II: Proof That Sequences of A,C,G, and T Can Be Assembled to Produce Chains of Ultimate Length Avoiding Repetitions Everywhere
- I. Definition of Blocks
- II. Results to Be Proved
- III. Definitions and Results from Graph Theory
- IV. Proof of Results Stated in Section II
- Chapter 8. The Chemistry of Pseudouridine
- I. Introduction
- II. Structure
- III. Properties
- IV. Attempts to Cleave tRNA at Its Pseudouridylate Residues
- V. Isolation and Synthesis of Pseudouridine and Some Derivatives
- VI. Conclusions
- References
- Chapter 9. The Biochemistry of Pseudouridine
- I. Introduction
- II. The Occurrence of Pseudouridine in Biological Systems
- III. Enzyme Reactions Involving Pseudouridine and Its Derivatives
- IV. The Biological Role of Pseudouridine and Its Biosynthesis
- V. Conclusions
- References
- Index
- Subject Index
- Author Index
