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Advances in Biology of Skin, Vol. I: Cutaneous Innervation focuses on the biology of skin, including the chemistry of the ground substance of the dermis to the biology of sebaceous glands. The selection first offers information on the pattern of cutaneous innervation of the human hand, foot, and breast and similarities in cutaneous nerve end-organs. Discussions focus on the methods of study, observations, histochemical reactions, and function of end-organs. The text then examines the autonomic innervation of the skin, cholinesterases in the cutaneous nerves of man, and the relation of nerve fiber size to modality of sensation. The manuscript ponders on the central paths of the afferent impulses from skin that arouse sensation and studies related to the mechanism of common sensibility, including materials and methods, anatomical and physiological observations, and interpretation of observations. The publication also takes a look at the structures and processes involved in the sensation of itch and the pathophysiology of itch sensation. The selection is a dependable reference for readers interested in the biology of skin.
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978-1-4832-8088-2 (9781483280882)
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List of ContributorsIntroductionChapter 1 The Pattern of Cutaneous Innervation of the Human Hand, Foot and Breast I. Introduction II. Methods of Study III. Observations A. The Pattern of Cutaneous Innervation of the Hand B. The Pattern of Cutaneous Innervation of the Human Foot C. The Pattern of Cutaneous Innervation of the Human Breast D. The Pattern of Innervation of the Deeper Tissues IV. Discussion V. Summary VI. ReferencesChapter II Similarities in Cutaneous Nerve End-Organs I. Introduction II. The Histochemical Reactions III. The Function of End-organs IV. Comment V. ReferencesChapter III The Autonomic Innervation of the Skin I. General Discussion II. ReferencesChapter IV Cholinesterases in the Cutaneous Nerves of Man I. Introduction II. Cholinesterase in Nerve Endings III. The Nerves around the Cutaneous Glands IV. The Nerves around Hair Follicles V. Comments VI. Summary VII. ReferencesChapter V The Relation of Nerve Fiber Size to Modality of Sensation I. Introduction II. ReferencesChapter VI The Central Paths of the Afferent Impulses from Skin Which Arouse Sensation I. Introduction A. The Separation of Sensory Paths into Central Tracts B. The Central Projections of the Sensory Systems C. The Problem of Pain and Temperature Reception D. Comparison of Somaesthetic and Visual Sensory Systems E. The Large-Fiber System in the Mammalian Cortex F. The Development of the Cortex as a Sensory Apparatus G. Convergence of the Sensory Paths II. ReferencesChapter VII Studies Related to the Mechanism of Common Sensibility I. Introduction II. Material and Methods A. Anatomical B. Physiological III. Anatomical Observations A. The Topography of the Ciliary Nerve Bundles B. Fiber Content of "Long" and "Short" Ciliary Nerve Bundles C. Number of Nerve Fibers Supplying the Cornea Counted at the Limbus D. Number of Nerve Fibers 6ì and larger in "Long" and "Mixed" Ciliary Nerve Bundles E. The Surface Areas of Cornea Served by the Various Types of Ciliary Nerve Bundles IV. Physiological Observations A. Activity Evoked in Whole "Long" Ciliary Nerve Bundles by the Application of Various Stimuli to the Cornea B. Activity Evoked in Teased Fractions of Fine "Long" Ciliary Nerve Bundles by Brushing and Heat Transfer C. Activity Evoked in Teased Fractions of Fine "Long" Ciliary Nerve Bundles by Electrical Stimulation of the Cornea D. Control Experiments E. The Distribution, in the Cornea, of the Terminals Served by Nerve Fibers of Different Diameters F. Anomalous Observations V. Interpretation of Observations VI. Discussion VII. Acknowledgments VIII. ReferencesChapter VIII Structures and Processes Involved in the Sensation of Itch I. Introduction II. Demonstration of Lowered Pain Threshold in Areas of Itching III. The Qualities of Cutaneous Pain and Itch A. Demonstration of Itching Sensation with a Burning Quality B. Demonstration of an Itching Sensation with Pricking Quality IV. Demonstration that Itch can be Abolished by Painful Pin Pricks within the Same Dermatome V. Demonstration that a Zone of Secondary Hyperalgesia Is "Anti-Pruritic" VI. Demonstration that Vasodilatation Is Accompanied by Lowered Pain Threshold and Spontaneous Itching VII. Demonstration of Heightened Vulnerability in Zones of Vasodilatation VIII. Demonstration of a Bradykinin-type Agent in Subcutaneous Perfusate Collected from Zones of Lowered Pain Threshold and Spontaneous Itching IX. Comment X. Demonstration that Activation of Sweat Glands Is Not a Required Step in Bradykinin Formation during Vasodilatation XI.