LC/MS Applications in Drug Development

Breakthroughs in combinatorial chemistry and molecular biology, aswell as an overall industry trend toward accelerated development,mean the rate of sample generation now far exceeds the rate ofsample analysis in the pursuit of producing new and betterpharmaceuticals. LC/MS is an analytical tool that helps theresearcher identify the most promising sample early in theselection process, effectively creating a shortcut to finding newdrugs. This book is the first to describe LC/MS applications withinthe context of drug development, including the discovery,preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool,LC/MS Applications in Drug Development providesperspective on the significant changes in strategies forpharmaceutical analysis. A process overview of drug developmentfrom an analytical point of view is provided along with essentialdata required to successfully bring a drug to market. Theincorporation of LC/MS is illustrated from target to product.Chapters pertaining to the discovery process itself include: * Proteomics * Glycoprotein Mapping * Natural Products Dereplication * Lead Identification Screening * Open-Access LC/MS * In Vitro Drug Screening Written for both the analytical chemist who uses LC/MSapplications and the pharmaceutical scientist who works with thedrugs they produce, LC/MS Applications in DrugDevelopment is the premier reference on the subject.