
Methods for Developing Spacecraft Water Exposure Guidelines
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Content
- Methods for Developing Spacecraft Water Exposure Guidelines
- Copyright
- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
- OTHER REPORTS OF THE COMMITTEE ON TOXICOLOGY
- Preface
- Contents
- Abbreviations
- Executive Summary
- WATER CONTAMINANT SOURCES
- RANKING CONTAMINANTS FOR RISK ASSESSMENT
- DATA FOR ESTABLISHING SWEGS
- RISK ASSESSMENT
- SPECIAL CONSIDERATIONS FOR NASA
- EXPOSURE GUIDELINES SET BY OTHER ORGANIZATIONS
- 1 Introduction
- WATER CONTAMINANTS
- APPROACH TO THE STUDY
- REFERENCES
- 2 Sources, Treatment, and Monitoring Of Spacecraft Water Contaminants
- OVERVIEW
- DESIGN DRIVERS
- ISS WATER-QUALITY STANDARDS
- SOURCES OF SPACECRAFT WATER CONTAMINATION
- HUMAN URINE
- Untreated Urine
- Chemical Treatment and Distillation By-Products
- HUMIDITY CONDENSATE
- Condensate Sample Results
- Water Recovery Test
- Lunar-Mars Life Support Test Project
- Space Shuttle
- Mir Humidity Condensate
- Environmental Contributors to Spacecraft Humidity Condensate
- Hardware Off-Gassing
- Animal Wastes
- Mechanical Leaks
- Microbial Metabolites
- Payload Chemicals
- Utility Chemicals
- WASH WATER AND OTHER WASTE STREAMS
- Hygiene Water
- Detergents
- Chemicals from Personal Hygiene Products
- CHeCS Wastes
- CHEMICALS FORMED IN THE WATER TREATMENT SYSTEM
- SYSTEM FAILURES AND INCOMPLETE PROCESSING OF INFLUENT
- CHEMICALS ADDED TO RETARD BACTERIAL GROWTH
- Iodine
- Silver
- REGENERATED WATER
- Inorganic Contaminants
- Shuttle Humidity Condensates
- Mir Humidity Condensates and Mir Reclaimed Water
- LMLSTP 60-d Product Water
- ORGANIC CONTAMINANTS
- Humidity Condensate in Mir
- LMLSTP 60-d Product Water
- Stage-10 WRT
- MONITORING WATER CONTAMINANTS
- SOURCE-WATER MONITORING
- In-Line Monitoring and Process Control
- Off-Line Monitoring
- SUMMARY
- REFERENCES
- 3 Sources and Types of Data for Establishing Spacecraft Water Exposure Guidelines
- CHEMICAL AND PHYSICAL CHARACTERISTICS OF A TOXICANT
- HUMAN STUDIES
- ANIMAL STUDIES
- IN VITRO TOXICITY STUDIES
- ADVANCES IN HEALTH EFFECTS ASSESSMENT
- NEUROBEHAVIORAL EFFECTS
- REPRODUCTIVE EFFECTS
- MUTAGENESIS
- MECHANISTIC STUDIES
- SUMMARY
- REFERENCES
- 4 Risk Assessment Methods for Determining Spacecraft Water Exposure Guidelines
- HISTORICAL PERSPECTIVE
- Risk Assessment for Noncarcinogenic Effects
- Risk Assessment for Carcinogenic Effects
- RECOMMENDED APPROACH TO RISK ASSESSMENT
- Exploiting Similarities of Historical Approaches
- Benchmark-Dose Approach to Setting SWEGs
- BMD CALCULATION
- Central Estimate Versus Confidence Limit
- Estimating BMDp for Various Toxic Effects
- EXPOSURE CONVERSION
- Target Tissue Dose
- Differences in Duration
- Species Conversions
- Different Routes
- UNCERTAINTY FACTORS
- Exposure Duration Uncertainty
- Interspecies Uncertainty
- Experimental Variation
- BMD10 to BMD01
- Environmental Effects
- Other Factors
- SETTING SWEGS
- Overall Uncertainty Factor
- Mixtures of Chemicals
- Multiple Toxic End Points
- Comparisons with Established Values
- ALTERNATIVE APPROACHES
- Integrated PBPK and BBDR Models
- Ordinal Regression
- Change-Point Dose-Response Models
- SUMMARY
- REFERENCES
- 5 Ranking Spacecraft Contaminants For Risk Assessment
- APPROACHES TO RISK PRIORITIZATION
- AD HOC APPROACH
- AD HOC APPROACH WITH FACTORS SPECIFIED
- FORMAL SYSTEM WITH PARAMETERS, WEIGHTS, AND INTERRELATIONSHIPS SPECIFIED
- FLEXIBILITY OF RISK PRIORITIZATION
- SUMMARY
- REFERENCES
- Appendix A Water Reclamation Systems on Mir And the International Space Station
- MIRWATER-RECOVERY SYSTEMS
- HUMIDITY CONDENSATE PROCESSING
- FILTER-REACTOR CATALYTIC OXIDATION
- URINE PROCESSING
- U.S. WATER-PROCESSING SYSTEM
- URINE PROCESSING
- COMBINED URINE AND WASTEWATER PROCESSING
- MULTIFILTRATION SUBSYSTEM
- VOLATILE REMOVAL ASSEMBLY
- REQUIREMENTS, PROPOSED LIMITS, AND MONITORING
- REFERENCES
- Appendix B Benchmark Dose Estimation
- DERIVING BENCHMARK DOSES FOR 1,4-DICHLOROBENZENE
- NONQUANTAL RESPONSE DATA
- HIGHLY VARIABLE QUANTAL DATA
- CARCINOGENIC EFFECTS
- DISCUSSION
- DERIVING BMDS FOR BOTULINUM TOXIN, VINYL CHLORIDE, AND AFLATOXIN
- REFERENCES
- Appendix C Biographical Information on the Subcommittee on Spacecraft Water Exposure Guidelines
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