The Role of Chromosomes in Development
Published on 2. December 2012
302 pages
978-0-323-15685-1 (ISBN)
Description
The Role of Chromosomes in Development is a collection of papers presented at the 23rd Symposium of the Society for the Study of Development and Growth, held at Amherst, Massachusetts in June 1964. Contributors explore the role of chromosomes in development, highlighting important processes such as the diversification and specialization of cells; the regulation of gene function by the physical state of the chromosome; the functional organization of chromosomes; DNA replication and synthesis; and macronuclear differentiation and subnuclear assortment. This volume is organized into 11 chapters and begins with an overview of chromosome structure and function and the mechanisms underlying the role of the chromosome in embryonic development. This book then discusses the chromosomal DNA replication, the mechanisms of gene modulation, the binding of actinomycin to DNA, and the cytological aspects of DNA replication in higher animals. The next chapters explain localized DNA synthesis in polytene chromosomes; chromosomal RNA and other nuclear RNA fractions; and experimental work probing both genetic and functional mosaicism in the mouse, as well as genetic repression of the R locus in maize. The book also considers how developmental pathways are controlled by genetic mechanisms, and then concludes with a chapter on nuclear differentiation in ciliates and on the phenomenon of subnuclear assortment. This book will be of interest to developmental biologists and embryologists.
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Content
Contributors and Presiding ChairmenDedicationThe Role of Chromosomes in Development Text ReferencesStructural Patterns and the Functional Organization of Chromosomes Replication Repository Function Variation Discussion and Summary ReferencesChromosomal Proteins Proteins and Chromosome Structure The Acidic Nuclear Proteins The Acidic Proteins and Gene Modulation The Histones and Gene Modulation Structure of the N-Proline Histone Mechanisms of Gene Modulation Functional State of the Genome Summary ReferencesBinding of Actinomycin as a Model for the Complex-Forming Capacity of DNA Text ReferencesDNA Replication Sequences in Higher Animals Introduction Materials and Methods The Relationship between Heteropyknosis, Gene Inactivation, and DNA Replication The Terminal Stages of DNA Replication Late Replication and Metaphase Chromosome Morphology The Commencement of DNA Replication Quantitative Autoradiography of Chromosomes Discussion ReferencesLocalized DNA Synthesis in Polytene Chromosomes and Its Implications Text ReferencesChromosomal RNA and Other Nuclear RNA Fractions Chromosomal RNA Nucleolar RNA Nuclear Sap RNA Summary ReferencesGenetic and Functional Mosaicism in the Mouse Genetic Mosaicism Functional Mosaicism Summary ReferencesGenetic Repression of R Action in Maize Experimental Materials and Methods Paramutation of Rr in RrRst and Rrrr Heterozygotes Partial Reversion of Paramutant R Changes in Action of Rr and R9 Alleles from Stock Cultures in Heterozygotes with Each Other Acquisition of Paramutagenicity by Rr in Stippled Hétérozygotes Association of the R Locus with Paramutation Continuous Variation in Paramutation Compound Nature of the Stippled Allele Progressive Paramutation in Successive Generations Occurrence of Paramutation in Somatic Cells Manifestation of Paramutation in Sporophytic Tissues The Origin and Geographic Distribution of Paramutable and Nonparamutable R Alleles R Action in Structurally Altered Chromosome 10 Paramutability of Rr When Carried by Chromosome K10 Level of R Action in Relation to Mode of Sexual Transmission Effects on Rr and Rst of High Energy Irradiation Is a Gene-Dependent Cytoplasmic Particle Associated with R Paramutation? Paramutation in Other Organisms Summary and Discussion ReferencesGenetic Control and Regulation of Developmental Pathways Introduction Genetic Methods for the Analysis of Development The Bithorax Pseudoallelic Series Developmental Effects of the Bithorax Mutants Gene Dosage Studies Somatic Mosaics Cis-Trans Effects The Trans-Vection Effect Discussion Summary ReferencesMacronuclear Differentiation and Subnuclear Assortment in Ciliates Morphological Nuclear Differentiation Caryonidal Distribution: Mating Type Differentiation in Syngen 1, Paramecium aurelia Subnuclear Assortment: Mating Type Differentiation in Syngen 1, Tetrahymena pyriformis Subnuclear Assortment: Allelic Repression or Hétérozygote Resolution? Conclusion ReferencesAuthor IndexSubject Index
