Diamond-Based Materials for Biomedical Applications

Contributor contact details Woodhead Publishing Series in Biomaterials Part I: Introduction to diamond-based materials for medical applications Chapter 1: Introduction to medical applications of diamond particles and surfaces Abstract: 1.1 Introduction 1.2 Growth of synthetic diamond 1.3 Diamond-based medical devices 1.4 Functionalization of nanodiamond and nanocrystalline diamond 1.5 Drug delivery using nanodiamond 1.6 Imaging with nanodiamond 1.7 Conclusion 1.8 Acknowledgments Chapter 2: Functionalization of diamond surfaces for medical applications Abstract: 2.1 Introduction 2.2 Electrochemical reduction of aryldiazonium salts 2.3 Photochemical modification 2.4 Preparation of amine-terminated diamond surfaces 2.5 Preparation of oxygen-terminated diamond surfaces 2.6 Conclusion and future trends Chapter 3: Biotribology and biological behaviour of nanocrystalline diamond (NCD) coatings for medical applications Abstract: 3.1 Introduction to nanocrystalline diamond (NCD) 3.2 NCD-coated silicon nitride ceramics as new materials for joint replacement 3.3 Growth and characterization of NCD films deposited on Si3N4 substrates 3.4 Biotribology of NCD coatings 3.5 Biological behaviour of NCD-coated Si3N4 ceramics Chapter 4: Blood compatibility of diamond-like carbon (DLC) coatings Abstract: 4.1 Introduction 4.2 Diamond-like carbon (DLC) structure, properties and applications 4.3 Deposition techniques for DLC films 4.4 DLC blood compatibility 4.5 Modified DLC films 4.6 Biomedical applications of DLC coatings 4.7 Conclusion and future trends Part II: Biomedical applications of diamond-based materials Chapter 5: Nanostructured diamond coatings for orthopaedic applications Abstract: 5.1 Introduction 5.2 Ultra-hard carbon coatings 5.3 Wear measurements for ceramic-based orthopaedic implants 5.4 Mesenchymal stem cells derived from bone marrow and their interactions with nanostructured diamond surfaces 5.5 Macrophage cell interactions to diamond wear debris 5.6 In vivo evaluation of nanostructured diamond surfaces 5.7 Future trends 5.8 Acknowledgements Chapter 6: Ultrananocrystalline diamond (UNCD) films for ophthalmological applications Abstract: 6.1 Introduction 6.2 The use of ultrananocrystalline diamond (UNCD) films as coatings in the restoration of sight in people blinded by degenerated photoreceptors 6.3 The use of UNCD films in the treatment of glaucoma 6.4 Integrated magnet/superparamagnetic nanoparticles interacting system for new treatment of retina detachment 6.5 Conclusions 6.6 Acknowledgments Chapter 7: Ultrananocrystalline diamond (UNCD) for neural applications Abstract: 7.1 Introduction 7.2 Mechanism aspects of ultrananocrystalline diamond (UNCD)/neural cell interactions 7.3 Methods of guiding neurons 7.4 Neural and retinal prostheses Chapter 8: Nanodiamonds for drug delivery systems Abstract: 8.1 Introduction 8.2 Surface modification of diamond nanoparticles for drug delivery and targeting 8.3 Development of nanodiamond-based drug delivery for proteins 8.4 Development of nanodiamond-based drug delivery for genes 8.5 Development of nanodiamond-based drug delivery for low molecular weight therapeutic agents 8.6 Biocompatibility, biodistribution and biological fate of nanodiamonds 8.7 Conclusions Chapter 9: Diamond nucleation and seeding techniques for tissue regeneration Abstract: 9.1 Introduction 9.2 Diamond nucleation 9.3 Methods for diamond nucleation and seeding 9.4 Bias enhanced nucleation in hot filament chemical vapour deposition 9.5 Ultrasonic seeding 9.6 Seeding using a polymer composite 9.7 Spontaneous nucleation 9.8 Biological and tissue engineering applications Chapter 10: Diamond materials for microfluidic devices Abstract: 10.1 Introduction 10.2 Materials for the manufacture of microfluidic devices 10.3 Diamond microfluidic devices 10.4 Conclusions and future trends 10.5 Acknowledgments Index