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Protides of the Biological Fluids: Metal Binding Proteins, Tumor Markers, Monoclonal Antibodies covers the proceedings of the 31st Colloquium by the same title, held in Brussels, Belgium in 1983. This work is composed of three sections encompassing 245 chapters. The first section describes first the structure, physiological function, and physiopathology of metal binding proteins. This section also considers the metal binding mechanism and a series of iron binding and copper binding proteins, as well as hemopexin proteins. The second section is concerned with the physiopathology, screening, monitoring, tumor localization, and biomarkers of tumor. This section also explores the field of immunohistochemistry of biomarkers for tumor monitoring. The third section discusses drug targeting, immunohistochemistry, the identification of lymphocytes and other antigens. Considerable chapters are devoted to clinical assays of monoclonal antibodies. This book will prove useful to oncologists, protein scientists, clinicians, and researchers.
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978-1-4832-7965-7 (9781483279657)
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¿PrefaceAcknowledgementsThe Twelfth Arne Tiselius Memorial Lecture Association Between HLA and Diseases: Biological and Clinical RelevanceSection A. Metal Binding Proteins A.1. Metal Binding Mechanism Metal Binding to Serum Proteins Interactions of Pregnancy Associated Plasma Protein-A (PAPP-A) and a2 Macroglobulin (a2M) on Metal Chelate Affinity Chromatography Interaction of the Histidine-Rich Glycoprotein of Serum with Metals and Plasmin Binding of Calcium to Intrinsic Factor (IF) and to the Alpha Subunit of its Receptor Specificity of Metal Binding to Serum Thymic Factor (FTS) Hydrogen Peroxide Involvement in the Mechanism of Action of Cytochromec Oxidase Zinc and Iron Absorption in Endotoxin Pretreated Rats A Sensitive Micromethod for the Study of Iron Uptake by Mitogen-Stimulated Human Blood Mononuclear Leukocytes Iron-Deficiency Anaemia Modifies Brain Function Via Dopamine Receptor Subsensitivity A.2. Iron Binding Proteins A.2.1. Transferrin The Molecular Basis of Ferrokinetics: The Explanation of the Fletcher-Huehns Phenomenon The Discovery of Transferrin in Invertebrates Crossed Immunoaffinity Electrophoresis of Human Transferrin in Normal and Cirrhotic Sera Heterogeneity of Human Transferrins No Functional Difference of the Two Iron-Binding Sites of Human Transferrin in Vitro and in Vivo Transferrin Protein and Iron Uptake by Cultured Mammalian Cells Interaction Between Transferrin and Tumor Cell Receptor Redox Reactions in Hepatocyte Iron Uptake Transferrin as a Donor of Iron to Rat Liver Mitochondria - Effect of Pyrophosphate The Kinetics o f Duodenal Mucosa Iron Uptake in the Developing Guinea Pig Transferrin Protein and Iron Uptake by Liver Parenchymal Cells Intestinal Transferrin Uptake of 59Fe-125I- Transferrin by K-562 Cells Isoelectric Focusing of Inherited Transferrin Variants with Immobilized pH Gradients An ELISA Technique for Measurement of Transferrin Glyco-Variants in Body Fluids Using Lectins Bound to a Solid Phase Does Iron-Transferrin Saturation Influence the Immunoturbidimetric Determination of Human Serum Transferrin? A.2.2. Lactotransferrin The Present State of the Human Lactotransferrin Sequence Lactoferrin Stimulates the Production of "Leukocyte Migration Inhibitory Factor" (LIF) by Mononuclear Leukocytes Lactoferrin Uptake by the Reticuloendothelial System of the Mouse Liver Comparison of the Interaction of Lactoferrin with Hepatocytes, Lymphocytes and Monocytes Comparative Study of the Iron Binding Sites of Transferrins: Demonstration of the Non-Identity of the Two Sites of Human Lactotransferrin Lactoferrin Binding to Peripheral Human Leukocytes Lactoferrin and Transferrin Levels in the Seminal Plasma of Infertile Men A.2.3. Ovotransferrin Binding Site Studies of Ovotransferrin by UV and NMR Spectroscopies A.2.4. Ferritin Intracellular Iron Metabolism Revisited The Metabolism of Plasma Ferritin Amino Acid Sequence Studies on Human Apoferritins Ferritin Structure and Function Ferritin and Metal Toxicity Analysis of Various Isoferritins with Monoclonal Antibodies Possible Changes in the Isoferritin Profile During Infancy and Childhood Increased Urinary Excretion of Ferritin in Subjects with Moderate Proteinuria The Isoferritin Composition of Rat Liver During Bleeding Induced Catabolism of Liver Ferritin Influence of Heat-Treatment on Rabbit Liver-Ferritin Iron Mobilization From Cultured Rat Macrophages Loaded with 59Fe Labelled Erythroblasts Serum Ferritin Level in Hemodialysis Patients A.2.5.