
Manual of STEMI Interventions
Description
Alles über E-Books | Antworten auf Fragen rund um E-Books, Kopierschutz und Dateiformate finden Sie in unserem Info- & Hilfebereich.
More details
Other editions
Additional editions


Person
Content
List of Contributors ix
Preface xiii
Part I Guidelines, Thrombolytic Therapy, Pharmacology 1
1 Compendium of STEMI Clinical Trials 3
Juanita Gonzalez Arango MD, Miguel Vega Arango MD, Estefania Calle Botero MD, Isaac Yepes Moreno MD, Maria Botero Urrea MD, Alicia Henao Velasquez MD, Daniel Rodriguez MD, Daniela Parra Dunoyer MD, Maria Teresa Bedoya Reina MD, Sameer Mehta MD
2 European Society of Cardiology and American College of Cardiology STEMI Guidelines 35
Estefania Oliveros MD, Sameer Mehta MD FACC, Alexandra Ferré MD, Tracy Zhang BS, Michael Schweitzer MD, Miguel Vega Arango MD, Juanita Gonzalez Arango MD, Maria Botero Urrea MD, Maria Teresa Bedoya Reina MD, Isaac Yepes MD
3 The Role of Thrombolytic Therapy in the Era of STEMI Interventions 55
Nestor Mercado MD, Theodore L. Schreiber MD, Cindy L. Grines MD
4 Anticoagulants in STEMI Interventions 65
Vincenzo Vizzi MD, Thomas W. Johnson BSc MBBS MD FRCP, Andreas Baumbach MD
5 New Oral and Intravenous Adenosine Diphosphate Blockers in STEMI Intervention 75
James J. Ferguson III MD
Part II The STEMI Procedure 105
6 The Role of Acute Circulatory Support in STEMI 107
Yousef Bader MD, Navin K. Kapur MD
7 Thrombus Management for STEMI Interventions 119
Sameer Mehta MD, Olga Reynbakh MD, Daniel Rodriguez MD, Tracy Zhang BS, Michael Schweitzer MD, Maria Teresa Bedoya Reina MD, Miguel Vega Arango MD, Juanita Gonzalez Arango MD, Maria Botero Urrea MD
8 Transradial Techniques to Improve STEMI Outcomes 145
Tejas Patel MD DM FACC FESC FSCAI, Sanjay Shah MD DM, Samir Pancholy MD FACC FSCAI
9 Management of Cardiogenic Shock 159
Holger Thiele MD, Suzanne de Waha MD
10 Present Role of Thrombectomy in STEMI Interventions 171
Francesco Giannini MD, Azeem Latib MD, Antonio Colombo MD
11 Choice of Stent in STEMI Interventions 187
Roopa Salwan MD
12 Illustrated STEMI Procedures I - Basic STEMI Skills 207
Sameer Mehta MD, Tracy Zhang BS, Michael Schweitzer MD, Alexandra Ferré MD, Daniella Nacad MD, Landy Luna Diaz MD, Alicia Henao Velasquez MD
13 Illustrated STEMI Procedures II - Basic STEMI Skills 223
Sameer Mehta MD, Tracy Zhang BS, Michael Schweitzer MD, Alexandra Ferré MD, Daniella Nacad MD, Landy Luna Diaz MD, Alicia Henao Velasquez MD
14 Illustrated STEMI Procedures III - Basic STEMI Skills 239
Sameer Mehta MD, Tracy Zhang BS, Michael Schweitzer MD, Alexandra Ferré MD, Daniella Nacad MD, Landy Luna Diaz MD, Alicia Henao Velasquez MD
15 Remote Ischemic Conditioning for Acute Myocardial Infarction 255
Hans Erik Bøtker MD PhD FACC FESC, Gerd Heusch MD FACC FESC FRCP
Part III The STEMI Process 273
16 Reducing Door-to-Balloon Times 275
Michel Le May MD, Joshua PY Loh MD
17 Pre-hospital Triage and Management 285
Ivan Rokos MD
18 Creating Networks for Optimal STEMI Management 299
David C. Lange MD, David M. Larson MD, David Hildebrandt RN, Timothy D. Henry MD
19 Pharmacoinvasive Management of STEMI 315
Neeraj Bhalla MD
Part IV Global STEMI Initiatives 325
20 Stent for Life: The European Perspective on STEMI Interventions 327
Sasko Kedev MD PhD FESC FACC
21 Urban Combined Pharmacoinvasive Management of STEMI Patients as Antidote to Traffic in Large Metropolitan Cities 333
David G. Iosseliani MD FACC FESC
22 Lessons from the Puerto Rico Infarction National Collaborative Experience Initiative 343
Orlando Rodríguez-Vilá MD MMS FACC FSCAI, Jose Escabi-Mendoza MD FACC, Fernando Lapetina-Irizarry MD FACC, Miguel A. Campos-Esteve MD FACC
23 The STEMI Care Program in China 357
Yan Zhang MD, Yong Huo MD
24 STEMI INDIA 363
Thomas Alexander MD, Ajit S Mullasari MD
25 The Role of Telemedicine in STEMI Interventions 371
Roberto Vieira Botelho MD PhD, Sameer Mehta MD FACC MBA, Julius Cezar Q. Ladeira DDS MSc, Francisco Fernandéz MBA, Márcio Sanches MD, Denis Fabiano de Souza RN, Wladimir Fernandes de Rezende MBA, Carlos Otávio Lara Pinheiro BSc
26 Innovative Telemedicine STEMI Protocols 379
Sameer Mehta MD FACC MBA, Roberto Vieira Botelho MD PhD, Freddy Bojanini MD, Juan Corral MD, Marco Perin MD, María Teresa Bedoya Reina MD, Juliana Giraldo MD, Laura Álvarez MD, Cindy Manotas MD, Sebastián Moreno MD, Sergio Reyes MD, María Botero Urrea MD
Part V Future Perspectives 395
27 STEMI Interventions, Beyond the Culprit Lesion 397
Neil Ruparelia PhD MRCP, Antonio Colombo MD, Azeem Latib MD
28 Promising Technologies for STEMI Interventions 409
Joshua PY Loh MD, HC Tan
Index 421
1
Compendium of STEMI Clinical Trials
Juanita Gonzalez Arango MD, Miguel Vega Arango MD, Estefania Calle Botero MD, Isaac Yepes Moreno MD, Maria Botero Urrea MD, Alicia Henao Velasquez MD, Daniel Rodriguez MD, Daniela Parra Dunoyer MD, Maria Teresa Bedoya Reina MD, Sameer Mehta MD
Introduction
As we constructed our fourth textbook of interventions for ST-elevation myocardial infarction (STEMI), the need for including a chapter on clinical trials was paramount. To provide a complete compendium of relevant STEMI guidelines and clinical trials, two distinct chapters have been created. We recognize that this information is easily obtained from searching the internet; however, we deemed it important to present in this book the most up-to-date guidelines and clinical trials. In this chapter, we have divided the trials into stents (Table 1.1), no-reflow (Table 1.2), thrombectomy (Table 1.3), percutaneous coronary interventions for non-culprit lesions (Table 1.4), and the role of left ventricular support devices (Table 1.5). In Chapter 2, we have separated out those guidelines from the American College of Cardiology and the European Society of Cardiology. These topics are discussed further in various chapters of the textbook. However, we firmly believe that a compendium of guidelines and clinical trials will provide a useful summary of these STEMI-related studies.
Table 1.1 Which stent is most desirable for STEMI interventions?
Study Title Hypothesis Cohort Principal Findings Conclusion COBALT: long-term clinical outcome of thin-strut CoCr stents in the DES era [1]. To assess characteristics and outcomes of patients treated with 2 different new-generation CoCr BMS, the MULTI-LINK VISION® and PRO-Kinetic Energy® stents. 1176 patients:MLV (n = 438); PRO-Kinetic (n = 738). TLR and TVR were lower in the MLV group. Death, MI, ARC and definite stent thrombosis were similar. The use of last-generation thin-strut BMS in selected patients is associated with acceptable clinical outcome, with similar clinical results for both the MLV and PRO-Kinetic stents. Comparison of newer-generation DES with BMS in patients with acute STEMI [2]. Efficacy and safety of newer-generation DES compared with BMS in patients with STEMI. 2665 STEMI patients: 1326 received a newer-generation DES (EES or biolimus A9 eluting stent) and 1329 received BMS. Newer-generation DES substantially reduced the risk of repeat TVR, target-vessel infarction, definite stent thrombosis compared with BMS at 1 year. Newer-generation DES improves safety and efficacy compared with BMS throughout 1st year. Meta-analysis of long-term outcomes for DES compared with BMS in PCI for STEMI [3]. Available literature examining the outcomes of DES and BMS in PPCI after > 3 years of follow-up. 8 RCTs and 5 observational studies.
5797 patients in whom 1st-generation DES (SES or PES) were compared with BMS control arms. Patients with DES had lower risk of TLR, TVR, and MACE. Incidence of stent thrombosis equal between groups. No difference in mortality or recurrent MI. Those receiving DES had lower mortality. DES use resulted in decreased repeat revascularization with no increase in stent thrombosis, mortality, or recurrent MI. Outcomes with various DES or BMS in patients with STEMI [4]. Efficacy (TVR) and safety (death, MI, and stent thrombosis) outcomes at the longest reported follow-up times with DES compared with BMS. 28 randomized clinical trials; 34,068 patients comparing any DES against each other or BMS. No increase in the risk of death, MI, or stent thrombosis with any DES compared with BMS. EES was associated with a statistically significant reduction in the rate of stent thrombosis when compared with SES, PES, and even BMS. DES versus BMS was associated with substantial decrease in the risk of TVR. EES had substantial reduction in the risk of stent thrombosis with no increase in very late stent thrombosis. Benefits of DES compared with BMS in STEMI: 4-year results of PES or SES vs. BMS in primary angioplasty (PASEO) randomized trial [5]. To evaluate the short and long-term benefits of SES and PES vs. BMS in patients undergoing primary angioplasty. 270 patients with STEMI were randomized to BMS (n = 90), PES (n = 90), or SES (n = 90). PES and SES were associated with significant reduction in TLR at 1year. No difference was observed in terms of death and reinfarction. SES and PES are safe and associated with significant benefits in terms of TLR up to 4 years of follow-up, compared with BMS. PPCI for AMI: long-term outcome after BMS and DES Implantation [6]. To investigate the long-term outcomes of unselected patients undergoing PPCI with BMS and DES. 1738 patients undergoing PPCI for a new lesion. 3 cohorts of BMS (n = 531), SES (n = 185) or PES (n = 1022). No differences in all-cause mortality or repeat revascularization between DES and BMS. SES was associated with lower rates of all-cause death, nonfatal MI, or TVR compared with PES. Very late stent thrombosis only occurred in the DES groups. DES are not associated with an increase in adverse events compared with BMS when used for PPCI, neither DES reduced repeat revascularizations. Safety and efficacy outcomes of first- and second-generation durable polymer DES and biodegradable polymer BES in clinical practice: comprehensive network meta-analysis [7]. To investigate the safety and efficacy of durable polymer DES and biodegradable polymer BES. 60 randomized controlled trials were compared, which involved 63,242 patients treated with DES. At 1year, there were no differences in mortality. Resolute and EZES, EES and SES were associated with reduced odds of MI compared with PES. Compared with EES, BP-BES were associated with increased odds of MI, while EZES and PES were associated with increased odds of ST. EES and EZES offering the highest safety profiles. The newer durable polymer EES and EZES and the BP-BES maintain the efficacy of SES. EES and EZES are the safest stents to date. EXAMINATION trial (EES Versus BMS in STEMI): 2-year results from a multicenter randomized controlled trial [8]. To evaluate the outcomes of the population included in the EXAMINATION trial. 1498 patients were randomized to receive EES (n = 751) or BMS (n = 747). Rate of TLR, definite or probable stent thrombosis was significantly lower in EES group than in BMS group. Both rates of TLR and stent thrombosis were reduced in recipients of EES. 2-year outcomes after first- or second-generation DES or BMS implantation in patients undergoing PCI. A pre-specified analysis from the PRODIGY study [9]. To assess device-specific outcomes with respect to the occurrence of MACE, after implantation of BMS, ZESS, PES, or EES in patients undergoing PCI. 2013 randomized patients undergoing CA in a 1:1:1:1 fashion to BMS, ZESS, PES, or EES implantation. MACE rate was lowest in EES, highest in BMS, and intermediate in PES and ZESS. The 2-year incidence of stent thrombosis in the EES group was similar to that in ZESS group, but lower compared with PES and BMS groups. MACE rate was lowest for EES, highest for BMS, and intermediate for PES and ZESS groups. EES outperformed BMS with safety endpoints and stent thrombosis. New DES for STEMI: A new paradigm for safety [10]. To compare the long-term safety of new-generation DES with early-generation DES and BMS for STEMI. 3464 STEMI patients were treated with BMS (n = 1187), early-generation DES (n = 1,525), or new-generation DES (n = 752). At 2 years, new-generation DES had lower mortality, similar reinfarction, and fewer stent thromboses compared with BMS; and similar mortality, similar reinfarction, and trends for fewer stent thromboses compared with early-generation DES. New-generation DES in STEMI patients have fewer stent thromboses compared with BMS and trends for fewer stent thromboses compared with early-generation DES. Safety and effectiveness of DES in patients with STEMI undergoing primary angioplasty [11]. To confirm the safety and effectiveness of DES in patients with STEMI. 370 patients (120 in DES group and 250 in BMS group) with STEMI treated with primary PCI. Patients were retrospectively followed for the occurrence of MACE. There was no difference in rate of stent thrombosis in the BMS group. Incidence of MACE was lower...
System requirements
File format: ePUB
Copy protection: Adobe-DRM (Digital Rights Management)
System requirements:
- Computer (Windows; MacOS X; Linux): Install the free reader Adobe Digital Editions prior to download (see eBook Help).
- Tablet/smartphone (Android; iOS): Install the free app Adobe Digital Editions or the app PocketBook before downloading (see eBook Help).
- E-reader: Bookeen, Kobo, Pocketbook, Sony, Tolino and many more (not Kindle).
The file format ePub works well for novels and non-fiction books – i.e., „flowing” text without complex layout. On an e-reader or smartphone, line and page breaks automatically adjust to fit the small displays.
This eBook uses Adobe-DRM, a „hard” copy protection. If the necessary requirements are not met, unfortunately you will not be able to open the eBook. You will therefore need to prepare your reading hardware before downloading.
Please note: We strongly recommend that you authorise using your personal Adobe ID after installation of any reading software.
For more information, see our ebook Help page.