GTPases in Cellular Signalling
Published on 30. January 2019
236 pages
978-1-77361-768-8 (ISBN)
Description
GTPases in Cellular Signalling studies several aspects of cellularsignaling including an extensive overview of GTPases and relatedconcepts. It includes definitions of GTPASES in Signaling,GTPASES in Prokaryotes and latest trends in the cellular signaling.Provides the reader with insights into the development ofits understanding, so as to innovate technologies in this context.
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Content
- Cover
- Half Title Page
- Title Page
- Copyright Page
- Declaration
- About the Editors
- Table of Contents
- List of Contributors
- List of Abbreviations
- Preface
- Chapter 1 GTPases in Signalling: An Overview
- 1.1 Introduction
- 1.2 GTPases: A Glimpse
- 1.3 General Characteristics of Rho GTPases
- 1.4 Cellular Signaling
- 1.5 Cell Migration and GTPases
- 1.6 Cell Body Contraction And Tail Retraction
- 1.7 Signaling Pathways That Lie Upstream And Downstream in Rho GTPases
- 1.8 Activation of Rho GTPases By Adhesion
- 1.9 Crosstalk Between Rho GTPases
- 1.10 Altered Role In Cancer
- 1.11 Summarizing The Role of GTPases
- 1.12 Summary
- 1.13 References
- Chapter 2 GTPases in Prokaryotes
- 2.1 Rho GTPases in Bacteria
- 2.2 Bacterial Toxins Manipulate Rho-GTPase and Alter Cell Barriers
- 2.3 Inactivation of Toxins, Epithelial/Endothelial Barrier Permeability and Inflammatory Response by Rho GTPase
- 2.4 Bacterial Virulence Factors Towards Rho GTPases
- 2.5 Rho GTPases Are Targeted By Virulence Factors of Bacteria
- 2.6 GTPases in Archea
- 2.7 Summary
- 2.8 References
- Chapter 3 GTPases, Signalling and Roles in Organisms
- 3.1 In Plants
- 3.2 GTPases And Auxins
- 3.3 GTPases In Plant Stress
- 3.4 Rho Family Of GTPases: In Development Of Neurons
- 3.5 Summary
- 3.6 References
- Chapter 4 Rho GTPases: Signaling and Stem Cells
- 4.1 Introduction
- 4.2 Embryonic Stem Cells
- 4.3 Pluripotency Markers
- 4.4 Embryonic Stem Cell Culture
- 4.5 Embryonic Stem Cells And Rho Family Gtpases
- 4.6 Rho Signaling Pathways Of Embryonic Stem Cells
- 4.7 Rac Signaling In ES Cells
- 4.8 Cdc42 Signaling In ES Cells
- 4.9 Regulation Of Rho GTPases In Hematopoietic Stem Cells
- 4.10 HSCs Homing, Trafficking And Interaction
- 4.11 HSC Proliferation, Survival, And Self-Renewal
- 4.12 Summary
- 4.13 References
- Chapter 5 GTPases As Targets for Therapy
- 5.1 GTPases And Drug Targets
- 5.2 Rho GTPases and Alzheimer's Disease (AD)
- 5.3 Rho GTPases As Targets In Other Neuronal Diseases
- 5.4 Rho GTPases As Targets In Cardiovascular Diseases
- 5.5 Role Of Rho GTPases In Cancer
- 5.6 Summary
- 5.7 References
- Chapter 6 Rho GTPase Signalling in Cell Migration
- Abstract
- Introduction
- Lamellipodium-Driven Migration
- Migration In 3D And In Vivo: Different Types of Protrusions?
- Filopodia And Cell Migration
- Bleb-Driven Cell Migration
- Collective Cell Migration
- Migration Across Other Cells
- Conclusions And Future Directions
- Acknowledgments
- References
- Chapter 7 Are There Rab GTPases in Archaea?
- Abstract
- Introduction
- Results
- Discussion
- Materials And Methods
- Acknowledgments
- References
- Chapter 8 The GTPase-Activating Protein Rga1 Interacts with Rho3 GTPase and May Regulate Its Function in Polarized Growth in Budding Yeast
- Abstract
- Introduction
- Results
- Discussion
- Materials And Methods
- Acknowledgments
- Author Contributions
- References
- Chapter 9 Ran GTPase-Activating Protein 1 Is a Therapeutic Target in Diffuse Large B-Cell Lymphoma
- Abstract
- Introduction
- Materials And Methods
- Results
- Discussion
- Acknowledgments
- Author Contributions
- References
- Chapter 10 Rho GTPases as therapeutic targets in Alzheimer's disease
- Abstract
- Background
- Development Of Rho GTPase Pathway Modulators
- Challenges And Future Perspectives
- Conclusions
- Acknowledgements
- Authors' Contributions
- References
- Index
