
Current Topics in Membranes and Transport
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Content
- Front Cover
- Current Topics in Membranes and Transport
- Copyright Page
- Contents
- Preface
- Yale Membrane Transport Processes Volumes
- Part I: Description of Ion Transport Systems in Activated Cells
- Chapter 1. Mitogens and Ion Fluxes
- I . Introduction and Historical Perspective
- II. Ion Transport and pH Regulation in Cells
- III. Changes in Cell Membrane Voltage-Role in the Action of Growth Factors
- IV. Effect of Mitogens on Ion Fluxes and Intracellular pH
- V. Modulation of the Mitogenic Response by Protein Kinase C
- VI. Summary and Perspectives
- VII. Appendix: Measurement of Intracellular pH
- References
- Chapter 2. Na+-H+ and Na+-Ca2+ Exchange in Activated Cells
- I. Introduction
- II. Na+-Ca2+ Exchange
- III. Na+-H+ Exchange
- IV. Pharmacological Definition of the Na+-H+ and Na+-Ca2+ Exchange Systems
- V. Summary
- References
- Chapter 3. Chloride-Dependent Cation Cotransport and Cellular Differentiation: A Comparative Approach
- I. Introduction
- II. General Properties
- III. Properties in Blood Cells at Various Stages of Differentiation
- IV. Properties in Differentiated Epithelial Cells
- V. Nonepithelial Cells as Models for Cotransport during Differentiation
- VI . Conclusion
- Note Added in Proof
- References
- Part II: Triggers for Increased Transport during Activation
- Chapter 4. External Triggers of Ion Transport Systems: Fertilization, Growth, and Hormone Systems
- I. Introduction
- II. Ionic Responses to Fertilization
- III. Serum and Growth Factor Activation of Ionic Transport Systems in Cultured Cells and Lymphocytes
- IV. Hormonal Stimulation of Ion Transport and Hormone Secretion
- V. Concluding Remarks
- References
- Chapter 5. Early Stimulation of Na+-H+ Antiport, Na+-K+ Pump Activity, and Ca2+ Fluxes in Fibroblast Mitogenesis
- I. Introduction
- II. Ionic Responses Elicited by Growth Factors in Quiescent Cells
- III. Protein Kinases and Ion Fluxes
- IV. Calcium Fluxes
- V. Conclusions and Perspectives
- References
- Chapter 6. Volume-Sensitive Ion Fluxes in Amphiuma Red Blood Cells: General Principles Governing Na-H and K-H Exchange Transport and Cl-HCO3 Exchange Coupling
- I. Introduction: The Role of Alkali Metal-H Exchange in Cell Regulatory Processes
- II. Thermodynamic Principles of lon Transport: Electroneutral versus Conductive Alkali Metal Ion Fluxes
- III. Volume-Sensitive Ion Fluxes in Amphiuma Red Blood Cells
- IV. Ca2+-Dependent Alkali Metal Ion Flux in Amphiuma Red Blood Cells
- V. The Nature of Net Na Flux by Amphiuma Red Blood Cells in Hyperosmotic Media
- VI. Cl-HCO3 Exchange and Its Functional Relationship to Alkali Metal-H Exchange, Alkali Metal-Cl Cotransport, and Parallel Alkali Metal and H or Cl Conductance Pathways
- VII. Activation and Control of Alkali Metal-H Exchange in Amphiuma Red Blood Cells
- VIII. Summary
- References
- Part III: Consequences of the Alterations in Ion Transport Observed during Activation
- Chapter 7. Intracellular Ionic Changes and Cell Activation: Regulation of DNA, RNA, and Protein Synthesis
- I. Introduction
- II. DNA Synthesis
- III. RNA Synthesis
- IV. Protein Synthesis
- V. Posttranslational Events Influencing Intracellular Traffic and Cell Surface Expression of Proteins
- VI. Conclusions
- References
- Chapter 8. Energy Metabolism of Cellular Activation, Growth, and Transformation
- I. Introduction
- II. Control of Energy Metabolism in Adult Cells That Maintain a Relatively Constant Metabolic Rate
- III. Control of Energy Metabolism of Adult Cells That Can Be Rapidly Activated
- IV. Energy Metabolism of Cells in Culture
- V. Energy Metabolism of Malignant Cells
- References
- Index
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