Protides of the Biological Fluids
Proceedings of the Twenty-Seventh Colloquium, 1979
Published on 20. May 2014
922 pages
978-1-4831-5835-8 (ISBN)
Description
Protides of the Biological Fluids reviews trends in research concerning protides of the biological fluids, with emphasis on tumor-associated antigens (TAAs), lectins, and separation methods such as electrophoresis and isoelectric focusing. Examples of TAAs discussed in this book are carcinoembryonic antigens, mesenchyme-associated antigens, and oncofetal pancreatic antigens. The mode of action of lectins as well as lectin-binding sites are also considered. This book is comprised of 195 chapters and begins with an overview of the strategy and monitoring of protein fractionation, followed by a discussion on the self-nonself concept of cancer and ""autoimmune"" diseases; presence of trophoblast antigens on the membranes of some human tumor and transformed cells; and non-specific cross-reacting antigens in human blood monocytes. Subsequent chapters explore the metabolism of carcinoembryonic antigen and alpha-fetoprotein during delivery; amino acid sequence identity of tissue polypeptide antigen fragments from different sources; isoferritins, glycoproteins, and viral antigens; and crossed immunoelectrophoresis of yeast plasma membrane lectin receptors. The final section is devoted to separation techniques such as isotachophoresis, chromatography, electrophoresis, and isoelectric focusing. This monograph will be of value to biologists and researchers interested in protides of the biological fluids.
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02/1980
Pergamon
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Content
PrefaceAcknowledgmentsThe Eighth Arne Tiselius Memorial Lecture Strategy and Monitoring of Protein FractionationSection A. Tumor Associated Antigens (TAA) A.1. Introduction Self-Nonself Concept of Cancer and 'Autoimmune' Diseases A.2. Basic Data on TAA in Man A.2.1. TA: Trophoblast Antigens A.2.2. NCA: Non specific Cross Reacting Antigens A.2.3. CEA: Carcino Embryonic Antigens A.2.4. MAA: Mesenchyme Associated Antigens A.2.5. AFP: Alfa Fetoproteins A.2.6. OPA: Oncofetal Pancreatic Antigens A.2.7. TPA: Tissue Polypeptide Antigens A.2.8. Isoferritins A.2.9. Glycoproteins A.2.10. Viral Antigens A.2.11. LAA: Leukemia Associated Antigens A.3. Basic Data on TAA in Experimental Tumors A.3.1. Hepatoma A.3.2. Teratoma A.3.3. Neuroblastoma A.3.4. Mastocytoma A.3.5. Leukemia A.4. Tumor Markers as a Clinical Tool A.4.1. Markers in Cancer Tissue A.4.2. Markers in Plasma and UrineSection B. Lectins B.1. Characterization of Lee tins Glycosyl Derivatives of Separon and their Use in Isolation and Immobilization of Lectins Resedine: an Albumin-Inhibitable Lectin from Lawsonia inermis Var. "Reseda" Some Properties of Rice Germ Agglutinin (RGA) Characterization and Specificity of an Anti-N Lectin Isolated from Vioia graminea Seeds Structure and Properties of the Toxic Lectin Modeccin Pea Seed Lectin (PEA) A Lectin from E. coli Specific for the Amino Acid L-Histidine The Axinella Polypoides Lectins and their Occurrence in the Sponge Tissue A Complement Activating Lectin from the Albumin Gland of Helix aspersa Lymphocyte Agglutination and Hemagglutination Androctonus and Limulus Agglutinins Lectins from the Horseshoe Crab, Limulus polyphemus3 Reactive with Bacterial Lipopolysaccharide B.2. Mode of Action of Lectins Control of Cell Aggregation by Membrane Macromolecules The Interaction between Viruses and Lectins. The Contribution of Hydrophobic Bonding A Study of Lectin Binding to Mammalian Lymphoid Cells Using Fluorochromasia and Fluorescence Polarization Techniques Structure-Function Relationship among Leguminous Plant Lectins Redistribution of Lentil Lectin Receptors on Rabbit Polymorphonuclear Membranes Mechanism of the Interaction of Ricinus communis Lectins with Saccharides Studies on the Specificities of Some Lectins Anti-Glucuronyl Activity of Limulus polyphemus Agglutinin B.3. Lectin Binding Sites B.3.1. Binding Sites on Experimental Cells B.3.2. Binding Sites on Human Cells B.4. Lectin Binding to Cells B.4.1. Erythrocytes B.4.2. Lymphocytes B.4.3. Other Cells B.5. Lectins in Separation of Proteins B.6· Clinical Applications of Lectins Anti-Cancer Properties of the Toxic Lectins ABRIN and RICIN Determination and Differentiation of Lectin - Glycoconjugate Interaction by Laser Nephelometry A Nephelometric Assay of Concanavalin A Binding Proteins and its Use in Monitoring Inflammatory Disease Lectin Characterization of Abnormal Cystic Fibrosis a-L-Fucosidase Concanavalin A-Affinity Chromatography in the Diagnosis of Fetal Abnormalities Staining of Carbohydrate Moiety of Fibrinogen and Factor VIII in Electrophoretic Gels with Fluorescein-Labeled LectinsSection C. Techniques C.1.
