Progress in Nucleic Acid Research and Molecular Biology
Academic Press
Published on 1. January 1965
293 pages
978-0-08-086292-7 (ISBN)
Description
Progress in Nucleic Acid Research and Molecular Biology
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12/1963
Academic Press
€96.11
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Content
- Cover
- Contents
- List of Contributors
- Preface
- Abbreviations and Symbols
- Contents of Volume 1
- Contents of Volume 2
- Contents of Volume 3
- Articles Planned for Future Volumes
- Chapter 1. Fluorinated Pyrimidines
- I. Introduction
- II. Rationale
- III. Syntheses
- IV. Physical and Chemical Properties
- V. Tumor Screening
- VI. Biochemical Summary
- VII. Incorporation into RNA
- VIII. Incorporation into DNA
- IX. Effects on Nucleic Acid Metabolism
- X. Inhibition of Thymidylate Synthetase
- XI. Mechanisms of Cellular Resistance
- XII. Effects on Bacterial Cell Walls
- XIII. Other Biological Effects
- XIV. Effects on Protein Synthesis
- XV. Other Effects in Viral Systems
- XVI. A Proposal to Explain the Mechanism of Action of Fluorouracil Incorporated into RNA
- XVII. Clinical Pharmacology
- XVIII. Clinical Efficacy in Cancer Chemotherapy
- References
- Chapter 2. Genetic Recombination in Bacteriophage
- I. Introduction
- II. Genetic and Biologic Considerations
- III. Biophysical and Biochemical Approaches
- IV. Some Possible Enzyme Functions
- References
- Chapter 3. DNA Polymerases from Mammalian Cells
- I. Introduction
- II. A General Survey of DNA Nucleotidyltransferases from Mammalian Tissues
- III. The Product of the DNA Nucleotidyltransferase Reaction
- IV. The lntracellular Location of DNA Nucleotidyltransferase
- V. The Terminal Addition Reaction
- VI. Miscellaneous Factors Affecting DNA Nucleotidyltransferase
- VII. A Hypothesis for the Mechanism of Action of DNA Nucleotidyltransferase
- VIII. Nonmammalian Systems
- References
- Chapter 4. The Evolution of Base Sequences in Polynucleotides
- I. Introduction
- II. Methods of Approach
- III. Studies of Viral DNA
- IV. Bacterial DNA
- V. The Evolution of Individual Genes
- VI. DNA of Higher Organisms
- VII. Nonchromosornal DNA
- VIII. Conclusions
- References
- Chapter 5. Biosynthesis of Ribosomes in Bacterial Cells
- I. lntroduction
- II. The RNA and Ribosomes of Bacterial Cells
- III. Unusual Particles
- IV. The Process of Ribosome Formation
- V. The Origin of Ribosomal RNA
- VI. The Origin of Ribosomal Protein
- VII. Concluding Remarks
- Notes Added in Proof
- References
- Chapter 6. 5-Hydroxymethylpyrimidines and Their Derivatives
- I. Introduction
- II. Synthesis of Hydroxymethylpyrimidines
- III. Toxopyrimidine
- IV. Hydroxymethylcytosine
- V. Methioprim
- VI. Hydroxymethyluracil
- VII. Pseudouridine
- VIII. Bacimethrin
- Addendum
- References
- Chapter 7. Amino Acid Esters of RNA, Nucleosides, and Related Compounds
- I. Introduction
- II. Amino Acid Esters of tRNA
- III. Amino Acid Esters of Nucleotides and Nucleosides
- IV. Some Properties of the Ester Bond
- V. On the Site of Esterification in Aminoacyl-tRNA and Aminoacyl-Nucleosides
- VI. Peptide Esters of RNA and Related Compounds
- VII. Various Compounds Containing Nucleotides and Amino Acids, Peptides, or Carboxylic Acids
- References
- Chapter 8. Uptake of DNA by Living Cells
- I. Introduction
- II. Attempts to Transform in Vifro
- III. Biochemical Grounds
- IV. Attempts to Transform in Vivo
- V. Attempts to Induce Other Biological Modifleations
- VI. Fate of DNA in living Organisms
- VII. Implications and Working Hypotheses
- VIII. Conclusions
- References
- Index
- Author Index
- Subject Index
