Practical Transfusion Medicine
Description
Practical Transfusion Medicine
Practical Transfusion Medicine, Sixth Edition
The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017.
The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text.
This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding.
This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.
About the Editors
Michael F. Murphy, MD, FRCP, FRCPath, FFPath, is Professor of Blood Transfusion Medicine at the University of Oxford, and Consultant Haematologist for NHS Blood and Transplant and the Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
David J. Roberts, MB, ChB, DPhil, FRCPath, is Professor of Haematology at the University of Oxford, Medical Director for Pathology for NHS Blood and Transplant and also works as a Consultant Haematologist in the Department of Haematology, John Radcliffe Hospital, Oxford, UK.
Mark H. Yazer, MD is Professor of Pathology at the University of Pittsburgh, an Adjunct Professor of Clinical Immunology at the University of Southern Denmark, Odense, Denmark, and a Visiting Professor of Pathology at Tel Aviv University. His research interest is in blood use in massive bleeding.
Nancy M. Dunbar, MD is Associate Professor of Pathology and Laboratory Medicine at the Geisel School of Medicine at Dartmouth and serves as the Medical Director of the Blood Bank at Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
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About the Editors
Michael F. Murphy, MD, FRCP, FRCPath, FFPath, is Professor of Blood Transfusion Medicine at the University of Oxford, and Consultant Haematologist for NHS Blood and Transplant and the Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
David J. Roberts, MB, ChB, DPhil, FRCPath, is Professor of Haematology at the University of Oxford, Medical Director for Pathology for NHS Blood and Transplant and also works as a Consultant Haematologist in the Department of Haematology, John Radcliffe Hospital, Oxford, UK.
Mark H. Yazer, MD is Professor of Pathology at the University of Pittsburgh, an Adjunct Professor of Clinical Immunology at the University of Southern Denmark, Odense, Denmark, and a Visiting Professor of Pathology at Tel Aviv University. His research interest is in blood use in massive bleeding.
Nancy M. Dunbar, MD is Associate Professor of Pathology and Laboratory Medicine at the Geisel School of Medicine at Dartmouth and serves as the Medical Director of the Blood Bank at Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Content
List of Contributors ix
Preface to the Sixth Edition xvi
1 Introduction: Two Centuries of Progress in Transfusion Medicine 1
Walter H. (Sunny) Dzik and Michael F. Murphy
Part I Basic Principles of Immunohaematology 11
2 Essential Immunology for Transfusion Medicine 11
Gregory A. Denomme
3 Human Blood Group Systems 21
Geoff Daniels and Sean Stowell
4 Human Leukocyte Antigens 33
H. Cliff Sullivan and Caroline R. Alquist
5 Platelet and Neutrophil Antigens 47
Brian R. Curtis
6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 64
Mark H. Yazer, Meghan Delaney and Gregory A. Denomme Copyrighted Material
Part II Complications of Transfusions 77
7 Investigation of Acute Transfusion Reactions 77
Heather Leary, Kathryn E. Webert and Nancy M. Heddle
8 Haemolytic Transfusion Reactions 91
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman
9 Febrile and Allergic Transfusion Reactions 108
Sarah K. Harm and Mark K. Fung
10 Transfusion- Associated Circulatory Overload 120
Robert B. Klanderman and Alexander P.J. Vlaar
11 Transfusion- Related Acute Lung Injury (TRALI) 130
Alexander P.J. Vlaar and Rick Kapur
12 Purported Adverse Effects of 'Old Blood' 145
Lirong Qu and Darrell J. Triulzi
13 Transfusion- Induced Immunomodulation 154
Neil Blumberg, Majed A. Refaai and Joanna M. Heal
14 Transfusion- Associated Graft- versus- Host Disease and Microchimerism 166
Alexandra Budhai, Richard O. Francis and Beth H. Shaz
15 Posttransfusion Purpura 181
Michael F. Murphy
16 Heparin- Induced Thrombocytopenia 187
Theodore E. Warkentin and Andreas Greinacher
17 Transfusion- Transmitted Infections 206
Steven J. Drews and Roger Y. Dodd
18 Bacterial Contamination 221
Sandra Ramírez- Arcos and Mindy Goldman
19 Emerging Infections and Transfusion Safety 229
Roger Y. Dodd
Part III Practice in Blood Centres and Hospitals 238
20 Regulatory Aspects of Blood Transfusion 238
Louis M. Katz, Peter Flanagan and William G. Murphy
21 The Role of Hemovigilance in Transfusion Safety 247
Katharine A. Downes and Barbee I. Whitaker
22 Donors and Blood Collection 257
Marc Germain and Pierre Tiberghien
23 Blood Donation Testing and the Safety of the Blood Supply 269
Mindy Goldman and Steven J. Drews
24 Production and Storage of Blood Components 278
Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo
25 Blood Transfusion in Hospitals 290
Zoe K. McQuilten, Erica M. Wood, Mark H. Yazer and Michael F. Murphy
26 Disaster Preparedness 313
Heidi Doughty, Fateha Chowdhury and Richard Rackham
27 Blood Transfusion in a Global Context 324
David J. Roberts, Imelda Bates, Stephen P. Field, Aggrey Dhabangi, Jean Pierre Allain and Meghan Delaney
Part IV Clinical Transfusion Practice 337
28 Inherited and Acquired Disorders of Haemostasis 337
Irina Chibisov, Jansen Seheult and Franklin Bontempo
29 Point- of- Care Haemostasis Testing 353
Katrina M. Morgan, Matthew D. Neal, Louis Alarcon and Christine M. Leeper
30 Transfusion in Bleeding Patients 365
Aaron S. Hess, Lynn G. Stansbury and John R. Hess
31 Transfusion in Non- Bleeding Medical and Surgical Patients 374
Killian Donovan, Akshay Shah, Stuart McKechnie and Simon J. Stanworth
32 Transfusion in Malignant Haematological Disease 385
Lise J. Estcourt and Michael F. Murphy
33 Transfusion in Benign Haematological Disease 399
Eric Salazar and Christopher A. Tormey
34 Transfusion in Patients with Haemoglobinopathies 409
Yvette C. Tanhehco and Patricia A. Shi
35 Transfusing Neonates and Infants 417
Marianne E. Yee and Cassandra D. Josephson
36 Immunodeficiency and Immunoglobulin Therapy 426
Siraj A. Misbah
Part V Patient Blood Management 441
37 Development of a Patient Blood Management Programme 441
Jonathan H. Waters
38 Perioperative Patient Blood Management 451
Martin Shao Foong Chong, Martin Rooms, Ravishankar Rao Baikady and Toby Richards
39 Restrictive Transfusion Practice and How to Implement It 465
Marie A. Hollenhorst and Lawrence Tim Goodnough
40 Using Data to Support Patient Blood Management 476
Nadia B. Hensley, Sandaruwani Abeysiri and Steven M. Frank
Part VI Cellular Therapy and Transplantation 489
41 Regulation and Accreditation in Cellular Therapy 489
Julia Wolf, Zbigniew (Ziggy) M. Szczepiorkowski and James Griffin
42 Stem Cell Collection and Therapeutic Apheresis 504
Khaled El- Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski
43 Haemopoietic Stem Cell Processing and Storage 519
Akash Gupta and Ronan Foley
44 Haematopoietic Cell Transplantation 531
Richard Salisbury, Yisu Gu, Rachael Hough and Robert D. Danby
45 CAR- T Cells and Recent Advances in Clinical Cellular Immunotherapy 543
Yisu Gu, Alex Rampotas, Connor Sweeney, David J. Roberts and Ronjon Chakraverty
46 Tissue Banking 554
Akila Chandrasekar, Richard Lomas and Paul Rooney
Part VII Development of the Evidence Base for Transfusion 561
47 Observational and Interventional Trials in Transfusion Medicine 561
Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert
48 Getting the Most Out of the Evidence for Transfusion Medicine and Lessons from the COVID- 19 Pandemic 576
Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Yulia Lin
49 A Primer on Biostatistics 590
Andrew W. Shih, Na Li, Celina Montemayor and Nancy M. Heddle
50 A Primer on Health Economics 609
Seema Kacker and Aaron A. R. Tobian
51 Scanning the Future of Transfusion Medicine 620
Jay E. Menitove, Paul M. Ness, Suzanne R. Thibodeaux and Edward L. Snyder
Index 632
List of Contributors
Sandaruwani Abeysiri
The Royal Marsden NHS Foundation Trust, London, UK
Louis Alarcon
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Jean Pierre Allain
NHS Blood and Transplant, Cambridge, UK
Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK
Caroline R. Alquist
Transplantation Immunology & Therapeutic Apheresis, Cincinnati, OH, USA
Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH, USA
Ravishankar Rao Baikady
The Royal Marsden NHS Foundation Trust, London, UK
Imelda Bates
Liverpool School of Tropical Medicine, Liverpool, UK
Neil Blumberg
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA
Blood Bank/Transfusion Service of Strong Memorial Hospital, Rochester, NY, USA
Franklin Bontempo
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Vitalant, Pittsburgh, PA, USA
Susan J. Brunskill
Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK
Alexandra Budhai
Memorial Sloan Kettering Cancer Center, New York, NY, USA
Rebecca Cardigan
NHS Blood and Transplant, Cambridge, UK
Ronjon Chakraverty
Department of Haematology, Churchill Hospital, Oxford, UK
BRC Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Akila Chandrasekar
NHS Blood and Transplant, Tissue and Eye Services, Liverpool, UK
Irina Chibisov
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Vitalant, Pittsburgh, PA, USA
Martin Shao Foong Chong
The Royal Marsden NHS Foundation Trust, London, UK
Fateha Chowdhury
NHS Blood and Transplant, London, UK
Imperial College Healthcare NHS Trust, Imperial College, London, UK
Brian R. Curtis
Platelet and Neutrophil Immunology Laboratory and Blood Research Institute, Versiti, Milwaukee, WI, USA
Robert D. Danby
Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Geoff Daniels
International Blood Group Reference Laboratory, NHS Blood and Transplant, Bristol, UK
Robertson D. Davenport
University of Michigan Health System, Ann Arbor, MI, USA
Meghan Delaney
Department of Pathology & Laboratory Medicine Division, Children's National Hospital, Washington, DC, USA
Department of Pathology & Pediatrics, The George Washington University, Washington, DC, USA
Gregory A. Denomme
Versiti Blood Research Institute and Diagnostic Laboratories, Milwaukee, WI, USA
Aggrey Dhabangi
Child Health and Development Centre, Makerere University College of Health Sciences, Kampala, Uganda
Roger Y. Dodd
American Red Cross, Jerome H. Holland Laboratory for the Biomedical Sciences, Rockville, MD, USA
Killian Donovan
Oxford University Clinical Academic Graduate School, John Radcliffe Hospital, Oxford, UK Adult Intensive Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Carolyn Dorée
Systematic Review Initiative, NHS Blood and Transplant, Oxford, UK
Heidi Doughty
NHS Blood and Transplant, Birmingham, UK
NIHR Surgical Reconstruction and Microbiology Research Centre, Institute of Translational Medicine, Birmingham, UK
Katharine A. Downes
University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA
Steven J. Drews
Microbiology, Canadian Blood Services, Edmonton, Alberta, Canada
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
Walter H. (Sunny) Dzik
Department of Pathology and Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Khaled El-Ghariani
NHS Blood and Transplant, Sheffield, UK
Sheffield Teaching Hospitals NHS Trust, Sheffield, UK
University of Sheffield, Sheffield, UK
Lise J. Estcourt
NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Dean Fergusson
Clinical Epidemiology Program,Ottawa Hospital Research Institute, Ottawa,Ontario, Canada
Stephen P. Field
Irish Blood Service, National Blood Centre, Dublin, Ireland
Peter Flanagan
New Zealand Blood Service, Wellington, New Zealand
Ronan Foley
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Richard O. Francis
Columbia University Medical Center, New York, NY, USA
Steven M. Frank
Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Mark K. Fung
Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA
Marc Germain
Héma-Québec, Quebec City, Quebec, Canada
Mindy Goldman
Canadian Blood Services, Ottawa, Ontario, Canada
University of Ottawa, Ottawa, Ontario, Canada
Lawrence Tim Goodnough
Departments of Pathology and Medicine, Stanford University, Stanford, CA, USA
Andreas Greinacher
Department of Immunology and Transfusion Medicine, Universitätsmedizin Greifswald, Greifswald, Germany
James Griffin
Therapeutics at NHS Blood and Transplant, Filton, Bristol, UK
Yisu Gu
Department of Haematology, Churchill Hospital, Oxford, UK
BRC Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK
Akash Gupta
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Sarah K. Harm
Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA
Joanna M. Heal
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA
Blood Bank/Transfusion Service of Strong Memorial Hospital, Rochester, NY, USA
Paul C. Hébert
Department of Medicine, Centre Hospitalier de L'Université de Montréal, Centre Recherche du Centre Hospitalier de Montréal, Montréal, Québec, Canada
Nancy M. Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Canadian Blood Services, Hamilton, Ontario, Canada
Nadia B. Hensley
Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Aaron S. Hess
Departments of Anesthesiology and Pathology and Laboratory Medicine, University of Wisconsin, Madision, WI, USA
John R. Hess
Departments of Laboratory Medicine and Pathology and Hematology, University of Washington, Seattle, WA, USA
Marie A. Hollenhorst
Departments of Pathology and Medicine, Stanford University, Stanford, CA, USA
Rachael Hough
University College London Hospital's NHS Foundation Trust, London, UK
Cassandra D. Josephson
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA, USA
Seema Kacker
The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA
Rick Kapur
Sanquin Research, Amsterdam, The Netherlands
Landsteiner Laboratory, Amsterdam UMC-AMC, Amsterdam, The Netherlands
Louis M. Katz
ImpactLife Blood services, Davenport, IA, USA
Infectious Diseases, Carver College of Medicine, University of Iowa Healthcare, Iowa City, IA, USA
Richard M. Kaufman
Brigham and Women's Hospital, Boston, MA, USA
Robert B. Klanderman
Department of Intensive Care and Department of Anesthesiology, Amsterdam UMC-AMC, University of Amsterdam, Amsterdam, The Netherlands
Heather Leary
Department of Haematology, Churchill Hospital, Oxford, UK
Christine M. Leeper
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Marissa Li
Cerus Corporation, Concord, CA, USA
Na Li
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Yulia Lin
Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Richard Lomas
NHS Blood and Transplant, Tissue and Eye...
