
Lipid Bilayers: Properties, Behavior and Interactions
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Content
- Intro
- Contents
- Preface
- Acknowledgments
- Chapter 1
- Fundamentals of Plasma, Nuclear and Mitochondrial Lipid Membranes
- Abstract
- 1.1. Plasma Membrane
- 1.1.1. Diversity of Lipids in Plasma Lipid Bilayers
- 1.1.2. Diversity of Proteins in Plasma Lipid Bilayers
- 1.2. Electrical State of Membrane
- 1.2.1. Membrane Potential
- 1.2.2. Resting Potential
- 1.2.3. Membrane as a Capacitor
- 1.3. Cell Signaling of Plasma Membranes
- 1.4. Nuclear Membrane
- 1.5. Cell Signaling of Nuclear Membrane
- 1.6. Mitochondrial Membrane
- 1.7. Mitochondrial Membrane Constituents and Their Roles in Signaling
- 1.7.1. Mitochondrial Membrane Lipids and Their Roles in Signaling
- 1.7.2. Mitochondrial Proteins and Membrane Based Signaling
- References
- Chapter 2
- Mechanical Stresses in the Lipid Bilayer of Erythrocyte Membranes
- Abstract
- 1. Introduction
- 2. Mechanical Stresses in the Lipid Bilayer of Erythrocyte Membranes
- 2.1. The Effect of Noradrenaline on the Surface Morphology of Erythrocyte Membranes
- 2.2. Investigation of Structural Transitions in Biomembranes by Fluorescence Methods
- 2.3. The Mechanism of the Hormone Effect on Structural Transitions in Biomembranes
- 2.4. The Features and Structure of Protein-Lipid Domains in Plasmatic Membranes
- 2.5. The Effect of Structural Transitions in Biomembrane on the Activity of Na+, K+-ATPases in Erythrocyte Membranes
- 2.6. The Effect of Mechanical Stresses on the Activity of Na+, K+-ATPases in Erythrocyte Membranes
- 2.7. Mechanical Stresses in Plasmatic Membranes
- 2.8. The Effect of Mechanical Stresses in Membrane on the Erythrocyte Shape and Surface Morphology
- Discussion
- Conclusion
- References
- Chapter 3
- The Role of the Lipid Bilayer in the Erythrocyte Membrane Structural Changes
- Abstract
- 1. Introduction
- 2. The Erythrocyte Membrane under Isotonic and Hypotonic Conditions
- 2.1. The Lipid Bilayer under Isotonic and Hypotonic Conditions
- 2.2. Band 3 Molecules under Isotonic and Hypotonic Conditions
- 2.3. The Spectrin-Actin Cortex under Isotonic and Hypotonic Conditions
- 3. Interactions of Band 3 Molecules with the Surrounding Lipid Bilayer
- 4. The Influence of the Bilayer Bending and the Attachment of Band 3 Molecules on Conformations of the Single Spectrin Filament
- 5. Bending Energy of the Lipid Bilayer - Thermodynamical Modeling Consideration at Mesoscopic Level
- 6. The Bilayer-Cortex Coupling - Rheological Modelling Consideration at Macroscopic Level
- 7. Results and Discussion
- Conclusion
- Acknowledgments
- References
- Chapter 4
- Microbial-Derived Bioactive Lipopeptides: Pore-Forming Metabolites in Lipid Bilayers
- Abstract
- Lipid Abbreviations
- 1. Introduction
- 1.1. Ecological Significance of Endophytic Associations between Plants and Microbia
- 1.2. The Lipid Bilayer: Action Target of Lipopeptide Compounds
- 2. Cyclic Lipopeptides from Bacillus: Surfactins, Iturins and Fengycins
- 2.1. Surfactin and Iturins
- 2.2. Fengycin
- 2.3. Daptomycin
- 2.4. Diversity of Bioactive Lipopeptides
- 3. Biophysics and Microbial Control
- Conclusion
- Acknowledgments
- References
- Chapter 5
- Colchicine Induced Ion Channel Formation into Membranes as a Mechanism behind Chemotherapy Drug Cytotoxicity of Cancer Cells
- Abstract
- 1. Introduction
- 2. Materials and Methods
- 2.1. Electrophysiology Experiments
- 2.2. MD Simulation
- 2.3. Colchicine Cytotoxicity assay on Breast Cancer Cell Lines
- 2.3.1. Materials
- 2.3.2. Colchicine Cytotoxicity Assay Protocol by Using MTT Assay Method
- 3. Results
- 3.1. Colchicine Kills Cancer Cells
- 4. Discussion
- 4.1. The Evidence of Chemotherapy Drug Induced Ion Pore Formation in Lipid Membranes
- 4.2. The Drug-Lipid Physical Interaction as a Possible Cause of Chemotherapy Drug Induced Pore Formation
- 4.3. Colchicine Shows Significant Cytotoxicity against Cancer Cell Lines
- Conclusion
- Acknowledgment
- Conflict of Interest
- References
- Appendix: Supporting Information, Figures
- Chapter 6
- Molecular Stability Analysis of Reverse Micelles Role in Breast Cancer Drug Delivery and It's Dynamics and Simulation Studies
- Abstract
- 1. Introduction
- 1.1. Breast Cancer
- 1.2. Types of Breast Cancer
- 1.2.1. Based on Tissues
- 1.2.2. Based on Invasiveness
- 1.2.3. Based on Hormones and Genes
- 1.3. Challenges in Treatment of Cancer
- 1.4. Lipid-Based Drug Delivery Systems
- 1.4.1. Emulsions
- 1.4.2. Microemulsion
- 1.4.3. Self-Emulsifying Drug Delivery System (Seeds)
- 1.4.4. Nanoemulsion
- 1.4.5. Pickering Emulsion
- 1.5. Vesicular System
- 1.6. Lipid Particulate System
- 1.6.1. Lipospheres
- 1.6.2. Lipid Drug Conjugates
- 1.7. Reverse Micelles Role in Drug Delivery
- 1.8. Dynamics and Simulation
- 2. Materials and Methods
- 2.1. Packing of Lipid with Drugs
- 2.2. Energy Minimization
- 2.3. Molecular Dynamics Simulation
- 3. Results and Discussion
- 3.1. Significance of Minimization
- 3.2. Thermal Stability of the Complexes
- 3.3. Energy Stability
- 3.4. Large Scale Dynamics of the Best Complex
- Conclusion
- References
- About the Editor
- Index
- Blank Page
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