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Trace Elements in Human Health and Disease, Volume II: Essential and Toxic Elements is a collection of papers presented at an international symposium on trace elements held in Detroit, Michigan on July 10-12, 1974. The symposium provided a forum for discussing the role of essential and toxic elements such as magnesium and chromium in human health and disease. Comprised of 21 chapters, this volume begins with an overview of magnesium deficiency and magnesium toxicity in humans, followed by an analysis of magnesium deficiency and its relation to calcium, parathyroid hormone, and bone metabolism. The reader is then introduced to the biochemistry and physiology of magnesium, along with chromium metabolism and its biochemical effects on humans. Subsequent chapters deal with the metabolism and biochemistry of selenium and sulfur; the health and disease implications of selenium and glutathione peroxidase; effect of pre-eruptive or post-eruptive fluoride administration on caries susceptibility in the rat; and perinatal effects of trace element deficiencies. The book also considers the basis of recommended dietary allowances for trace elements before concluding with a description of quantitative measures of the toxicity of mercury in humans. This book will be useful to physicians, researchers, nutritionists, and toxicologists.
Language
Place of publication
Publishing group
Elsevier Science & Techn.
ISBN-13
978-1-4832-6207-9 (9781483262079)
Schweitzer Classification
List of ContributorsPrefaceContents of Volume I26 Magnesium Deficiency and Magnesium Toxicity in Man I. Introduction II. Magnesium Deficiency III. Magnesium Intoxication IV. Summary References27 Magnesium Deficiency and Calcium and Parathyroid Hormone Interrelations I. Introduction II. Experimental Symptomatic Magnesium Deficiency in Man III. Observations in Other Species IV. Interrelationships among Magnesium, Calcium, Parathyroid Hormone, and Bone Metabolism V. In Vitro Studies Relating Magnesium to Parathyroid Gland Activity VI. Effect of Parathyroid Extract in Vivo VII. Conclusion References28 Biochemistry and Physiology of Magnesium I. Introduction II. Biochemistry of Magnesium III. Physiology of Magnesium IV. Research Needs References29 Chromium Metabolism in Man and Biochemical Effects I. Introduction II. Role and Structure of Glucose Tolerance Factor (GTF) III. Evidence for Chromium Deficiency in Animals and Man IV. Chromium Content of the Diet V. Absorption, Transport, and Excretion of Chromium VI. Biological Effects of GTF Supplementation of the Diet VII. Unsolved Problems and Research Needs VIII. Summary References30 Selenium in Man I. Introduction II. Dietary Intake III. Metabolism IV. Tissue Levels V. Deficiency VI. Toxicity VII. Medical Applications VIII. Assessment of Selenium Status IX. Research Needs Addendum References31 Selected Aspects of the Comparative Metabolism and Biochemistry of Selenium and Sulfur I. Introduction II. Comparative Metabolism of Selenium and Sulfur III. Comparative Biochemistry of Selenium and Sulfur IV. Research Needs References32 Selenium and Glutathione Peroxidase in Health and Disease-A Review I. Introduction II. Properties of Glutathione Peroxidase III. Assay of Glutathione Peroxidase IV. Distribution of Glutathione Peroxidase V. Cellular Functions of Glutathione Peroxidase VI. Glutathione Peroxidase in Human Diseases VII. Research Needs References33 Metabolism and Function of Manganese I. Introduction II. Metabolism of Manganese III. Biochemical and Physiological Changes Associated with Manganese Deficiency IV. Biochemical Function of Manganese V. Summary and Conclusions References34 Fluoride Metabolism-Effect of Preeruptive or Posteruptive Fluoride Administration on Rat Caries Susceptibility I. Introduction II. Materials and Methods III. Results IV. Discussion V. Conclusion VI. Summary References35 Methodology of Trace Element Research I. Introduction II. Trace Element Diversity and Characteristics III. The Essential Elements IV. Naturally Occurring "Area Problems with Trace Elements V. Methodological Problems with Purified and Special Diets References36 Mineral Interrelationships I. Introduction II. Interaction of Trace Elements III. Research Needs References37 Perinatal Effects of Trace Element Deficiencies I. Introduction II. Copper III. Manganese IV. Zinc V. Magnesium VI. Conclusion References38 Effects of Oral Contraceptive Agents on Trace Element Metabolism-A Review I. Introduction II. Oral Contraceptives and Trace Element Metabolism III. Future Research Needs References39 Human Intake of Trace Elements I. Introduction II. Diet in the Trace Element Deficiency of Egyptians III. Research Needs References40 Basis of Recommended Dietary Allowances for Trace Elements I. Introduction II. What Is a Recommended Dietary Allowance? III. Considerations in Setting RDA IV. RDA for Trace Elements V. Need for More Knowledge on Which to Base RDA References41 Newer Trace Elements and Possible Application in Man I. Introduction II. Review and Discussion III.