
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenes
- 6 Alkynes
- 7 Enynes and Diynes
- 8 Polynes
- Reference
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalised Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates
- Aldol Reactions
- Conjugate Addition Reactions
- References
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Diacids and Half-esters
- Hydroxy-acids
- Keto-acids
- Unsaturated Acids
- Aromatic Acids
- Arylacetic Acids and Esters
- Acid Anhydrides
- Carboxylic Acid Protection
- 2 Carboxylic Acid Esters
- Esterification
- General Synthesis
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Aromatic Esters
- Thioesters, Selenoesters, and Related Compounds
- 3 Lactones
- ß-Lactones
- Butyrolactones
- a-Methylenebutyrolactones
- Butenolides
- Tetronic Acids
- Phthalides
- Valerolactones
- Macrolides
- 4 Carboxylic Acid Amides
- 5 Amino-acids
- a-Amino-acids
- ß-Amino-acids
- ?-Amino-acids
- Unsaturated Amino-acids
- Asymmetric Hydrogenation
- Amino-acid Protection
- References
- Chapter 4 Alcohols, Halogeno Compounds, and Ethers
- 1 Alcohols
- Preparation by Additions to Alkenes
- Preparation by Reduction of Carbonyl Compounds
- Preparation by Nucleophilic Alkylation
- Miscellaneous Methods
- Protection and Deprotection
- Reactions of Alcohols
- Oxidation
- Deoxygenation
- Miscellaneous Reactions
- 2 Halogeno-compounds
- Preparation from Alcohols
- Preparation by Addition to Unsaturated Substrates
- Interhalide Conversions
- Halogenation of a- to Carbonyl Groups
- Miscellaneous Methods
- Reactions Elimination and Dehalogenation
- Coupling Reactions
- Miscellaneous Reactions
- 3 Ethers
- Preparation
- Reactions
- 4 Thiols
- 5 Thioethers
- References
- Chapter 5 Amines, Nitriles, and other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- Diamines
- Polyamines
- 2 Enamines
- 3 Allylamines, Homoallylamines, and Alkynlamines
- 4 Amino-alcohols
- 5 Amino-carbonyl Compounds
- 6 Amides and Thioamides
- 7 Nitriles and Isocyanides
- 8 Nitro- and Nitroso-compounds
- 9 Hydrazines and Hydrazones
- 10 Hydroxylamines and Hydroxamic acids
- 11 Imines, Iminium Salts, and Related Compounds
- 12 Oximes
- 13 Carbodi-imides
- 14 Azides and Diazo-compounds
- 15 Azo- and Azoxy-compounds
- 16 Isocyanates, Thiocyanates, and Isothiocyanates
- 17 Nitrones
- 18 Nitrates and Nitrites
- References
- Chapter 6 Organometallics in Synthesis
- PART I: The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerisations and Rearrangements
- 5 Carbon-carbon Bond-forming Reactions
- via Organometallic Electrophiles
- via Organometallic Nucleophiles
- via Coupling and Cycloaddition Reactions
- via Carbonylation Reactions
- 6 Miscellaneous Reactions
- References
- PART II: Main Group Elements
- 1 Group I
- Selective Lithiation
- Dianions, Alkenyl, and Alkynyl Anions
- Sodium and Potassium
- Sulphur and Selenium Stabilised Anions
- 2 Group II
- Beryllium, Magnesium, and Calcium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium and Thallium
- 4 Group IV
- Silicon
- Allyl, Propargyl, and Benzyl Silanes
- Vinyl, Alkynyl, and Allenylsilanes
- Other Silicon-containing Reagents
- Tin and Lead
- 5 Group V
- Phosphorus
- Antimony and Bismuth
- 6 Group VI
- Sulphur
- Selenium and Tellurium
- References
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- General Methods
- 2 Four-membered Rings
- 3 Five-membered Rings
- General Methods
- Fused Five-membered Rings
- 4 Six-membered Rings
- Diels-Alder Reactions
- Other Syntheses of Six-membered Rings
- Polyene Cyclisation
- 5 Seven-membered, Medium, and Large Rings
- 6 Ring Expansion Methods and Spiro-ring Compounds
- References
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Three-membered Rings
- Five-membered Rings
- Tetrahydrofurans
- Dihydrofurans
- Five-membered Rings containing more than
- One Oxygen
- Six-membered Rings
- Tetrahydropyrans and Dihydropyrans
- Pyrans
- Polyether Ionophores
- Medium Rings
- 2 Sulphur-containing Heterocycles
- 3 Heterocycles containing more than One Heteroatom
- Nitrogen- and Oxygen-containing Rings
- Nitrogen- and Sulphur-containing Rings
- Oxygen and Sulphur, and Oxygen-, Nitrogen-, and Sulphur-containing Rings
- 4 Nitrogen-containing Heterocycles
- Three-membered Rings
- Five-membered Rings containing more than One Nitrogen
- Six-membered Rings
- Six-membered Rings containing more than One Nitrogen
- Seven-membered Rings
- ß-Lactams
- References
- Chapter 9 Highlights in Total Synthesis of Natural Products
- 1 Terpenes
- 2 Steroids
- 3 Alkaloids
- 4 Prostaglandins
- 5 Spiroacetals
- 6 Ionophores and Macrolides
- 7 Other Natural Products
- References
- Reviews on General and Synthetic Methods
- 1 Esters and Lactones
- 2 Fluoroorganic Compounds
- 3 Ketenes
- 4 Nitrogen-containing Functional Groups
- 5 Organometallics
- 6 Carbocyclic Ring Synthesis
- 7 Heterocycles
- 8 Natural Products
- 9 Asymmetric and Selective Synthesis
- 10 Enzymic Reactions
- 11 Reduction
- 12 Photochemistry, Electrochemistry, and Sonochemistry
- 13 Radical Chemistry
- 14 General
- 15 Miscellaneous
- Author Index
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