
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenic Hydrocarbons
- 6 Acetylenic Hydrocarbons
- 7 Enynes and Diynes
- 8 Polyenes
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalized Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substitued Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates
- Aldol Reactions
- Conjugate Addition Reactions
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Diacids
- Hydroxy-acids
- Keto-acids
- Unsaturated Aliphatic Acids
- Aromatic Acids
- Acid Chlorides and Anhydrides
- Decarboxylation
- Carboxylic Acid Group Protection
- 2 Esters
- Esterification
- General Synthesis
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Thioesters
- 3 Lactones
- Butyrolactones
- a-Methylenebutyrolactones
- Butenolides
- Tetronic Acids
- Phthalides
- Valerolactones
- Macrolides
- 4 Amides
- Synthesis
- Thioamides
- Amide (Peptide) Bond Formation
- 5 Amino-acids
- General Synthesis
- Unsaturated Amino-acids
- Asymmetric Hydrogenation
- Amino-acid Protection
- Chapter 4 Alcohols, Halogeno-compounds, and Ethers
- 1 Alcohols
- Preparation
- By Addition to Alkenes
- By Reduction of Carbonyl Compounds
- Chemoselective Carbonyl Reductions
- Stereoselective Carbonyl Reductions
- Asymmetric Carbonyl Reductions
- By Nucleophilic Additions
- Miscellaneous Methods
- Protection and Deprotection
- Reactions
- Oxidation
- Deoxygenation
- Miscellaneous Reactions
- 2 Halogeno-compounds
- Preparation
- From Alcohols
- By Addition to Unsaturated Substrates
- Interhalide Conversions
- Miscellaneous Methods
- Reactions
- 3 Ethers
- Preparation
- Reactions
- 4 Thiols
- 5 Thioethers
- 6 Crown Ethers, Thia-crown Ethers, and Related Structures
- Chapter 5 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- Diamines
- 2 Enamines
- 3 Allylamines, Homoallylamines, and Alkynylamines
- 4 Amino-alcohols
- 5 Amino-carbonyl Compounds
- 6 Amides and Thioamides
- 7 Nitriles and Isocyanides
- 8 Nitro- and Nitroso-compounds
- 9 Hydrazines and Hydrazones
- 10 Hydroxylamines and Hydroxamic Acids
- 11 Imines, Iminium Salts, and Related Compounds
- 12 Oximes
- 13 Carbodi-imides
- 14 Azides and Diazo-compounds
- 15 Azo- and Azoxy-compounds
- 16 Isocyanates, Thiocyanates, Isothiocyanates, and Selenocyanates
- 17 Nitrones
- 18 Nitrates and Nitrites
- Chapter 6 Organometallics in Synthesis
- PART I: The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerizations and Rearrangements
- 5 Carbon-Carbon Bond-forming Reactions
- via Organometallic Electrophiles
- via Organometallic Nucleophiles
- via Coupling Reactions
- via Carbonylation Reactions
- 6 Miscellaneous Reactions
- PART II: Main Group Elements
- 1 Group I
- Selective Lithiations
- Synthetic Equivalents
- Miscellaneous
- 2 Group II
- Magnesium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium
- 4 Group IV
- Allylsilanes
- Vinylsilanes
- Silicon-based Reagents
- Miscellaneous Silicon Compounds
- Tin
- 5 Group V
- Phosphorus
- 6 Group VI
- Sulphur
- Selenium
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- General Methods
- 2 Four-membered Rings
- 3 Five-membered Rings
- General Methods
- Fused Five-membered Rings
- Naturally Occurring Fused Cyclopentanoids
- 4 Six-membered Rings
- Diels-Alder Reactions
- Intramolecular Diels-Alder Reactions
- Other Syntheses of Six-membered Rings
- Polyene Cyclizations
- 5 Seven-membered, Medium, and Large Rings
- 6 Ring-expansion Methods
- 7 Spiro-ring Compounds
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Hetrocycles
- Three- and Four-membered Rings
- Five-membered Rings
- Tetrahydrofurans
- Dihydrofurans
- Six-membered Rings
- Tetrahydropyrans
- Dihydropyrans
- [5.n]Spiroacetals
- Six-membered Rings Containing More than One Oxygen
- Seven- and Eight-membered Rings
- 2 Sulphur-containing Hetrocycles
- 3 Rings with More than One Heteroatom
- Nitrogen- and Oxygen-containing Rings
- Three- and Four-membered Rings
- Five-membered Rings
- Six-membered and Larger Rings
- Oxygen and Sulphur-, and Nitrogen and Sulphur-containing Rings
- 4 Nitrogen-containing Heterocycles
- Three-membered Rings
- Four-membered Rings
- Five-membered Rings
- Five-membered Rings Containing More than One Nitrogen
- Six-membered Rings Containing One Nitrogen
- Six-membered Rings Containing More than One Nitrogen
- Medium-ring Nitrogen Heterocycles
- Rings Containing One Nitrogen
- Rings Containing Two Nitrogens
- 5 ß-Lactams, Penicillins, Cephalosporins, and Related Compounds
- Chapter 9 Highlights in Total Synthesis of Natural Products
- 1 Introduction
- 2 Terpenes
- 3 Steroids
- 4 Anthracyclinones
- 5 Alkaloids
- 6 Prostanoids
- 7 Spiroacetals
- 8 Lignans
- 9 Polyols
- 10 Macrolides and Ionophores
- 11 Other Natural Products
- Reviews on General and Synthetic Methods
- 1 Olefins
- 2 Aldehydes and Ketones
- 3 Nitrogen-containing Functional Groups
- 4 Organometallics
- General
- Transition Elements
- Main Group Elements
- 5 Carbocycles
- 6 Cycloaddition Reactions
- 7 Heterocycles
- 8 Prostaglandins
- 9 Sugars
- 10 Alkaloids
- 11 Enzymic Reactions and Asymmetric Synthesis
- 12 Photochemistry and Electrochemistry
- 13 General
- 14 Miscellaneous
- Author Index
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