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Applications of Nuclear and Radiochemistry is a collection of articles focusing on contemporary applied research on radioactive isotopes. The monograph is based on the Second Chemical Congress of the North American Continent, held at Las Vegas, Nevada in August 1980. The book contains articles on developments in nuclear chemistry and radiochemistry, emphasizing the topic of radiopharmaceutical chemistry. The text is composed of two parts, wherein the first part is comprised of papers dealing with advances in the production of radionuclides for nuclear medicine, in the synthesis of labeled pharmaceuticals, and in the design and use of specific diagnostic agents. These sections cover research areas on machines used for research, such as compact accelerators, positron emission, and single photon tomographs. Emphasis is given to the radiochemistry and design of radiopharmaceuticals for receptor studies and for determining physiological function and metabolism of the brain, heart, and tumors. The second part examines contemporary advances including the impact of radiochemistry in China pertaining to the fallout from Chinese nuclear tests. This part also contains a section covering a list of uncommon topics. The text is of interest to nuclear scientists, academicians in the field of radiology and radiochemistry, researchers in nuclear medicine, nuclear engineers, and environmental researchers.
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978-1-4831-6230-0 (9781483162300)
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ForewordPrefaceContributing Authors1. IntroductionPart I. Radiopharmaceutical Chemistry Radionuclide Production and Generators 2. Production and Radiochemical Process Control for Short-Lived Medical Radionuclides 3. Production and Use of 13N Gases and Aerosols 4. Research-Scale Experimentation on the Production and Purification of Spallogenic 68Ge at Los Alamos for Nuclear Medicine Applications 5. Production and Purification of 52Fe 6. Biomedical Positron Generators 7. 202Pb/202Tl: A Permanent Radioactivity Reference and Minigenerator For 202T1 8. A New 1910S-191mIr Radionuclide Generator for First Pass Angiography 9. A Commercial Viewpoint for the Production of Radiopharmaceuticals Radiopharmaceutical Synthesis and Labeling 10. Bifunctional Chelating Agents: Linking Radiometals to Biological Molecules 11. Radiolabeled Blood Cells: Agents for Diagnostic and Kinetic Studies 12. The Use of 99Tc and 99mTc in the Development and Characterization of New Radiotracers for Diagnostic Nuclear Medicine 13. The Inorganic Chemistry of 99mxc Myocardial Imaging Agents 14. Kit for In Vitro Labeling of Red Blood Cells with 99mTc 15. Organic Synthesis Involving 18F 16. Synthesis and Initial Evaluation of a Cimetidine Analog Labeled with 75Se 17. Rapid and Mild Syntheses of Radioiodinated Estrogen Derivatives via Organoborane Technology 18. Radioiodine-Labeled Amines as Brain Imaging Agents 19. Activable Tracers in the Study of Aerosol Deposition and Distribution in In Lung Radiopharmaceutical Design 20. The Design of Potential Radiopharmaceuticals Based on Structure-Activity Relationships 21. Cerebral Functional Activity Mapped with 18F-2-Deoxy-2-Fluoro-D-Glucose 22. 11C-Radiopharmaceuticals for Brain Receptor Studies in Conjunction with Positron Emission Tomography 23. Radiotracers for Cerebral Blood Flow and Positron Emission Tomography 24. The Development of Muscarine Cholinergic Receptor-Binding Radiotracers 25. A Comparison of 0-(2-Iodobenzoyl)-Choline and 0-(2-Iodobenzoyl)-ß-Methyl Choline as Radiotracers for Myocardial Studies 26. Estrogen Receptor-Based Agents for Imaging Breast Tumors: Binding Selectivity as a Basis for Design and Optimization 27. Radioactive Labeling of Fatty Acids for Metabolic Studies 28. The Influence of Chain Length on the Myocardial Uptake of 75Se-Labeled Fatty Acids 29. The Mechanism of Tumor Localization of Gallium: An Update and ReassessmentPart II. Contemporary Advances Impact of Radiochemistry in China 30. Photoreduction of the Uranyl Ion in an Aqueous Sulfuric and Ethanol Solution with a CW He-Cd Laser: Quantum Yield and Apparent Rate 31. A Study of Some Complex Compounds of Uranyl and Thorium Salts with Crown Ether 32. Analogue Study for Recovery of Am and Cm from the High Level Waste of Reactor Fuel with High Pressure Chromatography. Part 1. Steady-State Migration Rate of the Band. Part 2. The Composition of the Steady Zone 33. Separation of Rb and Cs by Extraction Ion Exchange 34. Determination of Light Elements in High Purity Materials by Charged Particle Activation Analysis 35. The Origin of Excess Polonium-210 in Natural Waters 36. The Measurement of Airborne Radionuclides Over Japan Since 1974 37. Use of Radioactive Isotopes as Atmospheric Tracers Nuclear Probes 38. Application of Hot Atom Chemistry Techniques as an Indicator of Solute-Solute Interactions in Liquid and Frozen Water 39. Recovery of Underexposed Images by Autoradiographic Intensification Method 40. Radioactive and Stable Isotopes in the Early Solar System 41. Muonium Spin Rotation Applications to Model Biological Systems 42.