Systems Biology: Simulation of Dynamic Network States
Simulation of Dynamic Network States
1st Edition
Published on 18. December 2011
978-1-139-11958-0 (ISBN)
Description
Biophysical models have been used in biology for decades, but they have been limited in scope and size. In this book, Bernhard O. Palsson shows how network reconstructions that are based on genomic and bibliomic data, and take the form of established stoichiometric matrices, can be converted into dynamic models using metabolomic and fluxomic data. The Mass Action Stoichiometric Simulation (MASS) procedure can be used for any cellular process for which data is available and allows a scalable step-by-step approach to the practical construction of network models. Specifically, it can treat integrated processes that need explicit accounting of small molecules and protein, which allows simulation at the molecular level. The material has been class-tested by the author at both the undergraduate and graduate level. All computations in the text are available online in MATLAB (R) and Mathematica (R) workbooks, allowing hands-on practice with the material.
More details
Language
English
Place of publication
Cambridge
United Kingdom
Publishing group
Cambridge University Press
Target group
Professional and scholarly
Illustrations
35 Halftones, unspecified; 91 Line drawings, unspecified
File size
7,86 MB
ISBN-13
978-1-139-11958-0 (9781139119580)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Bernhard O. Palsson
Systems Biology: Simulation of Dynamic Network States
Simulation of Dynamic Network States
Book
05/2011
Cambridge University Press
€102.40
Shipment within 15-20 days
Person
Bernhard O. Palsson is the Galletti Professor of Bioengineering and Adjunct Professor of Medicine at the University of California, San Diego.
Content
Preface; 1. Introduction; 2. Basic concepts; Part I. Simulation of Dynamic States: 3. Dynamic simulation: the basic procedure; 4. Chemical reactions; 5. Enzyme kinetics; 6. Open systems; Part II. Biological Characteristics: 7. Orders of magnitude; 8. Stoichiometric structure; 9. Regulation as elementary phenomena; Part III. Metabolism: 10. Glycolysis; 11. Coupling pathways; 12. Building networks; Part IV. Macromolecules: 13. Hemoglobin; 14. Regulated enzymes; 15. Epilogue; A. Nomenclature; B. Homework problems; References; Index.
