Modifications of Nuclear DNA and its Regulatory Proteins
Academic Press
Published on 2. June 2011
502 pages
978-0-12-387686-7 (ISBN)
Description
DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.
- Discusses new discoveries, approaches, and ideas
- Contributions from leading scholars and industry experts
- Reference guide for researchers involved in molecular biology and related fields
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Other editions
Additional editions
Xiaodong Cheng | Robert M. Blumenthal
Modifications of Nuclear DNA and its Regulatory Proteins: Volume 101
Book
06/2011
Academic Press
€154.75
Shipment within 15-20 days
Persons
Content
1. Introduction - Epiphanies in EpigeneticsXiaodong Cheng and Robert M. Blumenthal
Section I. EVOLUTION OF DNA METHYLATION2. The natural history of eukaryotic DNA methylation systemsLakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind3. Evolution of histone methyltransferases and demethylasesL. Aravind4. DNA methylation in Drosophila - A critical evaluationVeiko Krauss and Gunter Reuter5. DNA Methylation in ZebrafishMary G Goll and Marnie E Halpern
Seciton II. MAMMALIAN DNA METHYLTRANSFERASES - STRUCTURE AND FUNCTION6. Dnmt1 - structure and functionZeljko M. Svedruzic7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferasesFrédéric Chédin
Seciton III. DNA METHYLATION AND DEMETHYLATION8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factorsJafar Sharif & Haruhiko Koseki9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cellsShannon R. Morey Kinney and Sriharsa Pradhan10. Mechanistic and functional links between histone methylation and DNA methylationTaiping Chen
Section IV. DNA METHYLATION IN MEDICINE11. RNA mediated silencing mechanisms in mammalian cellsAnton Wutz12. Biological functions of methyl-CpG binding proteinsPierre-Antoine Defossez and Irina Stancheva
Section V. DNA METHYLATION IN MEDICINE13. Diseases associated with imprintingJ.F. Wilkins and F. Úbeda14. DNA methylation changes in cancerMinoru Toyota and Eiichiro Yamamoto15. Epigenetic biomarkersJ. Tost16. Distribution of methylation at the single-nucleotide levelE.
