Practical Transfusion Medicine
Description
Provides practical, evidence-based guidance for managing transfusion practice and patient care in patients who may require transfusion.
The rapid evolution of transfusion medicine, shaped by advances in science, technology, and global practice, demands an authoritative and up-to-date resource. Practical Transfusion Medicine, Seventh Edition, meets this need by offering a comprehensive and clinically grounded guide to the principles and practice of transfusion medicine. Building on the trusted foundations of previous editions, it balances depth of coverage with accessibility, making it an indispensable resource for trainee and practising haematologists, clinical and scientific staff working in transfusion services, and clinicians treating patients who may require transfusion.
This new edition reflects the considerable changes in the field since 2022, incorporating new sections on patient blood management, cellular and tissue therapy, and organ transplantation. A dedicated chapter on cardiorespiratory complications including transfusion-associated circulatory overload highlights their importance as a complication of transfusion, whilst the restructured clinical practice section offers a more focused approach to transfusion management across medical, surgical, and haematology patients. With contributions from leading international experts, the text provides evidence-based insights supported by numerous charts, tables, and algorithms.
Practical Transfusion Medicine, Seventh Edition:
- Integrates scientific, clinical, and regulatory perspectives with global context
- Provides detailed coverage of transfusion-associated complications and their management
- Features expanded sections on patient blood management, tissue therapy, and transplantation
- Balances comprehensive detail with clarity, offering more depth than handbooks yet more accessibility than reference tomes
- Addresses both acute clinical decision-making and long-term patient management
Practical Transfusion Medicine, Seventh Edition, is essential for postgraduate and specialist trainees in haematology preparing for examinations such as the FRCPath in the UK, as well as for trainees in the many specialties where transfusions are used. It is equally valuable as a reference tool for established clinicians treating patients requiring transfusion and for clinical and scientific staff working in transfusion services.
More details
Other editions
Additional editions
Persons
Michael F. Murphy is Professor of Transfusion Medicine at the University of Oxford, and Consultant Haematologist for NHS Blood & Transplant and the Department of Haematology, Oxford University Hospitals NHS Foundation Trust.
Nancy M. Dunbar is Transfusion Medicine Attending Physician, Medical Director of Blood Bank and Special Coagulation Lab, and Professor of Pathology and of Medicine at Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Erica M. Wood is Professor and Head of the Transfusion Research Unit in the School of Public Health at Monash University, and Consultant Haematologist at Monash Health in Melbourne, Australia.
Content
List of Contributors viii
Preface to the Seventh Edition xv
Part I Introduction 1
1 Past, Present and Future of Transfusion Medicine 1
Richard M. Kaufman
Part II Basic Principles of Immunohaematology and Transplantation 10
2 Essential Immunology for Transfusion Medicine 10
Connie M. Arthur and Sean R. Stowell
3 Red Blood Cell Antigens and Antibodies 19
Jennifer R. Hagman and Jill R. Storry
4 Platelet, Neutrophil and Leucocyte Antigens and Antibodies 31
Louise Helander and Caroline R. Alquist
Part III Overarching Principles of Good Practice in Transfusion Medicine 46
5 Evidence-Based Transfusion Medicine 46
Adam Irving, Khai L. Chai, Susan J. Brunskill, and Zoe K. McQuilten
6 Quality Management in Transfusion Medicine 59
Sarah L. Morley, Gustavo C. Duarte, and Fidelma Murphy
7 Donors and Blood Collection 70
Marc Germain and Pierre Tiberghien Copyrighted Material
8 Principles of Patient Blood Management 82
Allison Mo and Monica B. Pagano
9 The Role of Haemovigilance in Transfusion Safety 104
Barbee I. Whitaker, Katharine A. Downes, and Johanna C. Wiersum-Osselton
10 Emergency Blood Preparedness 115
Torunn O. Apelseth and Tom Scorer
Part IV Practice in Blood Centres and Hospitals 122
11 Blood Donation Testing and the Safety of the Blood Supply 122
Agbonbhaselena Omonua, Susan R. Brailsford, and Stephen Thomas
12 Production and Storage of Blood Components 132
Denese Marks and Susanne Marschner
13 Pre-transfusion Testing and the Selection of Products for Transfusion 148
Chris Hogan and Alison Davies
14 Hospital Oversight of Transfusion Safety and the Appropriate Use of Blood 159
Nicole Relke, Susan Nahirniak, and Andrew W. Shih
Part V Clinical Transfusion Practice 178
15 Inherited and Acquired Red Cell Disorders 178
Raisa Balbuena-Merle, Christopher A. Tormey, and David Raggay
16 Inherited and Acquired Platelet Disorders 190
Anand Padmanabhan and Dong Chen
17 Inherited and Acquired Disorders of Coagulation 204
Emmanuel J. Favaloro, Marian Rollins-Raval, and Rajiv Pruthi
18 Transfusion in Patients with Major Haemorrhage 222
Aaron Stansbury Hess
19 Elective Transfusions 233
Simon J. Stanworth and Akshay Shah
20 Obstetric Transfusion Medicine 243
Anna Parakh, Erin O'Reilly, and Helen Savoia
21 Neonatal, Infant and Paediatric Transfusion 255
Anne M. Kelly
22 Plasma Derivatives 267
Matea Vinkovic Vlah, Anja Mäkelburg, and Cynthia So-Osman
23 Therapeutic Apheresis 279
Andrew D. Johnson and Nicole D. Zantek
Contents vii
Part VI Complications of Transfusion 292
24 Approach to the Investigation and Management of a Patient with a Suspected Transfusion Reaction 292
HyoJeong Han and Meghan Delaney
25 Acute Haemolytic Transfusion Reactions 306
Courtney K. Hopkins and Rim Abdallah
26 Allergic and Anaphylactic Transfusion Reactions 318
Liz Marinaro and Ralph Vassallo
27 Respiratory Complications of Transfusion 326
Tom Latham, Rick Kapur, Alexander Vlaar, and Paula HB Bolton-Maggs
28 Complications of Transfusion: Bacterial Sepsis 339
Michel-Andrés García-Otálora, Sylvia Ighem-Chi, and Sandra Ramírez-Arcos
29 Delayed Complications of Blood Transfusion 351
France Pirenne and Mariane de Montalembert
30 Transfusion-Transmitted Infections - Pathogens of Concern 364
Brian Custer
31 Transfusion-Transmitted Infections - Interventions and Measuring Risk 373
Brian Custer
Part VII Cellular Therapy and Transplantation 382
32 Haematopoietic Cell Transplantation 382
Laura Connelly-Smith
33 Cellular Immunotherapy 397
Daniel North, Louis Peters, and Ronjon Chakraverty
34 Tissue Banking 409
Clint S. Schmidt, Kristen L. Rodriguez, Michael C. Deeds, and Eapen K. Jacob
Index 417
List of Contributors
Rim Abdallah
Corporate Medical Affairs, Vitalant
Scottsdale, AZ
USA
Caroline R. Alquist
Hoxworth Blood Center and University of Cincinnati
Cincinnati, OH
USA
Torunn O. Apelseth
Norwegian Centre for Blood Preparedness, Helse Bergen
Bergen
Norway
Department of Immunology and Transfusion Medicine
Haukeland University Hospital
Bergen
Norway
Faculty of Medicine
University of Bergen
Bergen
Norway
Connie M. Arthur
Brigham and Women's Hospital
Harvard Medical School
Boston, MA
USA
Raisa Balbuena-Merle
Department of Laboratory Medicine
Yale University School of Medicine
New Haven, CT
USA
Paula HB Bolton-Maggs
Faculty of Medicine, Biology and Health
University of Manchester
Manchester
UK
Susan R. Brailsford
Microbiology Services Clinical, NHS Blood and Transplant
Colindale
UK
Susan J. Brunskill
Systematic Review Initiative, NHS Blood and Transplant
Oxford
UK
Khai L. Chai
Transfusion Research Unit, School of Public Health and Preventive Medicine
Monash University
Melbourne
Australia
Department of Haematology
St Vincent's Hospital
Melbourne
Australia
Ronjon Chakraverty
Weatherall Institute of Molecular Medicine
University of Oxford
UK
Department of Haematology
Oxford University Hospitals NHS Foundation Trust
UK
Dong Chen
Department of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, MN
USA
Laura Connelly-Smith
Division of Haematology and Oncology
University of Washington and Fred Hutch Cancer Center
Seattle, WA
USA
Brian Custer
Epidemiology and Health Policy Research
Vitalant Research Institute
San Francisco, CA
USA
Department of Laboratory Medicine
University of California
San Francisco, CA
USA
Alison Davies
Department of Haematology and Transfusion
Austin Hospital
Melbourne
Australia
Mariane de Montalembert
Department of General Pediatrics and Pediatric Infectious Diseases
Sickle Cell Center, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris-Cité
Paris
France
Michael C. Deeds
Tissue Oversight Group, Mayo Clinic
Integrity and Compliance Office
Risk Department
Mayo Clinic
Rochester, MN
USA
Meghan Delaney
Division of Pathology and Laboratory Medicine
Childrens National Hospital
Washington, DC
USA
Pathology & Pediatrics
George Washington University School of Medicine and Health Sciences
Washington, DC
USA
Katharine A. Downes
Department of Pathology
Case Western Reserve University
Cleveland, OH
USA
Blood Banking and Transfusion Services
Department of Pathology
University Hospitals Cleveland Medical Center
Cleveland, OH
USA
Gustavo C. Duarte
New Zealand Blood Service
Auckland, New Zealand
Emmanuel J. Favaloro
Sydney Centres for Thrombosis and Haemostasis
Institute of Clinical Pathology and Medical Research (ICPMR)
Westmead, NSW
Australia
School of Dentistry and Medical Sciences
Faculty of Science and Health
Charles Sturt University
Wagga Wagga, NSW
Australia
School of Medical Sciences Faculty of Medicine and Health
University of Sydney
Westmead, NSW
Australia
Michel-Andrés García-Otálora
School of Medicine and Health Science
Public Health Research Group
Universidad del Rosario
Bogotá
Colombia
Marc Germain
Héma-Québec
Quebec City
Canada
Jennifer R. Hagman
Clinical Immunology and Transfusion Medicine, Skåne University Hospital
Lund University
Lund
Sweden
HyoJeong Han
Division of Haematology
Centre for Cancer and Blood Disorders Children's National Hospital
Washington, DC
USA
Department of Pediatrics
George Washington University School of Medicine and Health Sciences
Washington, DC
USA
Division of Pathology and Laboratory Medicine
Childrens National Hospital
Washington, DC
USA
Louise Helander
Department of Medicine
UC Health Hospital and University of Colorado Anschutz Medical Campus
Denver, CO
USA
Aaron Stansbury Hess
New Zealand Blood Service
Christchurch
New Zealand
Chris Hogan
Department of Haematology and Transfusion
Austin Hospital
Melbourne
Australia
Courtney K. Hopkins
Corporate Medical Affairs, Vitalant
Scottsdale, AZ
USA
Sylvia Ighem-Chi
Surveillance Discovery Laboratory, Medical Microbiology, Innovation, Canadian
Blood Services
Ottawa, ON
Canada
Department of Biochemistry, Microbiology and Immunology
University of Ottawa
Ottawa, ON
Canada
Adam Irving
Transfusion Research Unit, School of Public Health and Preventive Medicine
Monash University
Melbourne
Australia
Centre for Health Economics, Monash Business School
Monash University
Melbourne
Australia
Eapen K. Jacob
Division of Transfusion Medicine
Department of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, MN
USA
Andrew D. Johnson
Department of Laboratory Medicine and Pathology
University of Minnesota
Minneapolis, MN
USA
Rick Kapur
Research Group Leader, Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory Amsterdam UMC
University of Amsterdam
Amsterdam
The Netherlands
Richard M. Kaufman
Department of Pathology and Laboratory Medicine
Dartmouth Hitchcock Medical Centre
Lebanon, NH
USA
Anne M. Kelly
Paediatric Haemostasis and Thrombosis Department of Haematology
Great Ormond Street Hospital
London
UK
Great Ormond Street Hospital Haematology Laboratory
London
UK
Paediatric Transfusion and Components Clinical Expert; NHS Blood and Transplant
London
UK
Tom Latham
Consultant Haematologist NHS Blood and Transplant
Bristol
UK
Anja Mäkelburg
Department of Haematology
University Medical Center Groningen
Groningen
The Netherlands
Liz Marinaro
Vitalant
Scottsdale, AZ
USA
Denese Marks
Research and Development
Australian Red Cross Lifeblood
Sydney
Australia
Susanne Marschner
Vitalant Research Institute
Denver, CO
USA
Zoe K. McQuilten
Transfusion Research Unit, School of Public Health and Preventive Medicine
Monash University
Melbourne
Australia
Allison Mo
Transfusion Research Unit, Monash University, Monash Haematology and Austin Health
Melbourne
Australia
Sarah L. Morley
New Zealand Blood Service
Auckland
New Zealand
Fidelma Murphy
New Zealand Blood Service
Auckland
New Zealand
Susan Nahirniak
Department of Laboratory Medicine and Pathology
University of Alberta
Edmonton, AB
Canada
Transfusion and Transplantation Medicine
Alberta Precision Laboratories
Edmonton, AB
Canada
Daniel North
Weatherall Institute of Molecular Medicine
University of Oxford
UK
ACRF Translational Research Laboratory, Royal Melbourne Hospital
Australia
Erin O'Reilly
Department of Clinical Haematology
The Royal Children's Hospital
Melbourne, VIC, Australia
Agbonbhaselena Omonua
Technical and Scientific Development NHS Blood and Transplant
Colindale
UK
Anand Padmanabhan
Department of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, MN
USA
Monica B. Pagano
Transfusion Medicine, University of Washington
Seattle, WA
USA
Anna Parakh
Department of Clinical Haematology The Royal Women's Hospital
Melbourne, VIC
Australia
Louis Peters
Weatherall Institute of Molecular Medicine
University of Oxford
UK
Department of Haematology, Oxford University Hospitals NHS Foundation Trust
UK
France Pirenne
University Paris Est Creteil, Etablissement Français du Sang
France
Rajiv Pruthi
Department of Internal Medicine, Mayo Clinic
Rochester, MN
USA
David Raggay
Department of Laboratory Medicine
Yale University School of Medicine
New Haven, CT
USA
Sandra Ramírez-Arcos
Surveillance Discovery LaboratoryMedical Microbiology, InnovationCanadian Blood Services
Ottawa, ON
Canada
Department of Biochemistry, Microbiology and Immunology
University of...
