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Protides of the Biological Fluids documents the proceedings of the XVIITH Colloquium held in Bruges in 1969. This book is divided into three sections. Section A discusses the genetics of the antibody response, focusing on the evolutionary aspects and genetics of differentiation centered on the problems of immunoglobulin structure and deficiencies. The molecular variation occurring in the amino acid sequence of various proteins, its ways of detection and its physiological significance, is presented in Section B. Some of the proteins considered include hemoglobin, fibrinogen, complement, and lipoproteins. Section C is devoted to the developments in theoretical and instrumental aspects of electrofocusing, considering the ampholyte structure and function and techniques, such as gel electrofocusing and preparative column electrofocusing. This compilation is beneficial to researchers and specialists concerned with protides of the biological fluids.
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978-1-4831-8654-2 (9781483186542)
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PrefaceAcknowledgmentsAcademic Lecture Molecular Variation in ProteinsSection A: Genetics of the Antibody Response Introduction to the Symposium A1. Evolutionary Aspects Evolution of the Immune Response Gene Duplication as an Evolutionary Force The Variability of Human Immunoglobulins The Genetic Control of Antibody Variability Specific Blocking of in vitro Antibody Response by Affinity Labeling Reagents The Inverse Wobble Theory Some Facts about the Evolution of Immunoglobulins A2. Genetics of Differentiation Thymus Deficiency in Mice Thymus and Possible Pathogenic Mechanisms of Immunologie Deficiency in Man The Genetics of IgA Deficiency Genetic Studies on Isolated Deficiency of ¿A Globulin The Deficiency of Certain Sub-Groups of Human ¿G as Demonstrated by the Study of Allotypes A3. Genetics of Productive Processes -Allotypy -Idiotypy -Immunological Responsiveness to Haptens A4. Genetics of Regulatory Mechanisms Allotypy as a Probe The Expression of Immunoglobulin AUotypic Specificities by Rabbit Lymphocytes The Quantitative Expression, Genetics and Chemistry of Allotypes, Types and Subtypes of Rabbit Light Polypeptide Chains Antigenic Modulation Subclass and Allotype Differences in Human yG Immunoglobulins Reflected by the Amino Acid Sequence of Fc Glycopeptides The Genes of the Gm System, Are they Structural Genes?Section B: Molecular Variation B1. Haemoglobin Multiple a and ß Chain Structural Genes as a Basis for Hemoglobin Heterogeneity of the Adult Goat Investigations of Molecular Variation in Human Fetal Hemoglobin in the Infant and in Certain Hematological Conditions in the Adult Molecular Changes in Haemoglobins during Development and Their Functional Significance Duplication of the Haemoglobin a-chain Locus in Macaca irus On the Heterogeneity of Equine Myoglobin Partial Structure of Beef Myoglobin Unstable Haemoglobin with a Modified Affinity for Oxygen in a French Patient B2. Fibrinogen Molecular Variation of Human Fibrinogen Fibrinogen "Zurich". Separation of a Pathological from a Normal Fibrin Fraction Electrophoresis and Chromatography of Native and of Sulphitolysed Fibrinogen B3. Complement Genetic Polymorphism of Human C3 C6-Deficiency in Rabbits Guinea Pig C'la-Inactivator: Purification and Characterization Characterization of the Purified Fourth Component of Guinea Pig Complement A Tool for the Detection of C'6 Deficiencies B4. Lipoproteins Location of Antigenic Specificity in Human Serum Lipoproteins The Explanation of the Variability in Streptolysin O Binding Capacity of Human ß-Lipoprotein New Aspects of Human Low Density Lipoprotein Polymorphism Immunological and Biochemical Characterization of the LDL Proteins B5. Other Proteins Molecular Variations in Erythrocyte Catalase Molecular Variation in an Intra- and Extracellular R-type Vitamin B12-Binding Protein Heterogeneity of the Haptoglobin 1-1 Molecule by Electrophoresis of Human Serum in Starch Gels at pH 4-9 Isolation of a Lysine-Rich, Serine-Rich Histone from Calf ThymusSection C: Electrofocusing C1.