The Role of Chromosomes in Development
Published on 5. June 2014
302 pages
978-1-4832-6365-6 (ISBN)
Description
The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal proteins, DNA replication sequences in higher animals, and the implications of localized DNA synthesis in polytene chromosomes. Several papers describe chromosomal RNA, nuclear RNA fractions, genetic control, and the regulation of developmental pathways. One paper concerns the "bithorax" series that controls the development of certain body segments of the fly in a polarized and coordinated manner reminiscent of the genes in the operons of microorganisms. The bithorax genes evidently exploit and amplify a gradient arising from an anteroposterior gradient during mitotic division rates. The bithorax genes produces a whole set of new substances that repress certain systems of cellular differentiation, letting other systems to emerge and develop. Another paper investigates the hypothesis of diploid subnuclei as the architectural subunit of the ciliate macronucleus, as well as the hypothesis of "allelic repression" as the basis for certain examples of subnuclear differentiation. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.
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Content
Contributors and Presiding ChairmanDedicationThe Role of Chromosomes in Development Text ReferencesStructural Patterns and the Functional Organization of Chromosomes Replication Repository Function Variation Discussion and Summary ReferencesChromosomal Proteins Proteins and Chromosome Structure The Acidic Nuclear Proteins The Acidic Proteins and Gene Modulation The Histones and Gene Modulation Structure of the N-Proline Histone Mechanisms of Gene Modulation Functional State of the Genome Summary ReferencesBinding of Actinomycin as a Model for the Complex-Forming Capacity of DNA Text ReferencesDNA Replication Sequences in Higher Animals Introduction Materials and Methods The Relationship Between Heteropyknosis, Gene Inactivation, and DNA Replication The Terminal Stages of DNA Replication Late Replication and Metaphase Chromosome Morphology The Commencement of DNA Replication Quantitative Autoradiography of Chromosomes Discussion ReferencesLocalized DNA Synthesis in Polytene Chromosomes and Its Implications Text ReferencesChromosomal RNA and Other Nuclear RNA Fractions Chromosomal RNA Nucleolar RNA Nuclear Sap RNA Summary ReferencesGenetic and Functional Mosaicism in the Mouse Genetic Mosaicism Functional Mosaicism Summary ReferencesGenetic Repression of R Action in Maize Experimental Materials and Methods Paramutation of Rr in Rr Rst and Rrrr Heterozygotes Partial Reversion of Paramutant R Changes in Action of Rr and Rg Alleles from Stock Cultures in Heterozygotes with Each Other Acquisition of Paramutagenicity by Rr in Stippled Heterozygotes Association of the R Locus with Paramutation Continuous Variation in Paramutation Compound Nature of the Stippled Allele Progressive Paramutation in Successive Generations Occurrence of Paramutation in Somatic Cells Manifestation of Paramutation in Sporophytic Tissues The Origin and Geographic Distribution of Paramutable and Nonparamutable R Alleles R Action in Structurally Altered Chromosome 10 Paramutability of Rr When Carried by Chromosome K10 Level of R Action in Relation to Mode of Sexual Transmission Effects on Rr and Rst of High Energy Irradiation Is a Gene-Dependent Cytoplasmic Particle Associated with R Paramutation? Paramutation in Other Organisms Summary and Discussion ReferencesGenetic Control and Regulation of Developmental Pathways Introduction Genetic Methods for the Analysis of Development The Bithorax Pseudoallelic Series Developmental Effects of the Bithorax Mutants Gene Dosage Studies Somatic Mosaics Cis-Trans Effects The Trans-Vection Effect Discussion Summary ReferencesMacronuclear Differentiation and Subnuclear Assortment in Ciliates Morphological Nuclear Differentiation Caryonidal Distribution: Mating Type Differentiation in Syngen 1, Paramecium aurelia Subnuclear Assortment: Mating Type Differentiation in Syngen 1, Tetrahymena pyriformis Subnuclear Assortment: Allelic Repression or Heterozygote Resolution? Conclusion ReferencesAuthor IndexSubject Index
