Liver Transplantation
Description
The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care.
Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management.
Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy:
* A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models
* An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list
* A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list
* A discussion of care of the liver transplant recipient after the procedure in the short and long term
Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.
More details
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Persons
JAMES NEUBERGER, DM, FRCP is Consultant Physician in the Liver Unit, Birmingham, UK. A previous President of the British Association for the Study of the Liver, he has over 35 years of liver transplantation and disease experience and has edited five books on liver disease and liver transplantation and published extensively in liver disease and transplantation.
JAMES FERGUSON, MD, FRCPE is Consultant Hepatologist at the Queen Elizabeth Hospital in Birmingham, UK. He has extensive experience in managing patients with liver disease and in liver transplantation.
PHILIP N. NEWSOME, PHD, FRCPE is Professor of Experimental Hepatology and Honorary Consultant Hepatologist, Director of Research and Knowledge Transfer for the College of Medical & Dental Sciences and Director of the Centre for Liver and Gastrointestinal Research in the University of Birmingham, UK. Currently Secretary General of the European Association for the Study of the Liver, he continues to research in all aspects of liver disease and stem cell therapy.
MICHAEL RONAN LUCEY, MD, FRCPI is Chief of the Division of Gastroenterology and Hepatology at the University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. A past President of the American Society of Transplantation, he continues to publish widely in the field of liver disease and liver transplantation.
Content
List of Contributors x
Foreword to the Second Edition xx
Foreword to the First Edition xxi
Preface xxii
Abbreviations xxiii
Part 1 When to Refer a Patient for Liver Transplantation 1
1 Overview on Organ Donation and Liver Transplantation 3
Michael Ronan Lucey
2 Predicting Outcomes and Use and Abuse of Prognostic Models 11
Moira B. Hilscher and Patrick S. Kamath
Part 2 Selection, Assessment, and Management on the List 19
3 Assessment of the Potential Transplant Recipient 21
Michael L. Volk
4 Frailty and the Potential Liver Transplant Candidate 27
Matthew J. Armstrong and Jennifer C. Lai
5 Alcohol Use (excluding Alcohol-Related Liver Disease), Tobacco, Marijuana, and Illicit Drugs 33
John P. Rice
6 The Role of the Psychiatric Consultant in the Selection, Assessment, and Management of Liver Transplant Patients 39
Robert M. Weinrieb and Arpita Goswami-Banerjee
7 When Liver Transplant Patients Do Not Adhere to Therapeutic Plans 48
Kerry Webb and Rowena Jones
8 Liver Transplant Assessment for Young People: Addressing the Needs of Young People with Liver Disease 55
Marianne Samyn and Jemma Marie Day
9 Assessment and Management of the Patient with Hepatitis C 64
Emma L. Hathorn and David J. Mutimer
10 Management of Hepatitis B Virus Infection Pre Transplantation 68
Bruno Roche and Didier Samuel
11 Transplantation for the Management of Malignancy 74
Adiba I. Azad, Julie K. Heimbach, and Gregory J. Gores
12 Assessment and Management of the Liver Transplant Candidate with Acute-on-Chronic Liver Failure 82
Giovanni Perricone and Rajiv Jalan
13 Assessment and Management of the Transplant Candidate with Alcohol-Associated Liver Disease 96
Stéphanie Faure, Magdalena Meszaros, Lucy Meunier, Hélène Donnadieu-Rigole, and Georges-Philippe Pageaux
14 Non-alcoholic Fatty Liver Disease as an Indication for Liver Transplantation 104
Paul Horn and Philip N. Newsome
15 Consent 109
Christopher J.E. Watson
16 Prehabilitation and General Management 116
Matthew J. Armstrong and Felicity R. Williams
17 Removal of Patients from the Liver Transplant Waiting List 123
John O'Grady
18 Palliative Care and Liver Transplantation 126
Mina Rakoski and Puneeta Tandon
Part 3 Transplantation for Acute Liver Failure 135
19 Assessment of the Patient with Acute Liver Failure 137
Ashley Barnabas and John O'Grady
20 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation 143
Robert J. Fontana
Part 4 Donation and Allocation 153
21 Ethical and Legal Aspects of Organ Donation 155
Jessica Mellinger
22 Liver Allocation, Including Principles of Organ Allocation 161
Parita Patel and Michael Charlton
23 Living Donor Liver Transplant in Children 168
Adebowale A. Adeyemi, Elizabeth B. Rand, and Kim M. Olthoff
24 Living Liver Donation in Adults 180
Mohamed Rela and Ashwin Rammohan
25 Deceased Liver Donors: Standard and Expanded Criteria 190
Shareef Syed and Sandy Feng
26 Donor-Transmitted Disease 203
James Neuberger
27 Liver Donation and Preservation 209
Navneet Tiwari and Hynek Mergental
28 Liver Retrieval and Preservation 223
Carlo D.L. Ceresa, Brian R. Davidson, Peter J. Friend, and Rutger J. Ploeg
29 Alternatives to Whole Graft Liver Transplantation 236
Paolo Muiesan, Alessandro Parente, and Hector Vilca-Melendez
30 Surgical Aspects of Deceased Donor Transplantation 252
Amit Nair, K.V. Narayanan Menon, Cristiano Quintini, and Charles Miller
Part 5 Care of the Liver Transplant Recipient 265
31 Outcomes after Liver Transplantation 267
James Neuberger
32 Outpatient Follow-Up of Liver Transplant Recipients 276
Amardeep Khanna and James Ferguson
33 Medication Adherence 285
Maureen Whitsett and Josh Levitsky
34 Transitional Care 299
Fiona Thompson
35 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests 303
Joanna A. Leithead
36 The Immune System in Liver Transplantation: Rejection versus Tolerance 317
Palak J. Trivedi and Nick D. Jones
37 Immunosuppressive Medications: Liver Transplantation 334
Tim Mitchell and Gerry MacQuillan
38 Immunosuppression in Liver Transplantation 344
Nicholas Lim and John R. Lake
39 Patterns of Liver Allograft Rejection 353
Geoffrey W. McCaughan, Ken Liu, Avik Majumdar, Patrick Bertolino, David G. Bowen, and Simone I. Strasser
40 De Novo Autoimmune Hepatitis 360
James Neuberger
41 Managing Rejection 364
Neil Halliday and Douglas Thorburn
42 Withdrawal of Immunosuppression after Liver Transplantation 386
Luca Toti, Tommaso Maria Manzia, Francesca Blasi, and Giuseppe Tisone
43 Liver Transplant Pathology 393
Owen L. Cain and Stefan G. Hübscher
44 Care of the Liver Transplant Recipient: Management of Renal Function 403
Andres F. Carrion and Paul Martin
45 Managing Cardiovascular Risk in the Liver Transplant Recipient 409
Manhal Izzy and Kymberly D. Watt
46 Bone Disease in Liver Transplantation 418
John Ayuk
47 Diagnosis and Management of Recurrent Autoimmune Liver Disease 424
Fernanda Q. Onofrio, Nazia Selzner, and Gideon M. Hirschfield
48 NAFLD and NASH in the Patient after Liver Transplantation 438
Paul Horn and Philip N. Newsome
49 Recurrent Metabolic Diseases 445
James Neuberger
50 Treatment of Hepatitis C in the Transplant Setting 449
Jeffrey Kahn and Norah A. Terrault
51 Management of Hepatitis B Virus Infection Post Transplantation 458
Bruno Roche and Didier Samuel
52 Antimicrobial Prophylaxis Following Liver Transplantation 469
Michael J. Williams and Peter C. Hayes
53 Cytomegalovirus and the Liver Transplant Recipient 475
James Ferguson
54 Post-Liver Transplant Infections 481
Miruna David and Ahmed Elsharkawy
55 De Novo Malignancies after Liver Transplantation 493
Simone I. Strasser, Ken Liu, Avik Majumdar, and Geoffrey W. McCaughan
56 Post-Transplant Lymphoproliferative Disorders 500
Jose Ignacio Herrero
57 Quality of Life and Employment after Liver Transplantation 507
Santiago Tome, Esteban Otero, and Michael Ronan Lucey
58 Sexual Function, Fertility, and Pregnancy in Liver Disease and after Liver Transplantation 514
Patrizia Burra, Salvatore Stefano Sciarrone, and Patrizio Bo
59 Common Drug Interactions 519
Amanda Smith
60 Immunization and Liver Transplantation 525
Jessica Hause and Erin Spengler
Postscript 529
James Neuberger
Index 531
List of Contributors
Adebowale A. Adeyemi, MD
Medical Director, Liver Transplant Program
Nemours/Alfred I. duPont Hospital for Children
Wilmington, DE
USA
Matthew J. Armstrong, PhD, MRCP
Consultant in Liver and Transplant Medicine
Queen Elizabeth University Hospital
Honorary Lecturer
National Institute for Health Research Biomedical Research Centre
University of Birmingham
Birmingham, UK
John Ayuk, MD
Consultant Endocrinologist
Queen Elizabeth Hospital
Honorary Senior Lecturer
University of Birmingham
Birmingham
UK
Adiba I. Azad, MD, PhD
Gastroenterology Fellowship
Mayo Clinic
Rochester, MN
USA
Ashley Barnabas, MRCP
Clinical Research Fellow
Institute of Liver Studies
King's College Hospital
London
UK
Patrick Bertolino, MD
Associate Professor
Centenary Institute of Cancer Medicine and Cell Biology
AW Morrow Gastroenterology & Liver Centre
Royal Prince Alfred Hospital
University of Sydney
Camperdown
Australia
Francesca Blasi, MD
PhD student
Transplant and HepatobiliaryUnit
Department of Surgery
University of Rome Tor Vergata
Rome
Italy
Patrizio Bo, MD
Gynecologist
Obstetrics and Gynecology Unit
Cittadella Hospital
Cittadella
Padua
Italy
David G. Bowen, MD
Associate Professor of Medicine
Centenary Institute of Cancer Medicine and Cell Biology
AW Morrow Gastroenterology & Liver Centre
Australian National Liver Transplant Unit
Royal Prince Alfred Hospital
University of Sydney
Camperdown
Australia
Patrizia Burra, MD, PhD
Professor and Head of Multivisceral Transplant Unit
Department of Surgery, Oncology and Gastroenterology
Padua University Hospital
Padua
Italy
Owen L. Cain, MD, FRCPath
Consultant Histopathologist
Queen Elizabeth Hospital
Birmingham
UK
Andres F. Carrion, MD
Assistant Professor of Clinical Medicine
Division of Gastroenterology and Hepatology
University of Miami Miller School of Medicine
Miami, FL
USA
Carlo D.L. Ceresa, MB, ChB, MRCS, DPhil
MRC Clinical Research Fellow
Nuffield Department of Surgical Sciences, University of Oxford
Oxford University Hospitals NHS Foundation Trust
Oxford
UK
Michael Charlton, MD, FRCP
Professor of Medicine
Director, Center for Liver Diseases
University of Chicago Biological Sciences
Chicago, IL
USA
Miruna David, MRCP, FRCPath
Consultant Microbiologist
Department of Microbiology
Queen Elizabeth Hospital
Birmingham
UK
Brian R. Davidson, MB, ChB, MD, FRCS (Glasg), FRCSEng
Professor of Surgery
University College London
Consultant HPB and Liver Transplant Surgeon
Wellington Hospital and Royal Free Hospital NHS Foundation Trust
London
UK
Jemma Marie Day, DClinPsy
Clinical Psychologist
Department of Child Health
King's College Hospital Foundation NHS Trust
London
UK
Hélène Donnadieu-Rigole, MD, PhD
Consultant and Head of Department
Addiction Unit, CHU Saint Eloi
Montpellier University
Montpellier
France
Ahmed Elsharkawy, MD
Consultant Hepatologist
Liver Unit
Queen Elizabeth Hospital
Birmingham
UK
Stéphanie Faure, MD
Consultant
Hepatology and Liver Transplantation Unit, CHU Saint Eloi
Montpellier University
Montpellier
France
Sandy Feng, MD, PhD
Professor of Surgery
Director of the Abdominal Transplant Fellowship Program
Division of Transplantation, Department of Surgery
University of California-San Francisco
San Francisco, CA
USA
James Ferguson, MD
Consultant Physician and Honorary Reader
Liver Unit
Queen Elizabeth Hospital
Birmingham
UK
Robert J. Fontana, MD
Professor of Medicine and Medical Director of Liver Transplantation
University of Michigan Medical School
Ann Arbor, MI
USA
Peter J. Friend, MD, FRCS
Professor of Transplantation
Nuffield Department of Surgical Sciences, University of Oxford
Consultant HPB and Transplant Surgeon
Oxford University Hospitals NHS Foundation Trust
Oxford
UK
Gregory J. Gores, MD
Consultant
Division of Gastroenterology and Hepatology, Department of Internal Medicine
Executive Dean for Research
Mayo Foundation for Medical Education and Research
Mayo Clinic
Rochester, MN
USA
Arpita Goswami-Banerjee
Penn Transplant Institute
University of Pennsylvania Health Systems Perelman
School of Medicine
Philadelphia, PA
USA
Neil Halliday, MB BS, BSc
Speciality Registrar
Institute for Liver and Digestive Health
University College London
The Sheila Sherlock Liver Centre
Royal Free Hospital
London
UK
Emma L. Hathorn, MD
Fellow
Queen Elizabeth Hospital
Birmingham
UK
Jessica Hause
Fellow
Gastroenterology & Hepatology Faculty
University of Wisconsin
Madison, WI
USA
Peter C. Hayes, MD, PhD
Professor of Hepatology and Consultant Physician
Scottish Liver Transplant Unit
Royal Infirmary of Edinburgh
Edinburgh
UK
Julie K. Heimbach, MD
Professor of Surgery
Consultant and Chair
Division of Transplantation Surgery, Department of Surgery
Mayo Clinic
Rochester, MN
USA
Jose Ignacio Herrero, MD
Consultant, Liver Unit
Clinica Universidad de Navarra
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)
Instituto de Investigación Sanitaria de Navarra (IdiSNA)
Pamplona
Spain
Moira B. Hilscher, MD
Consultant Gastroenterologist
Division of Gastroenterology and Hepatology
Mayo Clinic
Rochester, MN
USA
Gideon M. Hirschfield, MRCP, PhD
Lily and Terry Horner Chair in Autoimmune Liver Disease Research
Toronto Centre for Liver Disease, Toronto General Hospital
University Health Network
Toronto
Canada
Paul Horn, MSc, MD
Research Fellow
Centre for Liver and Gastrointestinal Research
Birmingham
UK
Stefan G. Hübscher, MC, ChB, FRCPath
Leith Professor and Professor of Hepatic Pathology
Institute of Immunology and Immunotherapy
University of Birmingham
Consultant Histopathologist
Queen Elizabeth Hospital
Birmingham
UK
Manhal Izzy, MD
Assistant Professor of Medicine
Department of Gastroenterology and Hepatology
Vanderbilt University Medical Center
Nashville, TN
USA
Rajiv Jalan, MD, FRCP
Professor of Hepatology and Head, Liver
Failure Group
UCL Institute for Liver and Digestive Health
UCL Medical School, Royal
Free Hospital London
UK
Nick D. Jones, BSc, DPhil
Senior Lecturer
Institute of Immunology and Immunotherapy
University of Birmingham
Birmingham
UK
Rowena Jones, MD
Liver Unit, Queen Elizabeth Hospital
Birmingham
UK
Jeffrey Kahn, MD
Assistant Professor of Clinical Medicine
Division of Gastrointestinal and Liver Diseases
University of Southern California
Los Angeles, CA
USA
Patrick S. Kamath, MD
Consultant, Division of Gastroenterology and Hepatology
Department of Internal Medicine
Mayo Clinic
Rochester, MN
USA
Amardeep Khanna, MRCP
Specialist Registrar
Liver Unit
Queen Elizabeth Hospital
Birmingham
UK
Jennifer C. Lai, MD
Gastroenterologist
Division of Gastroenterology and Hepatology
Department of Medicine
University of California-San Francisco
San Francisco, CA
USA
John R. Lake, MD, BCh, BAO
Assistant Professor of Medicine
Division of Gastroenterology, Hepatology and Nutrition
University of Minnesota
Minneapolis, MN
USA
Joanna A. Leithead, MBChB, MRCP
Consultant Hepatologist
Addenbrookes Hospital
Cambridge
UK
Josh Levitsky, MD, MS
Professor of Medicine (Gastroenterology and Hepatology), Medical Education and Surgery (Organ Transplantation)
Northwestern Memorial Hospital
Chicago, IL, USA
Nicholas Lim, MD
Professor of Surgery and Medicine
Executive Medical Director for Solid Organ Transplantation
University of Minnesota Medical Center
Minneapolis, MN
USA
Ken Liu, MD
Senior Clinical Lecturer
Centenary Institute of Cancer Medicine and Cell Biology;
AW Morrow Gastroenterology and Liver Centre;
Australian National Liver Transplant Unit
Royal Prince Alfred Hospital
University of Sydney
Camperdown
Australia
Michael Ronan Lucey, MD
Professor of Medicine
Chief, Division of Gastroenterology and Hepatology
University of Wisconsin School of Medicine and Public Health
Madison, WI
USA
Gerry MacQuillan, PhD,...
