
General and Synthetic Methods
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Content
- General and Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefins
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenes
- 6 Alkynes
- 7 Enynes and Diynes
- 8 Polyenes
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalized Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates
- Aldol Reactions
- Conjugate Addition Reactions
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Diacids
- Hydroxy-acids
- Keto-acids
- Unsaturated Acids
- Anhydrides
- Carboxylic Acid Protection
- Decarboxylation
- 2 Carboxylic Acid Esters
- Esterification
- General Synthesis
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Aromatic Esters
- Acetylenic Esters
- Allenic Esters and Dienoates
- Thioesters
- 3 Lactones
- ß-Lactones
- Butyrolactones
- a-Methylenebutyrolactones
- Butenolides
- Tetronic Acids
- Phthalides
- Valerolactones
- Macrolides
- 4 Carboxylic Acid Amides
- General Synthesis
- Hydroxy-amides
- Keto-amides
- Unsaturated Amides
- Thio- and Seleno-amides
- 5 Amino-acids
- a-Amino-acids
- ß-Amino-acids
- ?-Amino-acids
- Unsaturated a-Amino-acids
- Carboxylic Acid Protection
- Amino Group Protection
- Thiol Group Protection
- Chapter 4 Alcohols, Halogeno-compounds, and Ethers
- 1 Alcohols
- Preparation by Addition to Alkenes
- Preparation by Reduction of Carbonyl Compounds
- Chemoselective Carbonyl Reductions
- Stereoselective Carbonyl Reductions
- Asymmetric Carbonyl Reductions
- Enzymic Asymmetric Carbonyl Reductions
- Preparation by Nucleophilic Addition
- General Methods of Preparation
- Protection and Deprotection
- Reactions of Alcohols
- Oxidation
- Hydrogenation and Deoxygenation
- Miscellaneous Reactions
- 2 Halogeno-compounds
- Preparation from Alcohols
- Interhalide Conversions
- Miscellaneous Preparations
- Reactions
- Dehalogenation
- Acylation and Coupling Reactions
- Miscellaneous Reactions
- 3 Ethers
- Preparation
- Reactions
- 4 Thiols and Thioethers
- Chapter 5 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- Diamines
- 2 Enamines
- 3 Allylamines, Homoallylamines, and Alkynylamines
- 4 Amino-alcohols and Related Compounds
- 5 Amino-carbonyl Compounds
- 6 Amino-esters
- 7 Amides, Thioamides, and Selenocarboxamides
- 8 Nitriles and Isocyanides
- 9 Nitro- and Nitroso-compounds
- 10 Hydrazines and Hydrazones
- 11 Hydroxylamines and Hydroxamic Acids
- 12 Imines, Iminium Salts, and Related Compounds
- 13 Oximes
- 14 Carbodi-imides
- 15 Azides and Diazo-compounds
- 16 Azo- and Azoxy-compounds
- 17 Isocyanates, Thiocyanates, Isothiocyanates, Selenocyanates, and Isoselenocyanates
- 18 Nitrones
- 19 Nitrates and Nitrites
- Chapter 6 Organometallics in Synthesis
- PART I: The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Rearrangements and Isomerizations
- 5 Carbon-Carbon Bond Formation
- via Organometallic Electrophiles
- via Organometallic Nucleophiles
- via Coupling Reactions
- via Carbonylation Reactions
- 6 Miscellaneous Reactions
- PART II: Main Group Elements
- 1 Group I
- Selective Lithiations
- Dianions and Alkenyl and Alkynyl Anions
- Sulphur-stabilized Anions
- 2 Group II
- Magnesium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium and Thallium
- 4 Group IV
- Silicon
- Allyl- and Vinyl-silanes
- Other Silicon-containing Reagents
- Tin and Lead
- 5 Group V
- Phosphorus
- Arsenic, Antimony, and Bismuth
- 6 Group VI
- Sulphur
- Selenium and Tellurium
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- 2 Four-membered Rings
- 3 Five-membered Rings
- General Methods
- Fused Five-membered Rings
- Naturally Occurring Fused Cyclopentanoids
- 4 Six-membered Rings
- Diels-Alder Reactions
- Other Syntheses of Six-membered Rings
- Polyene Cyclizations
- 5 Seven-membered, Medium, and Large Rings
- 6 Ring Expansion Methods
- 7 Spiro-ring Compounds
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Three- and Four-membered Rings
- Five-membered Rings
- Tetrahydrofurans
- Dihydrofurans
- Six-membered Rings
- Tetrahydropyrans
- Dihydropyrans
- [5.n]Spiroacetals
- Six-membered Rings with More than One Oxygen
- Seven- and Eight-membered Rings
- 2 Sulphur-containing Heterocycles
- 3 Heterocycles Containing More than One Heteroatom
- Nitrogen- and Oxygen-containing Rings
- Five-membered Rings
- Six- and Seven-membered Rings
- Nitrogen- and Sulphur-containing Rings
- Oxygen- and Sulphur-, and Nitrogen-, Oxygen-, and Sulphur-containing Rings
- 4 Nitrogen-containing Heterocycles
- Three- and Four-membered Rings
- Five-membered Rings
- Six-membered Rings
- Six-membered Rings Containing Two Nitrogens
- 5 ß-Lactams, Penicillins, Cephalosporins, and Related Compounds
- Chapter 9 Highlights in Total Synthesis of Natural Products
- 1 Terpenes
- 2 Steroids
- 3 Anthracyclinones and Naphthaquinones
- 4 Alkaloids
- 5 Prostaglandins and Thromboxanes
- 6 Spiroacetals
- 7 Sugars
- 8 Macrolides and Ionophores
- 9 Other Natural Products
- Reviews on General and Synthetic Methods
- 1 Olefins
- 2 Aldehydes and Ketones
- 3 Esters and Lactones
- 4 Fluoroorganic Compounds
- 5 Organometallics
- General
- Transition Elements
- Main Group Elements
- 6 Carbocyclic Ring Synthesis
- 7 Heterocycles
- 8 Natural Products
- 9 Enzymic Reactions and Asymmetric Synthesis
- 10 Oxidation
- 11 Reduction
- 12 Protective Groups
- 13 Radical Chemistry
- 14 General
- 15 Miscellaneous
- Author Index
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