
Coarse-Grained Modeling of Biomolecules
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This book highlights the state-of-art in coarse-grained modeling of biomolecules, covering both fundamentals as well as various cutting edge applications. Coarse-graining of biomolecules is an area of rapid advances, with numerous new force fields having appeared recently and significant progress made in developing a systematic theory of coarse-graining. The contents start with first fundamental principles based on physics, then survey specific state-of-art coarse-grained force fields of proteins and nucleic acids, and provide examples of exciting biological problems that are at large scale, and hence, only amenable to coarse-grained modeling.
Introduces coarse-grained models of proteins and nucleic acids.
Showcases applications such as genome packaging in nuclei and understanding ribosome dynamics
Gives the physical foundations of coarse-graining
Demonstrates use of models for large-scale assemblies in modern studies
Garegin A. Papoian is the first Monroe Martin Associate Professor with appointments in the Department of Chemistry and Biochemistry and the Institute for Physical Science and Technology at the University of Maryland.
Reviews / Votes
"The chapters in this book survey the progress in simulating biomolecular dynamics.... The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific movement can bring forth its Picasso or Modigliani."-Peter G. Wolynes, Bullard-Welch Foundation Professor of Science, Rice University "The chapters in this book survey the progress in simulating biomolecular dynamics.... The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific movement can bring forth its Picasso or Modigliani."
-Peter G. Wolynes, Bullard-Welch Foundation Professor of Science, Rice University
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Person
He is recipient of numerous awards, including: Phillip and Ruth Hettleman Prize for Artistic and Scholarly Achievement 2010; ACS Hewlett-Packard Outstanding Junior Faculty Award 2010; National Science Foundation CAREER Award 2009; Camille Dreyfus Teacher-Scholar 2008; Beckman Young Investigator 2007; Camille and Henry Dreyfus New Faculty Award 2004; and National Institutes of Health Postdoctoral Fellowship 2001.
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