Progress in Medicinal Chemistry
Elsevier (Publisher)
Published on 15. November 2009
264 pages
978-0-08-095086-0 (ISBN)
Description
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.
- Presents the latest research in the field of drug discovery
- Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry
- Available as an online resource via ScienceDirect
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Content
- Front Cover
- Progress in Medicinal Chemistry 48
- Copyright Page
- Contents
- Preface
- List of Contributors
- Chapter 1 Medicinal Chemistry by the Numbers: The Physicochemistry, Thermodynamics and Kinetics of Modern Drug Design
- INTRODUCTION
- PHYSICOCHEMISTRY
- SHAPE
- BINDING
- BINDING KINETICS
- CONCLUSIONS
- REFERENCES
- Chapter 2 The Identification of and Rationale for Drugs Which Act at The Motilin Receptor
- INTRODUCTION
- ADVANCES IN MOTILIN RECEPTOR NEUROPHARMACOLOGY
- MOTILIN RECEPTOR AGONISTS
- MOTILIN RECEPTOR ANTAGONISTS
- CONCLUSIONS
- REFERENCES
- Chapter 3 Progress in the Design and Development of Phosphoinositide 3-Kinase (PI3K) Inhibitors for the Treatment of Chronic Diseases
- INTRODUCTION
- THE PHOSPHOINOSITIDE 3-KINASE (PI3K) FAMILY
- THE PI3K SIGNALLING PATHWAY: DOWN-STREAM TARGETS AND FUNCTIONS
- TARGETING PI3Ks: THERAPEUTIC POTENTIAL OF SMALL MOLECULE INHIBITORS
- CLINICAL LANDSCAPE
- FUTURE PERSPECTIVE
- REFERENCES
- Chapter 4 Progress in the Development of ß-secretase Inhibitors for Alzheimer's Disease
- INTRODUCTION
- ASTEX
- ASTEX/ASTRAZENECA
- GSK
- HOFFMANN-LA ROCHE
- JOHNSON AND JOHNSON
- MERCK
- NOVARTIS
- PFIZER
- SCHERING-PLOUGH
- SUNESIS
- WYETH
- SUMMARY
- REFERENCES
- Chapter 5 Advances in the Design of 5-HT[sub(6)] Receptor Ligands with Therapeutic Potential
- INTRODUCTION
- MEDICINAL CHEMISTRY OF 5-HT[sub(6)] RECEPTOR MODULATION
- CLINICAL ACTIVITIES
- CONCLUSION
- REFERENCES
- Subject Index
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- W
- Cumulative Index of Authors for Volumes 1-48
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- Cumulative Index of Subjects for Volumes 1-48
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- D
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- F
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