
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes and Non-conjugated Dienes
- 4 Allenes
- 5 Alkynes
- 6 Enynes and Diynes
- 7 Polyenes
- References
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Methods
- 2 Synthesis of Functionalised Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Aldol and Other Reactions of Enolates
- Conjugate Addition Reactions
- References
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Anhydrides
- Diacids
- Diacid Half Esters
- Hydroxy-acids
- Keto-acids
- Unsaturated Acids
- Aromatic Acids and Esters
- Arylacetic Acids and Esters
- Carboxylic Acid Protection
- 2 Carboxylic Acid esters
- Esterification
- General Synthesis of Esters,Thioesters, Dithioesters, and Selenoesters
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- 3 Lactones
- Butyrolactones
- a-Methylenebutyrolactones
- Butenolides
- Phthalides
- Tetronic Acids
- Valerolactones
- Macrolides
- 4 Carboxylic Acid Amides
- Amide Bond Formation
- Reactions
- 5 Amino-acids
- a-Amino-acids
- ß-Amino-acids
- ? and Other Amino-acids
- Asymmetric Hydrogenation of Unsaturated Amino-acid Derivatives
- Amino-acid Protection
- References
- Chapter 4 Alcohols, Halogeno Compounds, and Ethers
- 1 Alcohols
- Preparation by Addition to Alkenes
- Preparation by Reduction of Carbonyl Compounds
- Preparation by Nucleophilic Alkylation
- Preparation by Opening of Epoxides
- Miscellaneous Methods
- Protection and Deprotection
- Oxidation
- 2 Halogeno-compounds
- Preparation from Alcohols
- Preparation from Alkenes
- Interhalide Conversions
- Miscellaneous
- Preparation of a-Halo Carbonyl Compounds
- Preparation of Vinyl Halides
- Preparation of Other Unsaturated Halides
- 3 Ethers
- 4 Thiols
- 5 Thioethers
- References
- Chapter 5 Amines, Nitriles, and other Nitogen-containing Functional Groups
- 1 Amines
- Acyclic Amines
- Aromatic Amines
- Allylic, Homoallyic and Allenic Amines
- Cyclic Amines
- Protecting Groups
- 2 Enamines
- 3 Aminoalcohols
- 4 Azo Compounds
- 5 Nitriles and Isocyanides
- 6 Nitro- and Nitroso-compounds, and Nitramines
- 7 Hydrazines and Hydrazides
- 8 Hydroxylamines
- 9 Imines
- 10 Amidines
- 11 Oximes
- 12 Carbodimides
- 13 Azides and Diazonium Compounds
- 14 Isocyanates and Isothiocyanates
- 15 Nitrones
- References
- Chapter 6 Organometallics in Synthesis
- PART I: The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerisations and Rearrangments
- 5 Carbon-carbon Bond-forming Reactions
- via Organometallic Electrophiles
- via Organometallic Nucleophiles
- via Coupling and Cycloaddition Reactions
- via Carbonylation Reactions
- 6 Miscellaneous Reactions
- References
- PART II: Main Group Elements
- 1 Group I
- General Aspects
- Selective Lithiations
- Di and Trianions, Alkenyl, and Alkynyl Anions
- Sulphur Stabilized Anions
- 2 Group II
- Magnesium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium and Thallium
- 4 Group IV
- Silicon - General Aspects
- Allyl and Vinyl Silanes
- Other Silicone-containing Reagents
- Germanium, Tin, and Lead
- 5 Group V
- Phosphorus
- Arsenic, Antimony, and Bismuth
- 6 Group VI
- Sulphur
- Selenium and Tellurium
- References
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- 2 Four-membered Rings
- 3 Five-membered Rings
- Generated Methods
- Fused Five-memered Rings
- 4 Six-membered Rings
- Diels-Alder Reactions
- Other Syntheses of Six-membered Rings
- 5 Severn-membered, Medium, and Large Rings
- 6 Ring Expansion Methods
- References
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Three-membered Rings
- Four-membered Rings
- Five-membered Rings - Tetrahydrofurans
- Dihydrofurans and Benzofurans
- Five-membered Rings With More than One Oxygen
- Six-membered Rings - Tetrahydropyrans
- Dihydropyrans
- Six-membered Rings With More than One Oxygen
- Medium- and Large-Ring Ethers
- 2 Sulphur-containing Heterocycles
- 3 Heterocycles containing More than One Heteroatom
- Nitrogen- and Oxygen-containing Rings
- Five-membered Rings
- Six-membered Rings
- Nitrogen- and Sulphur, and Sulphur- and Oxygen-containing Rings
- 4 Nitrogen-containing Heterocycles
- Three- and Four-membered Rings
- Five-membered Rings
- Six-membered Rings
- Six-membered Rings containing Two Nitrogens
- Seven- and Eight-membered Rings
- ß-Lactams, Penicillins, Cephalosporins and Related Compounds
- References
- Chapter 9 Highlights in Total Synthesis of Natural Products
- 1 Terpenes
- 2 Alkaloids
- 3 Spiroacetals
- 4 Macrolides
- 5 Ionophores
- 6 Other Natural Products
- References
- Reviews on General and Synthetic Methods
- 1 Fluoroorganic Compounds
- 2 Carbonyl Compounds
- 3 Peptides
- 4 Organometallics
- General
- Main Group Elements
- Transition Elements
- 5 Cycloaddition and other Pericycle Processes
- 6 Macrocycles
- 7 Heterocycles
- 8 Natural Products
- 9 Asymmetric and Selective Synthesis
- 10 Sugars
- 11 Photochemistry, Electrochemistry, and Radicals
- 12 Reagents
- 13 Oxidation and Reduction
- 14 Resolution Methods
- 15 General
- 16 Miscellaneous
- Author Index
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