
Metabolic Engineering
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Persons
Jens Nielsen is Professor and Director to Chalmers University of Technology (Sweden) since 2008. He obtained an MSc degree in Chemical Engineering and a PhD degree (1989) in Biochemical Engineering from the Technical University of Denmark (DTU) and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU, he founded and directed the Center for Microbial Biotechnology. Jens Nielsen has published more than 350 research papers, co-authored more than 40 books and he is inventor of more than 50 patents. He has founded several companies that have raised more than 20 million in venture capital. He has received numerous Danish and international awards and is member of the Academy of Technical Sciences (Denmark), the National Academy of Engineering (USA), the Royal Danish Academy of Science and Letters, the American Institute for Medical and Biological Engineering and the Royal Swedish Academy of Engineering Sciences.
Professor Gregory Stephanopoulos is the W. H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He received his BS degree from the National Technical University of Athens and his PhD from the University of Minnesota (USA). He has co-authored approximately 400 research papers and 50 patents, along with the first textbook on Metabolic Engineering. He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003 he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.
Content
1 Metabolic Engineering Perspectives
2 Genome-Scale Models: Two Decades of Progress and a 2020 Vision
3 Quantitative Metabolic Flux Analysis Based on Isotope Labeling
4 Proteome Constraints in Genome-Scale Models
5 Kinetic Models of Metabolism
6 Metabolic Control Analysis
7 Thermodynamics of Metabolic Pathways
8 Pathway Design
9 Metabolomics
10 Genome Editing of Eukarya
Part II - Applications
11 Metabolic Engineering of Escherichia coli
12 Metabolic Engineering of Corynebacterium glutamicum
13 Metabolic Engineering of Bacillus - New Tools, Strains, and Concepts
14 Metabolic Engineering of Pseudomonas
15 Metabolic Engineering of Lactic Acid Bacteria
16 Metabolic Engineering and the Synthetic Biology Toolbox for Clostridium
17 Metabolic Engineering of Filamentous Actinomycetes
18 Metabolic Engineering of Yeast
19 Harness Yarrowia lipolytica to Make Small Molecule Products
20 Metabolic Engineering of Filamentous Fungi
21 Metabolic Engineering of Photosynthetic Cells ? in Collaboration with Nature
22 Metabolic Engineering for Large-Scale Environmental Bioremediation
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