
Cardiovascular MR Manual
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Content
- Intro
- Contents
- Contributors
- Part I: How Does CMR Work?
- 1: What's Inside the Magnet and Why?
- The Main Magnet
- The Gradient Coil Assembly
- The Integral Radiofrequency (RF) Body Transmitter Coil
- The Receiver Coil
- Further Reading
- 2: The MRI Environment
- The Examination Room and RF Shielding
- The Magnetic Fringe Field Hazard and the Controlled Area
- Active and Passive Magnetic Shielding
- References
- 3: Protons and Spins: The Origin of the MR Signal
- MR Images: What Are We Looking at?
- Proton Spin and Net Magnetisation
- What Determines the Size of the Net Magnetisation?
- Further Reading
- 4: Generating a Signal: RF Pulses and Echoes
- How Do We Generate a Signal?
- What Does the RF Pulse Do to the Magnetisation?
- Longitudinal and Transverse Components of Magnetisation
- Flip Angle and Common RF Pulses
- Low Flip Angle RF Excitation Pulse
- 90° RF Excitation Pulse
- 180° RF Pulse (Refocusing Pulse)
- 180° RF Pulse (Inversion Pulse)
- What Does the MR Signal Look Like?
- Further Reading
- 5: Relaxation Times, Gradient Echoes and Spin Echoes
- Relaxation: What Happens After the RF Excitation Pulse?
- What is T1 Relaxation?
- Transverse Relaxation and MR Signal Decay
- What is T2 Relaxation?
- What is T2* Relaxation?
- MR Echoes
- Gradient Echoes
- Spin Echoes
- Further Reading
- 6: Making an Image: Locating and Encoding Signals in Space
- Selecting an Image Slice
- Encoding the MR Signal within the Slice
- Phase Encoding
- Frequency Encoding
- How is the Frequency-Encoded Signal Decoded?
- How Do We Make Sure That the Gradients We Apply for Imaging don't Destroy the Signal?
- Why isn't a Single Phase and Frequency Encoded Signal Enough to Reconstruct an Image?
- Field of View in the Phase Encoding Direction
- Phase Encoding, Image Matrix and Acquisition Time
- Further Reading
- 7: Image Space and k-Space
- Further Reading
- 8: Imaging Parameters and Image Attributes
- Spatial Resolution and Image Acquisition Time
- Noise and Signal-to-Noise Ratio
- Factors that Determine Image Quality
- Intrinsic Signal Amplitude
- Signal Averaging
- SNR and Receiver Bandwidth
- Imaging Parameters: Practical Examples
- 2D and 3D Imaging
- Further Reading
- 9: Improving SNR with Surface Coils and Array Coils
- Further Reading
- 10: Pulse Sequences and Image Contrast
- Dependence of the MR Signal on TR and TE
- Image Contrast and Weighting
- Long TR and Short TE (Fig. 10.2)
- Short TR, Short TE (Fig. 10.3)
- Long TR, Long TE (Fig. 10.4)
- Short TR, Long TE (Fig. 10.5)
- Further Reading
- 11: Gradient Echo Versus Spin Echo
- Further Reading
- 12: Black Blood Versus Bright Blood Imaging
- Black Blood (Spin Echo Pulse Sequence)
- Black Blood: Double Inversion Preparation Pulses
- Bright Blood (Gradient Echo Pulse Sequence)
- Further Reading
- 13: Dealing with Cardiac Motion: How Do We Image the Beating Heart?
- Still Imaging
- Cine Imaging
- Triggering Versus Gating for Cine Imaging
- Prospective Versus Retrospective ECG Gating
- Spoiled Gradient Echo Versus bSSFP
- Spoiled Gradient Echo
- Balanced Steady State Free Precession (bSSFP)
- Further Reading
- 14: Dealing with Respiratory Motion
- Respiratory Compensation (Respiratory Gating)
- Respiratory Gating Using Navigator Echoes
- Further Reading
- 15: Fast Imaging: How Do We Speed Up the Image Acquisition?
- Turbo (or Fast) Spin Echo
- Turbo (or Fast) Gradient Echo
- Fast Spoiled Gradient Echo
- Steady State Free Precession (SSFP)
- Echo Planar Imaging (EPI)
- Reducing the Total Number of Phase Encoding Steps Acquired for Each Image
- Parallel Imaging
- Further Reading
- 16: Special Pulse Sequences for Cardiac Imaging
- Selective Tissue Saturation
- Frequency Selective Fat Suppression
- Pros and Cons of Frequency-Selective Fat Suppression (cf. STIR)
- STIR and Turbo STIR
- Pros and Cons of STIR (cf. Frequency-Selective Fat Suppression)
- Black Blood FSE/TSE
- Black Blood TurboSTIR (Triple Inversion Recovery)
- Inversion Recovery Fast/Turbo Gradient Echo
- Navigator-Gated 3D Fast/Turbo Gradient Echo (Coronary Artery Imaging)
- Key Features of a Navigator-Gated 3D Coronary Artery Imaging Sequence
- Cine Gradient Echo
- Velocity Encoded Cine Gradient Echo (Velocity Mapping)
- Myocardial Tagging (Binomial Preparation Pulses)
- Saturation Recovery, Single-Shot Fast Gradient Echo for Dynamic, Contrast-Enhanced Myocardial Perfusion Imaging
- Further Reading
- 17: Common Artefacts
- Image Aliasing
- Aliasing Artefacts with Parallel Imaging
- Ghosting Artefacts from Motion (Respiratory)
- Ghosting Artefacts from Motion (Pulsatile Flow)
- Flow Related Signal Loss & Flow Jets
- Chemical Shift Artefact
- Magnetic Susceptibility Artefacts
- Metallic Artefact
- Radiofrequency Interference Artefacts
- Reference
- Further Reading
- 18: Influence of Field Strength on CMR
- Potential Benefits of Increasing Field Strength from 1.5 to 3.0 T
- Drawbacks and Technical Challenges of Imaging at 3.0 T
- Increased ECG Artefact
- Increased Magnetic Susceptibility Artefacts
- Increased Specific Absorption Rate (SAR)
- Increased Inhomogeneity of the RF (B1) Field
- Changes to Relaxation Times
- Safety of Implanted Devices at 3.0 T
- Clinical CMR Techniques at 3.0 T
- Black-Blood Fast/Turbo Spin Echo
- Functional Cine Imaging
- Velocity-Encoded Cine Imaging
- Myocardial Tagging
- Late Gadolinium Enhancement (LGE) Imaging
- Myocardial Perfusion Imaging
- Magnetic Resonance Angiography (MRA)
- 3D Navigator-Gated Coronary MRA
- References
- Further Reading
- Part II: How CMR Is Performed
- 19: The Basics of a CMR Study
- The Referral
- Indications for CMR
- Contraindications/Safety
- Screening
- Contraindications to CMR Scanning
- Medical Devices
- Heating Effects
- Contrast Agents and Nephrogenic Systemic Fibrosis
- Performing Stress Examinations in CMR
- Other Safety Issues
- Setting up a CMR Study
- Equipment
- ECG Signals
- Patient Preparation
- Commencing the Scan
- References
- 20: Components of CMR Protocols
- Introduction
- Localising Images and Simple Planning
- Interactive Planning
- Anatomical & Morphological Imaging
- T1-weighted (Black Blood) Imaging
- T2-weighted (Black Blood) Imaging
- T2* Relaxometry
- Cine Imaging
- Real-Time Cine Imaging
- Quantitation
- Myocardial Tagging
- Phase Contrast Velocity Encoding
- Contrast Enhanced MR Angiography (Excluding Coronary Arteries)
- Myocardial Perfusion CMR
- Spoiled Gradient Echo
- Balanced Steady State Free Precession (bSSFP)
- Echo Planar Imaging (EPI)
- Reproducible Planning of Three Short Axis Slices
- 'Dark Rim Artefact'
- Interpretation of CMR Myocardial Perfusion Images
- Visual Assessment
- Semi-Quantitative Assessment
- Quantitative Assessment
- Early and Late Gadolinium Enhancement (LGE)
- Protocol for Early & Late Gadolinium Enhancement (LGE) Imaging
- T1, T2 and T2* Mapping Techniques
- T1 Mapping
- T2 and T2* Mapping
- Coronary Artery Imaging
- Whole Heart Technique
- Targeted Technique
- 21: Anatomy by CMR
- Cross-Sectional Anatomy
- Customised Views
- Comparison with Other Imaging Modalities
- 22: The CMR Report
- A Structured Approach to Reporting a CMR Study
- The Report
- Reference
- Part III: Clinical Indications for CMR Imaging
- 23: Aortic Disease
- Introduction
- CMR in the Assessment of Aortic Atherosclerosis and Dissection
- Acute Intramural Haematoma
- Penetrating Atherosclerotic Ulcer
- Aortic Dissection
- Aortic Aneurysm
- Aortic Coarctation
- Aortic Vasculitis
- Chronic Atherosclerotic Disease
- Summary
- 24: Cardiomyopathies
- General Overview
- Dilated Cardiomyopathy (DCM)
- Introduction
- CMR Versus Other Imaging Modalities in DCM
- Hypertrophic Cardiomyopathy (HCM)
- Introduction
- CMR Versus Other Imaging Modalities
- Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
- Introduction
- CMR Versus Other Imaging Modalities
- Left Ventricular Non-compaction Cardiomyopathy (LVNC)
- Introduction
- CMR Versus Other Imaging Modalities
- Inflammatory Diseases: Myocarditis
- Introduction
- CMR Versus Other Imaging Modalities
- Inflammatory Diseases: Sarcoidosis
- Introduction
- Inflammatory Diseases: Vasculitis (Churg-Strauss Syndrome)
- Introduction
- Infiltrative/Storage Diseases: Amyloidosis
- Introduction
- Infiltrative/Storage Diseases: Siderotic Cardiomyopathy
- Introduction
- CMR Versus Other Imaging Modalities
- Tako-Tsubo Cardiomyopathy
- Introduction
- CMR Versus Other Imaging Modalities
- References
- 25: Cardiac Transplantation
- Introduction
- CMR Versus Other Imaging Modalities
- Heart Transplant Anatomy
- The Early Post Operative Period (Up to 1 Year)
- Typical CMR Appearances
- Complications
- Primary Graft Dysfunction/Failure
- Myocardial Infarction
- Acute Rejection
- The Chronic Phase Post-transplant (Beyond 1 Year)
- Typical CMR Appearances
- Complications
- Cardiac Allograft Vasculopathy (CAV)
- Acute Rejection
- Chronic Graft Failure
- Vascular
- Extracardiac Findings
- References
- 26: Pericardial Disease
- Pericardial Effusion
- Introduction
- CMR Versus Other Imaging Modalities
- Findings on CMR
- Black Blood Images (Spin Echo Sequence)
- CINE Imaging (b-SSFP)
- Targeted Sequences
- Constrictive Pericarditis
- Introduction
- The Role of CMR in Constrictive Pericarditis
- Findings on CMR
- Pericardial Thickening
- Indirect Signs of Constrictive Physiology
- Pericardial Tumours
- Introduction
- CMR Versus Other Imaging Modalities
- Findings on CMR
- CINE Imaging (b-SSFP)
- Myocardial Tagging
- Black Blood Images (TSE)
- First-Pass Perfusion Imaging
- Post Contrast T1 TSE and Delayed Enhanced Images
- Congenital Abnormalities of the Pericardium
- Pericardial Cysts and Pericardial Defects
- Introduction
- The Role of CMR in Congenital Pericardial Abnormalities
- Findings on CMR
- 27: Cardiac Masses
- Introduction
- Benign Cardiac Tumours
- Myxoma
- Lipoma
- Papillary Fibroelastoma
- Fibroma
- Rhabdomyoma
- Haemangioma
- Malignant Cardiac Tumours
- Sarcomas
- Lymphoma
- Metastatic Tumours
- Others Masses & Tumours
- Thrombus
- Cysts
- Pseudo-Tumours
- Additional Reading
- 28: Valvular Heart Disease
- Introduction
- CMR Versus Other Imaging Modalities
- Congenital
- Regurgitation
- Stenosis
- Prosthetic Valves
- Transcatheter Aortic Valve Implantation
- Patient Selection
- Aortic Valve Assessment
- Left Ventricle
- Coronary Artery Disease
- Myocardial Fibrosis
- Anatomical Suitability
- Aortic Root and LVOT
- Ascending Aorta and Peripheral Vasculature
- Vegetations
- Paravalvular Abscesses
- References
- 29: Ischemic Heart Disease
- Introduction
- Stress Myocardial Perfusion Imaging for the Detection of Myocardial Ischaemia
- Myocardial Perfusion CMR Versus Other Imaging Modalities
- Prognostic Performance
- How to Perform a CMR Myocardial Perfusion Study
- Safety Considerations
- Analysis of CMR Perfusion Images
- CMR Stress Wall Motion Imaging for the Detection of IHD
- Introduction
- CMR Versus Other Imaging Modalities
- Diagnostic Performance
- Prognostic Performance
- Method
- Safety Considerations
- Analysis
- Which Pharmacological Stress Agent Should I Choose?
- CMR for Assessment of Viability
- Introduction
- CMR Versus Other Imaging Modalities
- CMR Methods for Viability Assessment
- Cine Imaging
- Contractile Reserve
- Late Gadolinium Enhancement
- CMR in Acute Coronary Syndromes
- Introduction
- CMR Versus Other Imaging Modalities
- Methods
- Cine and LGE-CMR
- Oedema Imaging for Area at Risk Assessment
- Myocardial Salvage
- Microvascular Obstruction
- Myocardial Haemorrhage
- Complications of Acute MI
- Raised Cardiac Enzymes and Normal Coronary Arteries
- Potential Future Developments
- Hardware Development
- Software Development
- New Methods
- Non-invasive Arterial Wall Imaging
- Myocardial Perfusion Imaging Without Contrast?
- Targeted (Molecular) Contrast Agents
- References
- 30: Basic Adult Congenital Heart Disease (ACHD)
- Introduction
- Sequential Segmental Analysis in ACHD
- Coarctation of the Aorta
- Tetralogy of Fallot
- Transposition of the Great Arteries
- Coronary Anomalies
- Partial Anomalous Pulmonary Venous Return (PAPVR)
- Reporting Guidelines
- Cardiovascular
- Pulmonary
- Musculoskeletal
- Other Findings
- Opinion
- Recommendations for Further Imaging
- Summary
- 31: CMR and Implantable Devices
- Introduction
- MRI Safety Terminology
- Pacemaker and or Lead Displacement/Force and Torque
- Tissue Heating
- Device Malfunction
- Reed Switches
- Electrical Reset
- Inappropriate Pacing and Inhibition of Therapies
- Capacitor and Transformer
- Image Quality
- MR Conditional Devices
- Scanning of IPG Patients
- Who Should Receive an MR-Conditional Device?
- Decision Making/Flow Charts/Check Lists
- Summary
- Future Perspective
- References
- 32: Pulmonary Vein Assessment
- Introduction
- CMR Versus Other Imaging Modalities
- CMR Protocol and Findings
- CMR Analysis
- 33: Interventional Cardiovascular Magnetic Resonance Imaging
- Introduction
- Interventional MRI Systems
- XMR Facility Design
- MR Visualization Strategies
- Performing XMR Procedures
- X-Ray Imaging as a Backup During MRI Cardiac Catheterization
- Performing X-Ray Fused MR-Guided Interventions
- Physiological Information
- Early Experiences
- Future Perspectives
- References
- 34: Incidental Extra-Cardiac Findings in CMR
- Introduction
- Incidence and Classification
- Detection of IEF
- Reporting
- Further Reading
- Index
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