
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Stereoselective, Simultaneous Formation of sp3 and sp2 Centres
- 4 Conjugated and Non-conjugated Dienes
- 5 Polyenes
- 6 Allenes
- 7 Alkynes
- 8 Enynes
- References
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalised Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- ?-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates
- Aldol Reactions
- Conjugate Addition Reactions
- References
- Chapter 3 Alcohols, Halogeno Compounds, and Ethers
- 1 Alcohols
- Preparation
- By Addition to Olefins
- By Reduction of Carbonyl Compounds
- By Nucleophilic Alkylation
- Non Stereoselective Addition
- Stereoselective Addition
- By Opening of Epoxides
- Miscellaneous Methods
- Protection and Deprotection
- Oxidation and Deoxygenation
- 2 Halogeno Compounds
- Preparation and Reactions
- 3 Ethers
- Preparation
- References
- Chapter 4 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Acyclic Amines
- Aromatic Amines
- Allylic Amines
- Cyclic Amines
- Protecting Groups
- 2 Enamines
- 3 Alkyldiamines
- 4 Aminoalcohols
- 5 ß-Amino Aldehydes, Nitriles and Sulphoximines
- 6 Azo Compounds
- 7 Nitriles
- 8 Nitro Compounds
- 9 Nitroso Compounds and Nitramines
- 10 Hydrazines
- 11 Hydroxylamines
- 12 Imines
- 13 Amidines
- 14 Oximes
- 15 Carbodiimides
- 16 Azides
- 17 Thiocyanates and Isothiocyanates
- 18 Nitrones
- References
- Chapter 5 Organometallics in Synthesis
- Part I: The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerisations and Rearrangements
- 5 Carbon-Carbon Bond Forming Reactions
- Via Organometallic Electrophiles
- Via Organometallic Nucleophiles
- Via Coupling and Cycloaddition Reactions
- Via Carbonylation Reactions
- 6 Miscellaneous Reactions
- References
- Part II: Main Group Elements
- 1 Group I
- Lithium Amides
- Lithiated Aromatic and Heterocyclic Rings
- Lithium Enolates, Benzylic and Allylic Anions
- Di- and Trilithiated Anions
- Alkenyl and Alkynyl Anions
- Sodium and Potassium
- Anions Stabilised by Sulphur, Selenium and Phosphorus
- 2 Group II
- Magnesium and Calcium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium and Gallium
- 4 Group IV
- Silicon
- Allyl and Vinyl Silanes and Related Reagents
- Germanium
- Tin
- Lead
- 5 Group V
- Phosphorus
- Arsenic, Antimony and Bismuth
- 6 Group VI
- Sulphur
- Selenium and Tellurium
- References
- Chapter 6 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- 2 Four-membered Rings
- 3 Five-membered Rings
- Transition Metal Mediated Cyclisations
- Radical Cyclisations
- Other Routes to Five-membered Rings
- 4 Six-membered Rings
- Diels-Alder Reactions
- Other Routes to Six-membered Rings
- 5 Seven-membered, Medium and Large Rings
- Seven and Eight-membered Rings
- Sigmatropic Rearrangements
- Other Routes to Medium and Large Rings
- References
- Chapter 7 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Three-membered Rings
- Four-membered Rings
- Five-membered Rings
- Tetrahydrofurans
- Dihydrofurans and Benzofurans
- Five-membered Rings with More than One Oxygen
- Six-membered Rings
- Tetrahydropyrans
- Dihydropyrans
- Six-membered Rings with More than One Oxygen
- Medium- and Large-ring Ethers
- 2 Sulphur-containing Heterocycles
- 3 Heterocycles Containing More than One Heteroatom
- Nitrogen- and Oxygen-containing Rings
- Five-membered Rings
- Six-membered Rings
- Nitrogen- and Sulphur, Sulphur- and Oxygen-containing Rings
- 4 Nitrogen-containing Heterocycles
- Three- and Four-membered Rings
- Five-membered Rings
- Six-membered Rings Containing One Nitrogen
- Five- and Six-membered Rings Containing Two Nitrogen Atoms
- Seven-membered and Larger Rings
- ß-Lactams
- References
- Chapter 8 Highlights in the Total Synthesis of Natural Products
- 1 Terpenes
- 2 Alkaloids
- 3 Glycosides and Nucleosides
- 4 Spiroacetals
- 5 Macrolides
- 6 Macrolactams
- 7 Ionophores
- 8 FK-506
- 9 Prostaglandins, Leukotrienes and Steroids
- 10 Other Natural Products
- References
- Chapter 9 Reviews on General and Synthetic Methods
- 1 Design and Perspective
- 2 Olefinic Compounds
- 3 Halogeno Compounds
- 4 Alcohols
- 5 Aldehydes and Ketones and their Sulphur Derivatives
- 6 Heterocycles
- 7 Aromatic Chemistry
- 8 Organometallics
- General
- Main Group Elements
- Transition Elements
- 9 Asymmetric Synthesis
- 10 Enzymes in Synthesis
- 11 Oxidation
- 12 Cycloaddition Reactions
- 13 Electrochemistry
- 14 Radical Reactions in Synthesis
- 15 Natural Products
- 16 General and Miscellaneous
- Author Index
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