Progress in Medicinal Chemistry
Butterworth-Heinemann (Publisher)
Published on 22. September 2011
390 pages
978-0-08-086253-8 (ISBN)
Description
Progress in Medicinal Chemistry
More details
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Content
- Front Cover
- Progress in Medicinal Chemistry, Volume 5
- Copyright Page
- CONTENTS
- Preface
- CHAPTER 1. POLYPEPTIDE ANTIBIOTICS OF MEDICINAL INTEREST
- 1. Introduction
- 2. Classification of peptides
- 3. Techniques of peptide chemistry
- 4. Polypeptide antibiotics produced by B. brevis
- 5. Peptide antibiotics pioduced by B. subtilis and B. licheniformis
- 6. Polypeptide antibiotics produced by other strains of bacilli
- 7. Polypeptide antibiotics produced by streptomyces
- 8. Polypeptide antibiotics produced by fungi
- 9. Polypeptide antibiotics isolated from different sources
- 10. Biosynthesis of polypeptide antibiotics
- 11. Mechanism of action of polypeptide antibiotics
- CHAPTER 2. NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
- 1. Introduction
- 2. The nature and mechanism of inflammation
- 3. Tests for anti-inflammatory activity
- 4. Anti-inflammatory compounds
- 5. Mode of action
- 6. Uncoupling of oxidative phosphorylation
- 7. Inhibition of hyaluronidase
- 8. Stimulation of the adrenal cortex
- 9. Chelation
- 10. Hyperglycaemia
- 11. Effects on immunological processes
- CHAPTER 3. THE PHARMACOLOGY OF HEPARIN AND HEPARINOIDS
- 1. Introduction
- 2. Complexing properties of heparin, heparinoids and mucopolysaccharides
- 3. Biological reactions of heparin and heparinoids
- 4. Anticoagulant activity
- 5. Haemorrhage and thrombosis
- 6. Chemical structure and biological activity
- 7. Absorption, distribution and metabolism
- 8. Toxicity
- 9. Endogenous heparin and heparinoids
- CHAPTER 4. THE HISTIDINE DECARBOXYLASES
- 1. Introduction
- 2. The measurement of histidine decarboxylase activity
- 3. The substrate specificity of histidine decarboxylases
- 4. The distribution of histidine decarboxylases
- 5. The mechanism of action of histidine decarboxylases
- 6. Inhibition of histidine decarboxylation in vitro
- 7. Inhibition of histidine decarboxylation in vivo
- 8. Factors which modify the histidine decarboxylase activity of tissues
- 9. The physiological function of histidine decarboxylases
- 10. Concluding remarks
- CHAPTER 5. PSYCHOT'ROPIC DRUGS AND NEUROHUMORAL SUBSTANCES IN THE CENTRAL NERVOUS SYSTEM
- 1. Introduction
- 2. The physiological background
- 3. Humoral factors in the brain
- 4. Classification and properties of the psychotropic drugs
- 5. Psychotropic drugs and neurohumoral processes
- 6. Conclusions
- CHAPTER 6. THE NITROFURANS
- 1. Introduction to historical development
- 2. Chemical and physical properties of nitrofuran compounds
- 3. Synthesis of nitrofurans
- 4. Toxicology, pharmacology and tolerancv
- 5. Assays of nitrofurans
- 6. Metabolism of nitrofurans
- 7. Antibacterial properties in vitro
- 8. Antibacterial properties in vivo
- Addendum
- Index
