Molecular Mechanisms in the Control of Gene Expression
Published on 22. October 2013
668 pages
978-1-4832-7393-8 (ISBN)
Description
Molecular Mechanisms in the Control of Gene Expression documents the proceedings of the ICN-UCLA conference on Molecular Mechanisms in the Control of Gene Expression, organized through the Molecular Biology Institute of UCLA, held in Keystone, Colorado, 21-26 March 1976. The conference focused on three topics: the action of repressors on specific nucleotide sequences in DNA; how DNA and histones are intertwined in eucaryotic chromosomes; and in the development of new techniques that appear to lift genes from complex genomes. The volume contains 65 chapters organized into nine parts. The papers in Part I examine the organization of prokaryotic and eukaryotic chromosomes. Part II presents studies on the interaction of RNA a polymerase and regulatory molecules with defined DNA sites. Parts III and IV focus on RNA polymerases of eukaryotes and the regulation of transcription in eukaryotic systems, respectively. Part V contains papers dealing with nucleic acid sequences, transcription, and processing. Part VI covers cellular aspects in the study of gene expression. Part VII takes up cloning while Part VIII is devoted to genetic analysis through restriction mapping and molecular cloning. Finally, Part IX summarizes the recent progress reported at the conference and also indicates some of the limitations that can be placed upon interpretation of data.
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Content
PrefaceI. Organization of Prokaryotic and Eukaryotic Chromosomes 1. The Structure of Chromatin and Its Reconstruction 2. X-Ray Diffraction From Isolated Repeat Units of Chromatin 3. Nucleoprotein Core Particles in Chromatin Subunits: Existence of a Complex of Eight Histones and 140 Nucleotide Pairs of DNA 4. Histone 2A-2B-4 Interactions within Chromatin 5. The Site of Trimethylpsoralen Cross-Linking in Chromatin 6. The Isolation, Characterization and Suggested Structure of Euchromatic Segments from Mouse TLT Hepatoma Chromatin 7. Chromatin Assembly. Sites of Association of Newly Synthesized Chromatin Proteins on DNA 8. Autoradiographic Visualization and Sedimentation Properties of Unfolded Bacterial Nucleoid DNA 9. Thermoplasma Acidophilum: Studies on a Prokaryote That Contains a Histone-like Protein 10. Factors Which Control DNA Packaging May Influence the Control of TranscriptionII. Interaction of RNA Polymerase and Regulatory Molecules with Defined DNA Sites 11. Transcriptional and Translational (?) Control of the ¿ Repressor Gene (cl) 12. Regulation of Transcription Initiation and Termination in the Control of Expression of the Tryptophan Operon of E. coli 13. Positive Control of the Temporal Program of Bacteriophage SP01 Gene Expression by Phage and Host Specified Subunits of RNA Polymerase 14. DNA-Binding Specificity of a Positively Regulating RNA Polymerase 15. Characterization of the Promoter of the T4 tRNA Operon 16. Chemical Modification of Supercoiled DNA: Effect on the Rate of Transcription 17. The Interaction of Chemically Synthesized 21 Base Pair Lac Operator with the Lac Repressor 18. Synthesis of Lac and ¿ Operator DNA Sequences 19. Reconstitution of Operator DNA-Active Lactose Repressor from Subunits 20. Electron Microscopy of Glutamine Synthetase-DNA Interactions 21. Regulation of Transcription by Peptide AntibioticsIII. RNA Polymerases of Eukaryotes: Transcription and Specificity 22. Characteristics of an In Vitro System Which Transcribes Viral RNA from Chromatin 23. Selective Transcription of the 5S RNA Genes in Isolated Chromatin by RNA Polymerase III 24. Oocyte RNA Polymerase of Xenopus Laevis: In Vitro Transcription of Amplified Ribosomal DNA 25. Localization of RNA Polymerase on Drosophila Polytene Chromosomes by Indirect Immunofluorescence 26. Subclasses of RNA Polymerase in the Urchin Embryo 27. Multiple RNA Polymerases from Acanthamoeba castellanii: Lack of Alteration in Subunit Architecture and Levels during Encystment 28. DNA-Dependent RNA Polymerases from Higher Plants 29. Studies on the Inhibition of Transcription by the Hepatocarcinogen N-Hydroxy-2-AcetylaminofluoreneIV. Regulation of Transcription in Eukaryotic Systems 30. The Relationship between Chromatin Structure and Transcription 31. The Synthesis, Isolation, Amplification, and Transcription of the Ovalbumin Gene 32. Kinetics of Ovalbumin and Conalbumin mRNA Induction by Estrogen and Progesterone 33. DNA-Dependent RNA Polymerase I and II Activation by 17ß-Estradiol-Receptor Complex on Liver Chromatin from Immature Chicks 34. Effect of Estrogen on Gene Expression: Vitellogenin Synthesis May Be Regulated at the Level of Both Transcription and Translation 35. Selective Transcription of the Euglena gracilis Chloroplast Chromosome In Vitro 36. Products of Cell-Free RNA Synthesis Using Conditions Preventing Initiation and ProcessingV. Nucleic Acid Sequences, Transcription and Processing 37. Sequences of SV40 DNA 38. Complementary Sequences in Heterogeneous Nuclear RNA 39. Purification of Globin mRNA and Detection of Its Presumptive Precursor 40. The Complexity of Nuclear RNA and Messenger RNA m the Uninduced Friend Cell 41. A Comparison of the Sizes of Messenger RNAs Coding for Lysozyme (Gene 3.5) in T7-Infected RNase III+ and RNase III- Strains of Escherichia coli 42.
