Lymphokines

ContributorsPrefaceTransfer Factor I. Introduction II. Progress toward Purification and Characterization of Transfer Factor III. In Vitro Assays for Transfer Factor IV. Recent Progress with Animal Models V. On the Mechanism of Action VI. Clinical Applications of Transfer Factor VII. Summary and Conclusions ReferencesIgE-Binding Factors from Rat T Lymphocytes I. Introduction II. Role of IgE-Binding Factors in the Regulation of the IgE Response II. Induction of IgE-Binding Factors with Biologic Activity IV Conclusion ReferencesA Polyclonal B-Cell Activating Lymphokine and Its Natural Inhibitor: Possible Role in Antibody Formation and Autoimmune Diseases I. Introduction II. Hypothetical Models for Antibody Formation with a Role for a Polyclonal B-Cell Activator (PBA) III. A Hypothetical Model for the Pathogenesis of Autoimmune Diseases without a Role for Antigens IV. Methods for Detecting Polyclonal B-Cell Activators V. Induction of a PBA in Cultures of Rabbit Lymphoid Cells VI. The Molecular Nature of the PBA Produced in Lymphoid Cell Cultures VII. The Cells Involved in the Production of PBA in Rabbit Lymphoid Cell Cultures VIII. The Induction of PBA Associated with a-Macroglobulin (aM) in Vivo IX. PBA in the Serum of Patients with Rheumatoid Arthritis and Other Autoimmune Diseases X. The Molecular Nature of PBA Obtained from Patient Serum XI. Low-Molecular-Weight PBA Inhibitor (LOMPIN) in the Serum of Patients with Rheumatoid Arthritis XII. Discussion on the Mechanisms of Antibody Formation, Autoimmunity, and the Role of PBA XIII. Summary and Conclusions ReferencesLymphokines and Antigen-Specific T-Cell Products in Contact Sensitivity I. Introduction II. Ts-aff: The T Suppressor Cell Which Acts at the Afferent Stage of the Contact Sensitivity Reaction III. T Suppressor Circuit Involving Ts-eff, TsF, and T Acceptor Cell and Nonspecific Inhibitor(s) IV. T Suppressor Factor (TsF) V. The T Acceptor Cell VI. Nonspecific Inhibitor Released by the T Acceptor Cell VII. The Macrophage as an Acceptor Cell VIII. Function of the T Suppressor Circuits IX. Summary ReferencesStudies on the Activation of Cytotoxicity and/or Suppressor Activity in Murine Macrophages by Lymphokines, Lipopolysaccharide, and Polyinosinic-Polycytidylic Acid I. Introduction II. Induction of Tumoricidal Macrophages in Vitro III. Induction of Suppressor MF in Vitro IV. Summary and Concluding Remarks ReferencesThe Role of Clotting Processes in the Action of Lymphokines on Macrophages I. Introduction II. Fibrin Deposition in Delayed-type Hypersensitivity Reactions III. Fibrin Deposition on Macrophage Populations IV. Initiation of Coagulation by Lymphokines V. Macrophage Procoagulant Activity (MPCA) VI. MPCA as a Correlate of Cell-Mediated Immunity VII. Macrophage Tumor Cell Lines as Indicator Cells of MPCA VIII. Identification of the Procoagulant Activity IX. Relationship of MPCA and Migration Inhibition X. Characterization of the Lymphokine Inducing MPCA XI. Fibronectin: Receptor for the Fibrin Network XII. Blood Coagulation and Chemotaxis XIII. Conclusion ReferencesA Chemically Defined Monokine: Macrophage-Derived Platelet-Activating Factor (PAF-Acether) I. Introduction II. Structure, Assay, and Characterization of PAF-Acether III. Sources of PAF-Acether Other Than Macrophages IV. Release of PAF-Acether from Peritoneal Macrophages V. Release of PAF-Acether from Alveolar Macrophages and Monocytes VI. PAF-Acether Metabolism VII. Effects of PAF-Acether on Cells Involved in Inflammation VIII. Pathobiological Effects of PAF-Acether IX. Concluding Remarks ReferencesGenetic Control of the Response to Interferon in Man and Mouse I. Introduction II. The Interferon Receptor Locus (IFRC) III.