Mosaic of Autoimmunity
The Novel Factors of Autoimmune Diseases
Published on 8. February 2019
728 pages
978-0-12-814308-7 (ISBN)
Description
The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.
An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
- Highlights the concept of the mosaic of autoimmune manifestations
- Includes new visions on unsuspected molecules
- Provides updated knowledge to physicians helping patients with autoimmune diseases
- Presents thorough, up-to-date information on specific diseases, along with clinical applications
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02/2019
Academic Press
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Content
Introduction1. The history of the mosaic of autoimmunity2. The novel aspects on the mosaic of autoimmunity
Cellular and molecular mechanisms3. B cells4. B-reg 5. T cells6. Th17 cells7. NK cells8. Dendritic cells9. Complement10. Autoantibodies11. Anti-DSF7012. Genetic13. Epigenetic14. Post-translational modifications15. Cytokines and chemokines16. Autophagy17. Diagnostic: laboratory 18. Diagnostic: imaging
The classical factors associated with autoimmunity19. Hormones20. Microbiota21. Infections: Viruses and bacteria
The novel environmental factors associated with autoimmunity22. Geo-epidemiology23. Seasonality24. UV25. Vitamin D26. Vitamin D pregnancy and autoimmunity27. Smell28. Breast feeding29. Vaccines30. Silicone31. Diet: spicy food and fatty acids32. Diet: gluten33. Psychological stress34. Coffee35. Obesity36. Physical activity37. Smoke38. Cannabis39. Bisphenol40. Prolactin
Peculiar aspects41. Cancer42. Paraneoplastic syndromes
Classical autoimmune diseases43. SLE44. APS45. CAPS46. RA and inflammatory arthritides47. PsA and Spondyloarthropathies48. MS, MG and other neurological disorders49. Systemic slcerosis50. Sjogren51. ASIA syndrome52. Reproductive failure53. Accelerated atherosclerosis54. New autoimmune diseases
Treatment of autoimmune diseases55. Neuroimmunology56. Vasculitis57. Personalized Medicine58. Biologics and Biosimilars59. Small molecules60. Helminthes61. Novel therapies and IVIg62. Autoimmune and allergic disease63. EBV Molecular Diagnosis64. Statin and myositis65. Autoimmunity and primary immunodeficiency
