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Protides of the Biological Fluids contains the proceedings of the XVIIIth Colloquium held in Bruges, Belgium in 1970. The papers focus on protides of the biological fluids, with emphasis on three main topics related to protein chemistry: proteins during development and the recurrence of fetal proteins in cancer; protein-protein interactions; and trends and technical refinements in the insolubilization of proteins. This book is comprised of 95 chapters and begins with an assessment of the relationships and functions of the apoprotein and lipid moieties of lipoproteins, followed by a discussion on the characteristics and structure of the alpha-fetoproteins. The protein patterns in the post-natal period, as well as specific patterns encountered during development of the various organs, are then considered. Subsequent chapters explore the recurrence of various fetoproteins in hepatoma and in tumors of the digestive system; protein-protein interactions occurring during association or aggregation of some proteins such as myosin, fibrin, and casein; and preparation of insolubilized enzymes, together with the isolation and purification of antibodies. The final section is devoted to immunological studies and methods such as thin-layer ultracentrifugation. This monograph will be a useful resource for biologists and chemists alike.
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978-1-4831-4632-4 (9781483146324)
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PrefaceAcknowledgmentsAcademic Lecture The Apoprotein and Lipid Moieties of the LipoproteinsSection A: Proteins during Development A1. In General Variations on a Theme in Protein Structure A2. Foetal Proteins Some Physicochemical Characteristics of Human a1-Fetoprotein Purification and Chemical Characterization of Human Alpha-Fetoprotein Fetoprotein Level Development in the First Days of Life of Some Mammals HL-A Antigens in Human Foetuses Fetoproteins in Different Species of Mammals Development of the Plasma Protein Pattern in the Fetal Guinea Pig as Shown by Gel Electrofocusing/Electrophoresis Appearance and Disappearance of Organ-Specific Components during Kidney Tubulogenesis in Chick and Quail Embryos The Effect of Cellular Differentiation on the Mannosyl-Transferase Activity of Chick Embryo Cells Ontogenesis of Lysozyme in Man and Other Mammals Ontogenetic Sequence of Serum Esterases in Some Mammals Isoenzyme Studies in Human Embryonic Tissues and Cell Cultures Synthesis of Embryonic Hemoglobins in Mouse Embryos Active Immunization of Tadpoles against Frog Hemoglobin and Developmental Consequences Changes in the Protein Composition of the Mammalian Lens during Embryonic Development and Aging, with Special Reference to the Proteins of Low Molecular Weight Protein Linked Carbohydrates in the Developing Corneal Stroma of the Cattle Embryo A3. Proteins in Cord Blood Presence of IgG Subclasses and Clq in Human Cord Sera Biochemical Particularities of Glucose-6-Phosphate-Dehydrogenase (G.6PD) in Umbilical Cord Blood A4. Post-Natal Protein Patterns Monoclonal Immunoglobulins in Children A Pharmacokinetic Study of Intramuscular Injections of IgA and IgM Globulins in Newborn Children and Patients with an ADS (Antibody Deficiency Syndrome) Alpha1-Antitrypsin and Plasminogen Plasma Levels in Newborns Postnatal Development of Tissue-Specific Antigens of the Male Reproductive Accessory Glands Incorporation of the APR Sialoglycoproteins in Granulomatous Tissues Immunological Studies of Detoxifying Enzymes in Postnatal Development of Rat Liver Microsomes The Intravascular Mass of 21 Serum Proteins in Normal Mature and Premature Children A Polynomial Expression for the Serum Concentrations of 21 Serum Proteins from 1 to 93 Years of Age in Normal Females and Males A5. Proteins during Development of the Brain Rat Brain Proteins and Glycoproteins during Development Early Malnutrition and Rat Brain Proteins Catabolism of Proteins in Developing Rat Brain Developmental Changes in Rat BrainSection B: Recurrence of Fetal Proteins in Cancer Introductory Remarks on Fetal Proteins and Their Reappearance in Tumors B1. Primary Hepatoma a-Fetoprotein Production by Normal Liver and Liver Tumors Transitory Liver Antigens and Primary Hepatoma Use of the a-Feto Protein Test for the Diagnosis of Primary Liver Cancer Incidences of Three Different Fetal Proteins in Sera of Patients with Primary Hepatoma Resurgence of Two Fetal Type Aldolases in Hepatoma Assessment of Fetal and Cord Blood, Amniotic Fluid and Hepatoma Patients' Blood for 3 Fetal Antigens Occurrence of a1-Fetoprotein in Some Infants Suffering from Hepatopathy Serum Alpha-Foetoprotein (af) in Patients with Hepatoma from Djakarta Systematic a-Foetoprotein Research in 2500 Sera-Results Alpha-Foetoprotein, Alpha2-Globulin and a Beta-Globulin in Various Rat Tumors B2.