
Introduction to Drug Carriers
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Content
- Intro
- Contents
- Preface
- Acknowledgments
- Chapter 1
- Cell Systems as Biological Drug Carriers
- Abstract
- 1. Introduction
- 2. Red Blood Cells as Drug Carriers
- 3. Stem Cells as Drug Carriers
- 4. Vesicles as Biological Drug Carriers
- References
- Chapter 2
- Vesicles as Drug Carriers
- Abstract
- 1. Introduction
- 1.1. Definitions and Subtypes Extracellular Vesicles
- 1.2. EV Structure and Composition
- 1.2.1. Lipid Content and Membrane Features
- 1.2.2. RNA
- 1.2.3. DNA
- 1.2.4. Protein
- 1.3. EV Function
- 2. Engineering Extracellular Vesicles as Nanotherapeutics
- 3. Applications of Vesicles in Cancer Treatment
- 3.1. Vesicles in Gene Therapy
- Conclusion
- References
- Chapter 3
- A Significant Role of Various Polymers Conjugated with Folic Acid into Micelles as a Drug Carrier in Receptor-Targeted Drug Delivery for Breast Cancer
- Abstract
- 1. Introduction
- 1.1. Nanoparticles
- 1.2. Polymers in Drug Delivery
- 1.3. Natural and Synthetic Polymers
- 1.4. Significance of Polymers
- 2. Materials and Methods
- 2.1. Polymer Selection and Construction
- 2.2. Simulation of Monomer
- 2.3. Packing of Drug with Polymers
- 2.4. Folic Acid Conjugation with Polymer
- 2.5. Polymer-Receptor Docking
- 3. Results and Discussion
- 3.1. Equilibration of Polymers
- 3.2. Critical Micelle Packing
- 3.3. Energy Minimization of the Complex
- 3.4. Electrostatic Stability
- 3.5. Temperature Profile
- 3.6. Folic Acid and Polymer Encapsulated Drug
- 3.7. Long scale Dynamics of PLA System
- 3.8. Radius of Gyration
- 3.9. Biological Significance of the Study
- 3.10. Polymer and Folic Acid Receptor Docked Complex
- Conclusion
- References
- Chapter 4
- Emerging Applications of Drug Delivery Systems in Odontogenic Infections - An Overview
- Abstract
- 1. Introduction
- 2. Anatomy of Teeth
- 3. Dental Caries
- 4. Stages of Dental Caries
- 4.1. Stage I - Formation of White Spots
- 4.2. Stage II - Enamel Decay
- 4.3. Stage III - Dentin Decay
- 4.4. Stage IV - Involvement of the Pulp
- 4.5. Stage V - Abscess Formation
- 5. Classification of Dental Caries Dye, B. (2010)
- 6. Strategies for Treatment
- 6.1. Mouth Wash
- 6.2. Varnish
- 6.3. Toothpaste
- 6.4. Dental Sealants
- 6.5. Biomimetic Approaches
- 6.6. Periodontitis
- 7. Classification of Periodontitis
- 8. Strategies for Treatment
- 8.1. Films
- 8.2. Fibers
- 8.3. Dendrimers
- 8.4. Liposomes
- 8.5. Hydrogels
- Conclusion
- References
- Chapter 5
- Nanotechnology of Cell Membrane and Drug Delivery
- Abstract
- 1. Nanoparticles as Drug Carriers
- 2. Membrane's Selective Transport and General Barrier Properties
- 3. Membrane Transports Nanoparticles. Perspective of Nanoparticle-Membrane Interactions
- 4. Certain Nanoparticles Disrupt Membranes
- 4.1. Effects of Nanoparticle Size and Structure on Membrane Disruption
- 4.2. Disruption of Membrane Depends on the Lipid Phase Properties
- 5. Nanoparticles May Avoid Interactions with Membranes
- 6. Membrane Transport of Nanoparticles through Ion Pores/Channels
- 6.1. Membrane Delivery of Nanoparticles through Lipid-Lined Ion Pores
- 6.2. Membrane Delivery of Nanoparticles through Non-Lipid-Lined Ion Pores
- 6.3. Theoretical Understanding of the Nanoparticle Diffusion through Ion Pores/Channels in Membranes
- 7. Nanotechnology of Lipid-Based Drug Delivery
- 7.1. Lipid Carriers to Improve Tuberculosis Treatment
- 7.2. Pharmaceutical Formulation for Effective Therapy Using Lipid Nanoparticles
- References
- Chapter 6
- Current Trends in Applications of Nanosponges: A Multifaceted Drug Carrier System
- Abstract
- 1. Introduction
- 2. Materials Used in Nanosponges Development
- 2.1. Polymers
- 2.2. Metals
- 2.3. Biomaterials
- 2.4. Crosslinkers
- 2.5. Solvents
- 3. Merits and Demerits of Nanosponges
- 3.1. Merits [9, 28, 29]
- 3.2. Demerits [29, 30]
- 4. Drug Release Mechanism from Nanosponges
- 5. Drug Loading Mechanism into Nanosponges
- 6. Biomedical Applications of Nanosponges
- 6.1. Photothermal Therapy
- 6.2. Theranostic Application
- 6.3. Targeted Drug Delivery
- 6.4. Large Molecules Delivery
- 6.5. Topical Drug Delivery
- 6.6. Ocular Drug Delivery
- 6.7. Oral Drug Delivery
- 6.8. Therapeutic Stability
- 6.9. Bio-Responsive Drug Delivery
- 6.10. Solubility Enhancement
- Conclusion
- References
- About the Editor
- Index
- Blank Page
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