
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenic Hydrocarbons
- 6 Acetylenic Hydrocarbons
- 7 Enynes and Diynes
- 8 Polyenes
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalized Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates
- Aldol Reactions
- Conjugate Addition Reactions
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Acid Chlorides and Anhydrides
- Diacids
- Hydroxy-acids
- Keto-acids
- Unsaturated Acids
- Protection and Deprotection
- Decarboxylation
- 2 Esters
- Esterification
- General Synthesis
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Thioesters
- 3 Lactones
- ß-Lactones
- Butyrolactones
- a-Methylenebutyrolactones
- Butenolides and Phthalides
- Tetronic acids
- Valerolactones
- Macrolides
- 4 Carboxylic Acid Amides
- Synthesis
- Reactions
- Thioamides
- Peptide Bond Formation
- 5 Amino-acids
- Synthesis
- Dehydroamino-acids
- Asymmetric Hydrogenation
- Protection and Deprotection
- Chapter 4 Alcohols, Halogeno-compounds, and Ethers
- 1 Alcohols
- Preparation by Addition to Alkenes
- Preparation by Reduction of Carbonyl Compounds
- Chemoselective Carbonyl Reductions
- Stereoselective Carbonyl Reductions
- Asymmetric Carbonyl Reductions
- Enzymic Asymmetric Carbonyl Reductions
- Preparation by Nucleophilic Addition
- Allylic Alchols
- Homoallylic Alcohols
- Other Unsaturated Alcohols
- Diols
- General Methods of Preparation
- Allylic Alcohols
- Homoallylic and Other Unsaturated Alcohols
- Diols
- Protection and Deprotection
- Reactions of Alcohols
- Oxidation
- Hydrogenolysis and Deoxygenation
- Halogenation
- Chiral Auxilliaries
- Other Reactions
- 2 Halogeno Compounds
- Preparation
- Reactions
- 3 Ethers
- 4 Thiols and Thioethers
- 5 Macrocyclic Polyethers
- Chapter 5 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- 2 Enamines
- 3 Allylamines, Homoallylamines, and Alkynylamines
- 4 Amino-alcohols
- 5 Amino-aldehydes and Amino-ketones
- 6 Amides and Thioamides
- 7 Nitriles and Isocyanides
- 8 Nitro- and Nitroso-compounds
- 9 Hydrazines
- 10 Hydroxylamines and Hydroxamic Acids
- 11 Imines, Iminium Salts, and Related Compounds
- 12 Oximes
- 13 Carbodi-imides
- 14 Azides and Diazo-compounds
- 15 Azo- and Azoxy-compounds
- 16 Isocyanates, Thiocyanates, Isothiocyanates, and Selenocyanates
- 17 Nitrones
- 18 Nitrates and Nitrites
- Chapter 6 Organometallics in Synthesis
- Part I The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerizations and Rearrangements
- 5 Carbon-Carbon Bond Formation
- via Organometallic Electrophiles
- via Organometallic Nucleophiles
- via Coupling Reactions
- via Carbonylation and Related Reactions
- 6 Synthesis of Heterocycles
- 7 Miscellaneous Reactions
- Part II Main Group Elements
- 1 Group I
- Selective Lithiation
- Synthetic Equivalents
- Sulphur-stabilized Anions and Dianions
- Miscellaneous Reactions
- 2 Group II
- Magnesium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium
- 4 Group IV
- Silicon
- Tin
- 5 Group V
- Phosphorus
- 6 Group VI
- Sulphur
- Selenium
- Tellurium
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- 2 Four-membered Rings
- 3 Five-membered Rings
- Fused Five-membered Rings
- Naturally Occurring Fused Cyclopentanoids
- 4 Six-membered Rings
- Diels-Alder Reactions
- Intramolecular Diels-Alder Reactions
- Other Six-membered Ring Syntheses
- Steroids
- 5 Seven-membered, Medium, and Large Rings
- 6 Ring Expansion Methods
- 7 Spiro-ring Compounds
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Oxiranes
- Four-membered Rings
- Five-membered Rings
- Tetrahydrofurans
- Dihydrofurans
- Five-membered Rings with More than One Oxygen Atom
- Six-membered Rings
- Tetrahydropyrans
- Dihydropyrans
- [5 .n]-Spiroacetals
- Six-membered Rings with More than One Oxygen Atom
- Seven- and Eight-membered Rings
- 2 Sulphur-containing Heterocycles
- 3 Heterocycles Containing More than One Heteroatom
- Nitrogen- and Oxygen-containing Rings
- Three-membered Rings
- Five-membered Rings
- Six- and Eight-membered Rings
- Oxygen and Sulphur-, and Nitrogen and Sulphur-containing Rings
- 4 Nitrogen-containing Heterocycles
- Three-membered Rings
- Four-membered Rings
- Five-membered Rings Containing One Nitrogen Atom
- Five-membered Rings Containing More than One Nitrogen Atom
- Six-membered Rings Containing More than One Nitrogen Atom
- Medium Ring Nitrogen Heterocycles
- Rings Containing One Nitrogen Atom
- Rings Containing More than One Nitrogen Atom
- 5 ß-Lactams, Penicillins, Cephalosporins and Related Compounds
- Chapter9 Highlights in Total Synthesis of Natural Products
- 1 Introduction
- 2 Terpenes
- 3 Steroids
- 4 Anthracyclinones
- 5 Alkaloids
- 6 Prostaglandins and Leukotrienes
- 7 Spiroacetals
- 8 Pseudomonic Acids
- 9 Sugars
- 10 Macrolides and Ionophores
- 11 Other Natural Products
- Reviews on General and Synthetic Methods
- 1 Olefins
- 2 Aldehydes and Ketones
- 3 Carboxylic Acids
- 4 Alcohols, Halogeno-compounds, and Ethers
- 5 Nitrogen-containing Functional Groups
- 6 Organometallics
- General
- Transition Elements
- Boron and Thallium
- 7 Ring Synthesis
- 8 Heterocycles
- 9 Electrochemical Methods
- 10 Photochemical Methods
- 11 Peptide Synthesis
- 12 Asymmetric Synthesis
- 13 General
- 14 Miscellaneous
- Author Index
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