
General and Synthetic Methods
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Content
- General And Synthetic Methods
- Contents
- Chapter 1 Saturated and Unsaturated Hydrocarbons
- 1 Saturated Hydrocarbons
- 2 Olefinic Hydrocarbons
- 3 Conjugated 1,3-Dienes
- 4 Non-conjugated Dienes
- 5 Allenic Hydrocarbons
- 6 Acetylenic Hydrocarbons
- 7 Enynes and Diynes
- 8 Polyenes
- Chapter 2 Aldehydes and Ketones
- 1 Synthesis of Aldehydes and Ketones
- Oxidative Methods
- Oxidation of Alcohols
- Oxidation of Halides and Amines
- Oxidation of Alkynes, Alkenes, and Benzylic Hydrocarbons
- Reductive Methods
- Aldehydes from Acid Equivalents
- Ketones from Acid Equivalents
- Methods Involving Umpolung
- Other Methods
- 2 Synthesis of Functionalized Aldehydes and Ketones
- Unsaturated Aldehydes and Ketones
- a-Substituted Aldehydes and Ketones
- a-Hydroxy- or a-Alkoxy-substituted
- a-Phenylselenyl- or a-Phenylthio-substituted
- a-Halogeno-substituted
- a-Nitro- or a-Amino-substituted
- a-Trimethylsilyl-ketones
- Cyclic Ketones
- 3 Protection and Deprotection of Aldehydes and Ketones
- 4 Reactions of Aldehydes and Ketones
- Reactions of Enolates and Enolate Equivalents
- Aldol Reactions
- Conjugate Addition Reactions
- Chapter 3 Carboxylic Acids and Derivatives
- 1 Carboxylic Acids
- General Synthesis
- Diacids
- Hydroxy-acids
- Keto-acids
- Unsaturated Acids
- Decarboxylation
- Protection and Deprotection
- 2 Lactones
- ß-Lactones
- Butyrolactones
- Butenolides
- Tetronic Acids
- a-Methylenebutyrolactones
- Valerolactones
- 3 Macrolides
- 4 Esters
- Esterification
- General Synthesis
- Diesters
- Hydroxy-esters
- Keto-esters
- Unsaturated Esters
- Thioesters and Related Compounds
- 5 Carboxylic Acid Amides
- Synthesis
- Reactions
- Peptide Bond Formation
- 6 Amino-acids
- Synthesis
- Unsaturated a-Amino-acids
- Asymmetric Hydrogenation
- Protection and Deprotection
- Chapter 4 Alcohols, Halogeno-compounds, and Ethers
- 1 Alcohols
- Preparation
- Carbonyl Group Reduction
- Asymmetric Reductions
- Allylic Alcohols
- Other Unsaturated Alcohols
- Reactions
- Protection
- 1,2- and 1,3-Diols
- 2 Halogeno-compounds
- Preparation
- From Amines or Alcohols
- Other Methods
- Vinyl Halides
- Reaction
- Halogen Exchange-Phase Transfer Methods
- 3 Ethers
- Preparation
- Reactions
- 4 Thioethers
- Preparation
- 5 Macrocyclic 'Crown' Polyethers and Related Compounds
- Synthesis
- Complexation and Applications
- Chapter 5 Amines, Nitriles, and Other Nitrogen-containing Functional Groups
- 1 Amines
- Primary Amines
- Secondary Amines
- Tertiary Amines
- 2 Nitriles and Isocyanides
- 3 Nitro- and Nitroso-compounds
- 4 Hydroxylamines
- 5 Hydrazines
- 6 Azo-compounds
- 7 Imines
- 8 Enamines
- 9 Azides and Diazonium Compounds
- 10 Thiocyanates, Isothiocyanates, Isocyanates, Selenocyanates, and Isoselenocyanates
- 11 Nitrones
- Chapter 6 Organometallics in Synthesis
- Part I The Transition Elements
- 1 Hydrogenation
- 2 Oxidation
- 3 Isomerization
- 4 Carbon-Carbon Bond Formation
- Carbonylation
- Organo-copper Reagents
- Cyclization
- Alkylation using Olefins and Acetylenes
- 5 Synthesis of Nitrogen Heterocyclic Compounds
- Part II Main Group Elements
- 1 Introduction
- 2 Group I
- Regiospecific Lithiation
- Carbonyl Equivalents
- Nitro- and Cyano-stabilized Anions
- Miscellaneous
- 3 Group II
- Magnesium
- Cadmium and Mercury
- 4 Group III
- Boron
- Aluminium and Thallium
- 5 Group IV
- Silicon
- Silicon Species and C-C Bond Formation
- Silicon Reagents for Functional Group Modifications
- Germanium, Tin, and Lead
- 6 Group V
- Phosphorus
- Antimony and Bismuth
- 7 Group VI
- Sulphur
- Selenium
- Tellurium
- Chapter 7 Saturated Carbocyclic Ring Synthesis
- 1 Introduction
- 2 Three-membered Rings
- General Methods
- Natural Cyclopropanes
- 3 Four-membered Rings
- 4 Five-membered Rings
- General Methods
- Prostaglandins, Rethrolones, and Related Compounds
- Fused Five-membered Rings
- 5 Six-membered Rings
- Diels-Alder Cycloadditions
- Other Six-membered Ring Syntheses
- Anthracyclines and Aromatic Ring Annulation
- 6 Polyene Cyclization and Polycyclic Synthesis
- 7 Seven-membered Rings
- 8 Medium and Large Rings
- 9 Spiro-ring Annulations
- Chapter 8 Saturated Heterocyclic Ring Synthesis
- 1 Oxygen-containing Heterocycles
- Oxirans
- Oxetans
- Dihydrofurans and Tetrahydrofurans
- Pyrans
- Dioxetans
- Dioxolans and Dioxans
- Chromans
- Endoperoxides
- 2 Sulphur-containing Heterocycles
- Thiirans
- Thietans
- Dihydrothiophens and Tetrahydrothiophens
- Thiapyrans
- 3 Nitrogen-containing Heterocycles
- Aziridines
- Azetidines
- Pyrrolidines and Related Compounds
- Piperidines and Related Compounds
- Quinolines and Related Compounds
- Dihydroindoles
- Imidazolines
- Oxazolidines and Oxazines
- Pyrazolidines and Related Compounds
- Miscellaneous Nitrogen-containing Heterocycles
- 4 ß-Lactams, Penicillins, Cephalosporins, and Related Compounds
- Chapter 9 Strategy and Design in Synthesis
- 1 Introduction
- 2 General Papers
- 3 Applications of Computers
- 4 Selected Total and Partial Syntheses
- (+)- and (-)-Chrysanthemum Dicarboxylic Acid
- ß-Lactams
- Macrocyclic Lactones and Lactams
- Picrotoxinin
- Polyethers
- Prostaglandins
- 5 Functional Group Reactivity Umpolung
- 6 The Carbon Skeleton
- Dianions
- Intramolecular Reactions
- 7 Automated Organic Synthesis
- Reviews on General Synthetic Methods
- 1 Olefins
- 2 Aldehydes and Ketones
- 3 Esters and Lactones
- 4 Nitrogen-containing Functional Groups
- 5 Organometallics
- 6 Ring Synthesis
- 7 Heterocycles
- 8 Reduction
- 9 Asymmetric Synthesis
- 10 Carbohydrates
- 11 General
- 12 Miscellaneous
- Author Index
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