Advances in Metabolic Disorders

ContributorsContents of Previous VolumesGeneral Introductory Speech Text Regulation of Cellular Growth I. Introduction II. How Do Growth-Regulating Factors Work? III. Cyclic AMP and Cell Growth IV. How Does Insulin Act to Lower Cyclic AMP Levels? V. How Might Cyclic AMP and Steroids Work to Control Cell Growth? VI. Cyclic GMP VII. Insulin Receptors, Cyclic AMP, and Cyclic GMP VIII. Malignant Transformation IX. Putting It All Together ReferencesSomatomedins Somatomedins I. Introduction II. Bioassay of Somatomedin III. Somatomedin in Man IV. Purification of Somatomedin V. Mechanism of Production of Somatomedin VI. Biological Action of Purified Somatomedins in Vitro VII. Conclusions and Discussion References Isolation and Chemistry of Human Somatomedins A and B I. Introduction II. Procedure for Isolation of Somatomedins III. Somatomedin A IV. Somatomedin B V. Discussion References The Measurement of Somatomedin A by Radioreceptor Assay I. Introduction II. Radioreceptor Assay Methodology III. Specificity of Somatomedin A Radioreceptor Assay IV. Somatomedin A in Human Serum V. Conclusions References Radioimmunoassay of Somatomedin B I. Introduction II. Radioimmunoassay Methodology III. Somatomedin B in Plasma IV. State of Somatomedin B in Plasma and Plasma Fractions V. Summary and Conclusions References The Response of Cultured Human Normal Glial Cells to Growth Factors I. Introduction II. The Glial Cell System III. The Glial Cell Bioassay of Growth-Promoting Substances IV. Somatomedins V. Fibroblast Growth Factor VI. Growth Factors Released by Cultured Cells VII. Platelets and Serum Factors VIII. Discussion IX. Summary Note Added in Proof References Somatomedin A and B: Demonstration of Two Different Somatomedinlike Components in Human Plasma I. Introduction II. 35SO4 Incorporation into Cell Cultures III. Stimulation of Sulfate Incorporation IV. Separation of Two Somatomedinlike Polypeptides from Human Plasma V. Summary References Preliminary Studies of Somatomedin In Vitro and In Vivo in Rats I. Introduction II. Materials and Methods III. Effect of Somatomedin in Vitro IV. Effect of Somatomedin in the Rat References Explorations of the Insulinlike and Growth-Promoting Properties of Somatomedin by Membrane Receptor Assays I. Introduction II. Studies of Insulinlike Properties of Somatomedin III. Comparisons between Insulinlike Activity (ILA) and Somatomedin Activity in Human Plasma Fractions IV. Studies with Purified Somatomedin C V. Measurement of Plasma Somatomedin Levels with the Specific Somatomedin C Receptor Assay VI. Conclusion VII. Summary References Somatomedin Generation by Perfused Livers I. Introduction II. Methods III. Results IV. Discussion References Somatomedin Levels in Human Beings I. Introduction II. Somatomedin Levels in Man III . Relation of Growth Hormone to Somatomedin References Further Observations on Plasma Somatomedin Activity in Children I. Introduction II. Plasma Somatomedin in a Nonselect Population of Children of Similar Age III. Further Observations on a Somatomedin Inhibitor in Malnutrition IV. Plasma Somatomedin Activity in Children with Emotional-Deprivation Short Stature V.