Developmental and Fetal Origins of Differences in Monozygotic Twins
From Genetics to Environmental Factors
Published on 15. May 2020
386 pages
978-0-12-820307-1 (ISBN)
Description
Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.
- Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management
- Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis
- Features contributions from international experts in twin genetics and developmental biology
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Alexandra Matias | Isaac Blickstein
Developmental and Fetal Origins of Differences in Monozygotic Twins
From Genetics to Environmental Factors
Book
05/2020
Academic Press
€153.50
Shipment within 15-20 days
Content
1. Introduction
2. Biology of monozygotic twinning
3. Mechanisms of discordance in
monozygotic twins: why and when?
4. Monozygotic twins in history:
enlightenment by mythology and
ethnography
5. Genetics and epigenetics differences in
monozygotic twins: the vision of the
geneticist
6. Heterokaryotypic monozygotic twins
7. Differences in placentation in
monochorionic twin pregnancies
8. Differences in growth: selective
intrauterine growth restriction in
monochorionic twins
9. Hemoglobin differences at birth in
monochorionic twins
10. Differences in amniotic fluid in MZ
twins
11. Twin-reversed arterial perfusion
sequence: different identical twins
12. Major discordant anomalies in
monozygotic twins: management and
outcome
13. Congenital heart disease in
monozygotic twins
14. Spotting the differences in the
first trimester of pregnancy in MZ twins:
the issue of aneuploidies and TTTS
screening
15. Noninvasive prenatal screening in
twin pregnancies
16. A new way to look at multiples: the
power of image
17. Differences in monozygotic twins: the
implications of diet and intestinal
microbioma
18. Differences in development in
monozygotic twins
19. Monozygotic twins: a personal as
well as a criminal and jurisdictional
approach
20. Monozygotic twin differences in
perceived age
21. The environmental differences
between twins in utero and their
importance for downstream development: a
need for standardized monitoring in
obstetric research
22. Future perspectives
