High-Throughput Lead Optimization in Drug Discovery
1st Edition
Published on 4. March 2008
256 pages
978-1-4200-0696-4 (ISBN)
Description
A Single Source on Parallel Synthesis for Lead Optimization
The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit
The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit
Reviews / Votes
"Overall, this book is a successful attempt to provide in one volume many illustrative examples in this evolving field and it presents a wealth of information on topics that demonstrate the versatility and power of the technology."- Jan W. F. Wasley, Simpharma LLC, in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 23
More details
Series
Edition
1. Auflage
Language
English
Place of publication
Baton Rouge
United States
Publishing group
Taylor & Francis Inc
Target group
Professional and scholarly
Medicinal and combinatorial chemists in the pharmaceutical and biotechnology industries.
Illustrations
177 s/w Abbildungen, 37 s/w Tabellen
177 b/w images and 37 tables
File size
9,89 MB
ISBN-13
978-1-4200-0696-4 (9781420006964)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Tushar Kshirsagar
High-Throughput Lead Optimization in Drug Discovery
Book
09/2019
1st Edition
CRC Press
€93.50
Shipment within 15-20 days
Tushar Kshirsagar
High-Throughput Lead Optimization in Drug Discovery
Book
03/2008
1st Edition
CRC Press
€248.01
Shipment within 15-20 days
Person
Content
Introduction and Review. Application of Parallel Synthesis to the Optimization of Inhibitors of the ZipA-FtsZ Protein-Protein Interaction. Case Studies of Parallel Synthesis in Hit Identification, Hit Exploration, Hit-to-Lead, and Lead Optimization Programs. A Successful Application of Parallel Synthesis to Computer-Assisted Structural Optimization of New Leads Targeting Human Immunodeficiency Virus-1 Reverse Transcriptase: The Case of Acylthiocarbamates and Thiocarbamates. How High-Throughput Medicinal Chemistry Can Expedite Lead Discovery, Lead Optimization, and Beyond. Rapid Lead Identification of Inhibitors of Adenine Nucleotide Translocase: A Case Study of Applying Combinatorial Chemistry Techniques in Drug Discovery. Parallel Synthesis of Anticancer, Antiinflammatory, and Antiviral Agents Derived from L-and D-Amino Acids. Application of Solid-Phase Parallel Synthesis in Lead Optimization Studies. High-Throughput Solid-Phase Synthesis of Nucleoside-Based Libraries in the Search for New Antibiotics.
