
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenic Hydrocarbons
- 6 Acetylenic Hydrocarbons
- 7 Enynes and Diynes
- 8 Polyenes
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Reductive Methods
- Aldehydes from Acid Derivatives
- Ketones from Acid Equivalents
- Methods involving Umpolung
- Other Methods
- Cyclic Ketones
- 2 Synthesis of Functionalized Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- Dicarbonyl Compounds
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates and Enolate Equivalents
- Aldol Reactions
- Conjugate Addition Reactions
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Diacids
- Hydroxy-acids
- Keto-acids
- Unsaturated Acids
- Decarboxylation
- Protection and Deprotection
- 2 Lactones
- General Synthesis
- ß-Lactones
- Butyrolactones
- Butenolides
- Phthalides
- Tetronic Acids
- a-Methylenebutyrolactones
- Valerolactones
- 3 Macrolides
- 4 Esters
- Esterification
- General Synthesis
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Thioesters, Selenoesters, and Thioamides
- 5 Carboxylic Acid Amides
- Synthesis
- Reactions
- Amide- and Peptide-Bond Formation
- 6 Amino-acids
- Synthesis
- Unsaturated a-Amino-acids
- Asymmetric Hydrogenation
- Protection and Deprotection
- Chapter 4 Alcohols, Halogeno-compounds, and Ethers
- 1 Alcohols
- Preparation
- Carbonyl Group Reduction
- Asymmetric Reductions
- Allylic Alcohols
- Other Unsaturated Alcohols
- 1,2-, 1,3-, and Other Diols
- Protection
- Reactions
- 2 Halogeno-compounds
- Preparation
- From Amines or Alcohols
- Other Methods
- Vinyl Halides
- Reactions
- Halogen Displacement by Nucleophiles-Phase-transfer Methods
- 3 Ethers
- Preparation
- Reactions
- 4 Thiols and Thioethers
- Preparation
- 5 Macrocyclic 'Crown' Polyethers and Related Compounds
- Synthesis
- Applications
- Chapter 5 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- 2 Nitriles
- 3 Nitro- and Nitroso-compounds
- 4 Hydrazines
- 5 Azo-compounds
- 6 Imines
- 7 Enamines
- 8 Azides and Diazonium Compounds
- 9 Isocyanates, Thiocyanates, and Isothiocyanates
- 10 Nitrones
- 11 Nitrates
- Chapter 6 Organometallics in Synthesis
- Part I The Transition Elements
- 1 Introduction
- 2 Reduction
- 3 Oxidation
- 4 Isomerization and Rearrangement
- 5 Carbon-Carbon Bond-forming Reactions
- 6 Synthesis of Heterocycles
- 7 Miscellaneous Reactions
- Part II Main Group Elements
- 1 Introduction
- 2 Group I
- Regio- and Stereo-specific Lithiation
- Synthetic Equivalents
- Conjugate Addition
- Miscellaneous
- 3 Group II
- Magnesium
- Zinc and Mercury
- 4 Group III
- Boron
- Aluminium
- Thallium
- 5 Group IV
- Silicon
- C-C Bond Formation
- Reagents for Functional Group Modifications
- Tin and Lead
- 6 Group V
- Phosphorus
- Bismuth
- 7 Group VI
- Sulphur
- Selenium
- Tellurium
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Three-membered Rings
- General Methods
- Natural Cyclopropanes
- 2 Four-membered Rings
- 3 Five-membered Rings
- General Methods
- Fused Five-membered Rings
- Prostaglandins, Methylenomycins, and Related Compounds
- 4 Six-membered Rings
- Diels-Alder Reactions
- Other Six-membered Ring Synthesis
- Anthracyclines
- 5 Polyene Cyclization and Polycyclic Synthesis
- 6 Seven-membered Rings
- 7 Medium and Large Rings
- 8 Spiro-ring Annulations
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Oxirans
- Oxetans
- Five-membered Ring Oxygen Heterocycles
- Six-membered Ring Oxygen Heterocycles
- 2 ß-Lactams and Related Compounds
- 3 Compounds Containing Sulphur
- Three-membered Ring Sulphur Heterocycles
- Four-membered Ring Sulphur Heterocycles
- Five-membered Ring Sulphur Heterocycles
- Six-membered Ring Sulphur Heterocycles
- 4 Nitrogen-containing Heterocycles
- Three-membered Ring Nitrogen Heterocycles
- Four-membered Ring Nitrogen Heterocycles
- Pyrrolidines and Related Compounds
- Piperidines and Related Heterocycles
- 5 Heterocycles with more than One Heteroatom
- Four-membered Rings
- Five-membered Rings
- Six-membered Rings
- Seven-membered Rings
- 6 Medium Ring Heterocyclic Compounds
- Oxepines
- Sulphur Compounds
- Nitrogen Compounds
- Miscellaneous
- 7 Macrocyclic Heterocycles
- Crown Ethers
- Polyaza- and Polyhetero-crown Compounds
- Macrolides
- Chapter 9 Strategy and Design in Synthesis
- 1 Introduction
- 1 Synthesis Dominated by a Single Strategy
- The Reconnective Strategy
- The Key Reaction Strategy
- Intramolecular Diels-Alder Routes
- Intermolecular Diels-Alder Routes
- Routes Based on 1,3-Dipolar Additions
- Syntheses Based on Claisen and Cope Rearrangements
- Syntheses Based on Other Key Reactions
- 3 Other Selected Syntheses
- The Skeleton is the Problem
- The Stereochemistry is the Problem
- 4 Computers and Synthetic Planning
- Reviews on General Synthetic Methods
- 1 Olefins
- 2 Ethers
- 3 Peptides
- 4 Nitrogen-containing Functional Groups
- 5 Organometallics
- General
- Silicon, Phosphorus, and Sulphur
- Transition Elements
- 6 Ring Synthesis
- 7 Heterocycles
- 8 Photochemistry
- 9 Stereochemistry
- 10 General
- 11 Miscellaneous
- Author Index
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