
Bladder Cancer
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Content
List of contributors vii
Preface xii
Acknowledgments xiii
Part I: Diagnosis and treatment of non-muscle-invasive bladder cancer
1 Pathology 3
Hikmat Al-Ahmadie and Donna E. Hansel
2 Risk stratification of high?]grade Ta CIS and T1 urothelial carcinoma of the bladder 18
Tobias Klatte, Fred Witjes, Gary Steinberg, and Shahrokh F. Shariat
3 Utility of urine biomarkers 26
Derya Tilki and Alexandre R. Zlotta
4 Novel endoscopic techniques for the detection of bladder cancer 39
Ayman Soubra, Joseph C. Liao, and Badrinath Konety
5 Transurethral resection of bladder tumors 51
Jen-Jane Liu and Mark P. Schoenberg
6 Intravesical chemotherapy 64
Levent N. Türkeri, M.Guillaume Wientjes, and Jessie L.S. Au
7 Intravesical immunotherapy 76
Nilay M. Gandhi, Laura A. Bertrand, Donald L. Lamm, and Michael A. O'Donnell
8 HGT1 bladder cancer: Diagnosis and treatment 89
J.M. Gaya, J. Palou, and Edward M. Messing
9 What to do when bacillus Calmette-Guérin fails 98
Massimiliano Spaliviero, Guido Dalbagni, and Matthew Nielsen
Part II: T2-4
10 Selection and perioperative management of patients undergoing radical cystectomy and urinary reconstruction 111
Robert S. Svatek and Alon Z. Weizer
11 Radical cystectomy: Techniques and outcomes 127
Siamak Daneshmand and Seth P. Lerner
12 Cystectomy in the female patient 144
Ryan Werntz, Georgios Gakis, Theresa Koppie, and Arnulf Stenzl
13 Laparoscopic/robotic radical cystectomy and urinary diversion: Outcomes 156
Kristina Wittig, Kevin Chan, Mark Kawachi, and Timothy G. Wilson
14 Robotic assisted radical cystectomy and urinary diversion: Clinical trials 167
George J.S. Kallingal, Angela B. Smith, Raj S. Pruthi, and Dipen J. Parekh
15 Role of extended lymphadenectomy 176
Eugene K. Cha, George N. Thalmann, and Bernard H. Bochner
16 Management of the urethra in the cystectomy patient 184
Kamal S. Pohar and Norm D. Smith
17 The role of radical cystectomy in patients with unresectable or regionally metastatic urothelial carcinoma of the bladder 190
Scott Delacroix Jr, Nathan Lawrentschuk, and Ashish M. Kamat
Part III: Primary bladder-sparing therapy
18 Radical transurethral resection 201
Eduardo Solsona and Harry W. Herr
19 Partial cystectomy 212
Ahmed Haddad, Yair Lotan, and Arthur I. Sagalowsky
20 Integrating chemotherapy and radiotherapy for bladder cancer 221
Lior Z. Braunstein, William U. Shipley, Nicholas D. James, Andrea B. Apolo, and Jason A. Efstathiou
Part IV: Urinary tract reconstruction
21 Orthotopic neobladder 235
Eila C. Skinner
22 Continent cutaneous diversion 244
Andreas Neisius and Joachim W. Thüroff
23 Non?]continent urinary diversion 258
Michael Rink, Fredrik Liedberg, and Margit Fisch
Part V: Treatment of regionally advanced and metastatic bladder cancer
24 Molecular determinants of chemotherapy response 273
Matthew I. Milowsky, Peter H. O'Donnell, Thomas W. Flaig, and Dan Theodorescu
25 Neoadjuvant chemotherapy in the treatment of muscle-invasive bladder cancer 284
David I. Quinn and Cora N. Sternberg
26 Adjuvant chemotherapy for invasive bladder cancer 295
André P. Fay, Jeffrey J. Leow, and Joaquim Bellmunt
27 Treatment of metastatic bladder cancer 304
Gopa Iyer, Fabio Calabró, and Dean F. Bajorin
28 Treatment of poor risk patients 320
Maria De Santis and Matthew D. Galsky
Part VI: Genomics and the current status of urothelial cancer
29 Molecular events in muscle?]invasive bladder cancer development 329
Jonathan Rosenberg, William Y. Kim, Jaegil Kim, and David J. Kwiatkowski
30 Cancer stem cells and intrinsic subtypes in bladder cancer 342
Keith Syson Chan and David J. McConkey
31 Multi-targeted agents in the treatment of urothelial carcinoma 353
Noah M. Hahn, Colin P.N. Dinney, and Guru Sonpavde
Part VII: Optimizing healthcare delivery
32 Patient navigation and cancer navigator programs 365
Scott M. Gilbert and Michael Porter
33 Impact of health services on compliance and outcomes 375
Heather Honoré Goltz, Marc A. Kowalkowski, G. John Chen, and David M. Latini
34 Quality of life and survivorship 384
Nihal E. Mohamed and Cheryl T. Lee
35 Bladder cancer: Healthcare delivery and third party payers 395
Seth A. Strope and John L. Gore
36 Bladder cancer patient advocacy: Creating partnerships to advance patient care research and clinical trials 402
Diane Zipursky Quale and Rick Bangs
Index 409
List of contributors
Hikmat Al-Ahmadie MD
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Andrea B. Apolo MD
Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Jessie L.S. Au PharmD, PhD
Chief Scientific Officer, Optimum Therapeutics, LLC, San Diego, CA, USA; Henry D & Ida Mosier Chair of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, OK, USA; Adjunct Professor of Surgery, Medical University of South Carolina, Charleston, SC, USA; Adjunct Professor of Medicine, Taipei Medical University, Taiwan; Distinguished University Professor Emeritus, The Ohio State University, Columbus, OH, USA
Dean F. Bajorin MD
Weill Cornell Medical College, New York, NY, USA
Rick Bangs MD, MS
BCAN, SWOG, and NCI Patient Advocate, Rochester Hills, MI, USA
Joaquim Bellmunt MD
Bladder Cancer Center, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA, USA; University Hospital del Mar-IMIM, Barcelona, Spain
Laura A. Bertrand MD
Department of Urology, University of Iowa, Iowa City, IA, USA
Bernard H. Bochner MD
Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Lior Z. Braunstein MD
Harvard Radiation Oncology Program, Boston, MA, USA
Fabio Calabró MD
Department of Medical Oncology, San Camillo Forlanini Hospitals, Rome, Italy
Eugene K. Cha
Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Kevin Chan MD
Division of Urology and Urologic Oncology, City of Hope National Medical Center, Duarte, CA, USA
G. John Chen
Division of Health Services Research, University of Kansas School of Medicine, Kansas City, KS, USA
Guido Dalbagni MD
Attending Surgeon, Department of Urology, Memorial Sloan-Kettering Cancer Center, and Professor of Urology, Weill Cornell Medical College, New York, NY, USA
Siamak Daneshmand MD
USC Institute of Urology, USC/Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Maria De Santis MD
Ludwig Boltzmann Institute for Applied Cancer Research (LBI-ACR VIEnna) and Applied Cancer Research - Institution for Translational Oncology Vienna (ACR-ITR VIEnna) - KFJ Hospital, Vienna, Austria
Scott Delacroix, Jr MD
Assistant Professor, Department of Urology, Louisiana State University School of Medicine, New Orleans, LA, USA
Colin P.N. Dinney MD
Professor, Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Jason A. Efstathiou MD
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
André P. Fay MD
Bladder Cancer Center, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA, USA
Margit Fisch MD
Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Thomas W. Flaig MD
Department of Medicine, Division of Medical Oncology, University of Colorado Denver, and University of Colorado Cancer Center, Aurora, CO, USA
Georgios Gakis
Department of Urology, University Hospital Tübingen, Tübingen, Germany
Matthew D. Galsky MD
Associate Professor of Medicine; Director of Genitourinary Medical Oncology, Icahn School of Medicine at Mount Sinai, and The Tisch Cancer Institute, New York, NY, USA
Nilay M. Gandhi MD
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
J.M. Gaya MD
Department of Urological Oncology, Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, Spain
Scott M. Gilbert MD MS
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Heather Honoré Goltz
College of Public Service, University of Houston-Downtown, and Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
John L. Gore
Department of Urology, University of Washington, Seattle, WA, USA
Ahmed Haddad MD
Department of Urology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Noah M. Hahn MD
Associate Professor of Medicine, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA
Donna E. Hansel MD, PhD
Professor, Department of Pathology; Chief, Division of Anatomic Pathology, University of California, San Diego, La Jolla, CA, USA
Harry W. Herr MD
Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Gopa Iyer MD
Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Nicholas D. James MBBS, PhD
School of Cancer Sciences, University of Birmingham, Birmingham, UK
George J.S. Kallingal MD, MPH
Clinical Instructor, Department of Urology, University of Miami, Miami, FL, USA
Ashish M. Kamat MD
Associate Professor, Department of Urology, MD Anderson Cancer Center, Houston, TX, USA
Mark Kawachi MD
Division of Urology and Urologic Oncology, City of Hope National Medical Center, Duarte, CA, USA
Jaegil Kim MD
Broad Institute of Harvard and MIT, Cambridge, MA, USA
William Y. Kim MD
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Tobias Klatte
Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
Badrinath Konety
Department of Urology, University of Minnesota, Minneapolis, MN, USA
Theresa Koppie
Department of Urology, University Hospital Tübingen, Tübingen, Germany
Marc A. Kowalkowski
Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA
David J. Kwiatkowski MD
Broad Institute of Harvard and MIT, Cambridge, MA, USA and Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Donald L. Lamm MD
Clinical Professor, University of Arizona; Director, BCG Oncology, Phoenix, AZ, USA
David M. Latini PhD
Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA
Nathan Lawrentschuk MD
University of Melbourne, Department of Surgery; Olivia Newton-John Cancer Research Institute, Austin Hospital and Peter MacCallum Cancer Centre, Division of Cancer Surgery, Melbourne, Australia
Cheryl T. Lee MD
Department of Urology, University of Michigan, Ann Arbor, MI, USA
Seth P. Lerner MD, FACS
Department of Urology, Baylor College of Medicine, Houston, TX, USA
Jeffrey J. Leow MD
Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Urology, Tan Tock Seng Hospital, Singapore
Joseph C. Liao
Department of Urology, Stanford University School of Medicine, Stanford, CA, USA
Fredrik Liedberg MD
Department of Urology, Lund University, Malmö, Sweden
Jen-Jane Liu
Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA
Yair Lotan MD
Department of Urology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
David J. McConkey MD
Departments of Urology and Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Edward M. Messing MD, FACS
W.W. Scott Professor and Chairman, Department of Urology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
Matthew I. Milowsky MD
Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, and Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA
Nihal E. Mohamed
Department of Urology and Oncological Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Andreas Neisius MD
Department of Urology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
Matthew Nielsen MD, MS
Assistant Professor, Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Michael A. O'Donnell MD
Professor and Director of Urologic Oncology, Department of Urology, University of Iowa, Iowa City, IA, USA
Peter H....
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