Computational Systems Biology
From Molecular Mechanisms to Disease
2nd Edition
Published on 26. November 2013
548 pages
978-0-12-405938-2 (ISBN)
Description
This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling.
- Logical information flow aids understanding of basic building blocks of life through disease phenotypes
- Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns
- Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation
- Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
More details
Other editions
Additional editions
Book
01/2014
2nd Edition
Academic Press
€135.50
Shipment within 15-20 days
Previous edition
Andres Kriete | Roland Eils
Computational Systems Biology
E-Book
11/2005
1st Edition
Academic Press
from
€155.00
Available for download
Content
Introducing Computational Systems Biology; Protein Interactions, Stability and Regulation; Transcriptional control; Introduction to Computational Models of Biochemical Reaction Networks; Biological Foundations of Signal Transduction and Aberrations in Disease; A discrete approach to top-down modeling of biochemical networks; Reconstruction of metabolic network from genome information and its structural and functional analysis; Gene networks: estimation, modeling and simulation; Standards, platforms and tools; Computational models for circadian rhythms: Deterministic versus stochastic approaches; Integrated imaging informatics; Imaging and Modeling of complex tumor formation; Imaging to help decipher an model higher orders of complexity; Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks; Whole Cell Modeling; Databases for Systems Biology; Systems Biology of the Microbiome; Systems Immunology; Applying systems biology to understand the immune response to infection and vaccination; Aging and Systems Biology; From Cardiac Mitochondria to Systems Physiology; Cancer Systems Biology; Systems Medicine, Drug Biology and Interventions; Towards a blueprint of an entire organism
