
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenic Hydrocarbons
- 6 Acetylenic Hydrocarbons
- 7 Enynes and Diynes
- 8 Polyenes
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Methods Involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalized Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates and Enolate Equivalents
- Aldol Reactions
- Conjugate Addition Reactions
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Diacids
- Hydroxy -acids
- Keto-acids
- Unsaturated Acids
- Decarboxylation
- Protection and Deprotection
- 2 Esters
- Esterification
- General Synthesis and Reactions
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Thioesters
- Vinylogous Esters
- 3 Lactones
- General Synthesis
- ß-Lactones
- Butyrolactones
- Butenolides
- Phthalides
- Tetronic Acids
- a-Methylenebutyrolactones
- Valerolactones
- 4 Macrolides
- 5 Carboxylic Acid Amines
- Synthesis
- Macrocyclic Lactams
- Reactions
- 6 Amino-acids
- Synthesis
- Unsaturated a-Amino-acids
- Asymmetric Hydrogenation
- Protection and Deprotection
- Peptide Synthesis
- Chapter 4 Alcohols, Halogeno-compounds, and Ethers
- 1 Alcohols
- Preparation
- Carbonyl Group Reduction
- Asymmetric Reductions
- Allylic and a-Allenic Alcohols
- Other Unsaturated Alcohols
- Diols
- Protection
- Reactions
- 2 Halogeno-compounds
- Preparation
- Vinyl halides
- Reactions
- Halogen Displacement by Nucleophiles-Phase-transfer Methods
- 3 Ethers
- Preparation
- Reactions
- 4 Thiols and Thioethers
- 5 Macrocylic 'Crown' Polyethers and Related Compounds
- Synthesis
- Applications
- Chapter 5 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- 2 Nitriles and Isocyanides
- 3 Nitro- and Nitroso-compounds
- 4 Hydroxylamines
- 5 Hydrazines
- 6 Azo-compounds
- 7 Imines
- 8 Carbodi-imides
- 9 Enamines
- 10 Azides and Diazonium Compounds
- 11 Isocyanates, Thiocyanates, Isothiocyanates, Selenocyanates, and Isoselenocyanates
- 12 Nitrones
- 13 Nitrates
- Chapter 6 Organometallics in Synthesis
- Part I The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerization and Rearrangement
- 5 Carbon-Carbon Bond-forming Reactions
- 6 Synthesis of Heterocycles
- 7 Miscellaneous Reactions
- Part II Main Group Elements
- 1 Group I
- Selective Lithiation
- Alkenyl Anions and Synthetic Equivalents
- Miscellaneous
- 2 Group II
- Magnesium
- Zinc and Mercury
- 3 Group III
- Boron
- Aluminium and Thallium
- 4 Group IV
- Silicon
- C-C Bond Formation
- Silicon-based Reagents
- Tin and Lead
- 5 Group V
- Phosphorus
- Arsenic and Bismuth
- 6 Group VI
- Sulphur
- Selenium
- Tellurium
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- General Methods
- Natural Cyclopropanes
- 2 Four-membered Rings
- 3 Five-membered Rings
- Fused Five-membered Rings
- Naturally Occurring Fused Cyclopentanoids
- 4 Six-membered Rings
- Diels-Alder Reactions
- Other Six-membered Ring Synthesis
- Steroids
- Anthracyclines
- 5 Polyene Cyclizations
- 6 Seven-membered Rings
- 7 Ring Expansion Methods
- 8 Medium and Large Rings
- 9 Spiro-ring Compounds
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-Containing Heterocycles
- Oxirans
- Oxetans
- Five-membered Rings
- Six-membered Rings
- 2 Nitrogen-containing Heterocycles
- Three-membered Rings
- Four-membered Rings
- Five-membered Rings
- Five-membered Rings with two or more Nitrogen Atoms
- Six-membered Rings
- 3 Sulphur-containing Heterocycles
- Thiirans, Thietans, and Thiophen Derivatives
- Thiapyran Derivatives
- 4 Ring Systems of more than Six Members Containing Heteroatoms of One Type
- Benzoxepins
- Rings Containing Nitrogen
- Rings Containing Sulphur
- 5 Heterocycles Containing Both Oxygen and Nitrogen
- Three-membered Rings
- Five-membered Rings
- Six-membered Rings
- 6 Heterocycles Containing Both Oxygen and Sulphur
- Four-membered Rings
- Six-membered Rings
- 7 Heterocycles Containing Both Nitrogen and Sulphur
- Three- and Four-membered Rings
- Five-membered Rings
- Six-membered Rings
- Seven-membered Rings
- 8 Heterocycles Containing Nitrogen, Oxygen, and Sulphur
- Chapter 9 Highlights in Total Synthesis of Natural Products
- 1 Introduction
- 2 Terpene and Other Carbocyclic Systems
- 3 Steroids
- 4 Anthracyclinones
- 5 Alkaloids
- 6 Stereochemically-complex Oxygen Heterocycles
- Reviews on General and Synthetic Methods
- 1 Olefins
- 2 Aldehydes and Ketones
- 3 Nitrogen-containing Functional Groups
- 4 Organometallics
- Boron
- Silicon
- Tin
- Transition Elements
- 5 Ring Synthesis
- 6 Heterocycles
- 7 Photochemical Methods
- 8 Oxidation
- 9 Asymmetric Synthesis
- 10 Polymer Supports in Synthesis
- 11 Protecting Groups
- 12 Natural Product Synthesis
- 13 General
- 14 Miscellaneous
- Author Index
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