Major Problems in Developmental Biology

Contributors and Presiding ChairmanThe Growth and Development of Developmental Biology Introduction The State of Embryology in 1938 and 1939 The State of Some Nonembryological Areas of Biology from 1938 to 1940 Some Society Earlies Organizers of the Symposia and Officers of the Society from 1939 to 1965 References The Keys to Change: Factors Regulating Differentiation Introduction The Constancy Hypothesis Differential Replication of DNA Differential Release of Information: Puffing and Compacted Regions DNA and RNA Synthesis during Oogenesis and Early Development The Virus Susceptibility of Differentiating Cells DNA Replication and Antibody Formation Factors Regulating Differentiation Conspectus References Dynamics of Determination Text References Fields and Gradients The Basic Terminology The Nature of Fields The Temporal Characteristics of Fields The Causal Complexity of the Field Abstractions from the Total Field Concept Summary References Morphogenetic Cell Movements Introduction Cell Movements in Culture Mechanism of Morphogenetic Movements Epilogue References The Formation of Patterns in Development Introduction Patterns in Bird Feathers Pigment Patterns in Amphibians Bristle Patterns in Insects Stomatal Patterns in Plant Leaves, with a Note on Drosophila Ocelli and Turing's Model Scales, Color Patterns, and Hinges of Butterfly Wings Appendix Conclusions Summary References Protein Structure in Relation to Cell Dynamics and Differentiation Three-Dimensional Structure of Proteins Protein Flexibility in Relation to Enzyme Action Protein Flexibility in Relation to Activation Processes Protein Flexibility in Relation to Inhibition Processes A Mechanism for Protein Conformational Changes Cooperative Effects Protein Flexibility in Relation to Other Biological Processes Protein Flexibility in the Control of Protein Synthesis Amplification of Biological Changes Suggestions for Mechanisms of Differentiation References Intercellular Regulation in Plants Pharmacological Aspects Physiological Aspects Comparative Biochemical Aspects Molecular Biological Aspects A Look at the Past and Present Intercellular Regulation in Plants: Short-Distance Effects References Cell Death in Morphogenesis Introduction Integration of Patterns of Growth and Death in Shaping the Vertebrate Limb Control of the Death Program Execution of the Death Sentence General Conclusions References Fact and Theory about the Cell Surface in Carcinogenesis Contact Inhibition Studies of Cell Membranes The Growth of Cells in Tissue Culture Demonstration of "Conditioning Factor" Conditioning of Medium by Rous Sarcoma Cells General Discussion Summary References Starting Points for Research in the Ontogeny of Behavior Electrical Activity of Neurons during Maturation Effects of Growth Factors and Hormones on Neuronal Maturation Effects of Function on Neuronal Maturation Are Neuronal Connections Predetermined during Development? Formation of Connections between the Retina and Brain Specification of Retinal Ganglion Cells References Author Index Subject Index