Protein Targeting with Small Molecules

Reviews / Votes

"The burgeoning are of chemical biology encompasses many subfields.While it undergoes constant changes in what it covers necessitatedby the rapid changes in both chemistry and biology, one centraltheme has remained constant--the use of small molecules as probesof myriad biological processes. The majority of bioactive smallmolecules of interest to chemical biologists manifest their uniqueand selective biological effects through binding to and interferingwith the function of proteins. As such, experimental tools andtechniques for detecting and deconvoluting the interactions betweensmall molecules and proteins are of great interest to contemporarychemical biologists. The book entitled "Protein Targetting withSmall Molecules" edited by Dr. Hiroyuki Osada thus fulfills animportant void in the field. In this book, different experimentalapproaches and techniques were reviewed by the frontlinepractitioners in the field. Both theoretical and practical aspectsof each general technique are thoughtfully covered, which werefurther illustrated by specific examples. It can serve multiplepurposes, as a text book for graduate level chemical biologyeducation and a reference book for those looking for new tools tostudy small-molecule protein and even small molecule-pathwayinteractions." --Dr. Jun Liu, Johns Hopkins University School ofMedicine "The book edited by Hiroyuki Osada, one of the foremost chemicalbiologists of the time, aims at covering this enormously wide fieldby twelve complementary reviews written by experts in theirindividual areas of research.... Taken together the book provides awidespread overview of numerous techniques, approaches and methodstypically applied in small molecule ligand design, synthesis,screening, target identification and validation as well asapplications in selected fields.... Thus, while reading thechapters, the reader is exposed to the variety of chemical,biophysical, biochemical and biological techniques typicallyapplied in small molecule based chemical biology research.... Assuch, I strongly recommend the book to researchers with advancedtraining in chemistry, biophysics, biochemistry and biology with adesire to branch out their research into neighboring disciplinesand ready to become chemical biologists." --Prof. Dr. Herbert Waldmann, Max Planck Institute ofMolecular Physiology