Kinomics
Approaches and Applications
1st Edition
Published on 11. August 2015
368 pages
978-3-527-68305-5 (ISBN)
Description
Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field.
Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown.
The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown.
The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
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Persons
Heinz-Bernhard Kraatz received his Ph.D. from the University of Calgary in 1993. He is a Professor of Chemistry in the Department of Physical and Environmental Sciences and the Department of Chemistry at the University of Toronto. He received a number of awards for his work in biological chemistry. His research is focused on the design surface-supported functional bioconjugates for the study of biological interactions and enzymatic activities including protein kinase catalyzed phosphorylations. His current research interests are in the area of biomaterials and biochemical transformations and analysis.
Sanela Martic is an Assistant Professor of Chemistry at Oakland University, USA, since 2012. Dr. Martic received her Ph.D. degree in 2009 from Queen's University at Kingston, under the supervision of Prof. Suning Wang and co-supervision of Prof. Gang Wu. Her Ph.D. dissertation was on the synthesis of fluorescent nucleosides and their self-assembly. Jointly with her colleague, Heinz-Bernhard Kraatz, she focused on the synthesis of the redox active bioconjugates for protein kinase phosphorylations. Her current research interests include the self-assembly of peptides and proteins towards new biomaterials and bioanalytical methods.
Sanela Martic is an Assistant Professor of Chemistry at Oakland University, USA, since 2012. Dr. Martic received her Ph.D. degree in 2009 from Queen's University at Kingston, under the supervision of Prof. Suning Wang and co-supervision of Prof. Gang Wu. Her Ph.D. dissertation was on the synthesis of fluorescent nucleosides and their self-assembly. Jointly with her colleague, Heinz-Bernhard Kraatz, she focused on the synthesis of the redox active bioconjugates for protein kinase phosphorylations. Her current research interests include the self-assembly of peptides and proteins towards new biomaterials and bioanalytical methods.
Content
PART 1: Protein Kinases Cell Signaling
'Genuine' Casein Kinase (Fam20C): The Mother of the Phospho-Secretome
Chemical Biology of Protein Kinas
Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis
The Kinomics of Malaria
PART 2: ATP Co-Substrate Design
ATP Analogs in Kinase Research
Electrochemical Detection of Protein Kinase Catalyzed Phosphorylations
PART 3: New Methodologies for Kinomics
Phos-tag Technology for Kinomics
Development of Species- and Process-Specific Peptide Kinome Arrays with Priority Application to Investigations of Infectious Disease
New Approaches to Understanding Bacterial Histidine Kinase Activity and Inhibition
Methods for Large-Scale Identification of Protein Kinase-Substrate Networks
PART 4: Kinase Inhibition
Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease
Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands
'Genuine' Casein Kinase (Fam20C): The Mother of the Phospho-Secretome
Chemical Biology of Protein Kinas
Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis
The Kinomics of Malaria
PART 2: ATP Co-Substrate Design
ATP Analogs in Kinase Research
Electrochemical Detection of Protein Kinase Catalyzed Phosphorylations
PART 3: New Methodologies for Kinomics
Phos-tag Technology for Kinomics
Development of Species- and Process-Specific Peptide Kinome Arrays with Priority Application to Investigations of Infectious Disease
New Approaches to Understanding Bacterial Histidine Kinase Activity and Inhibition
Methods for Large-Scale Identification of Protein Kinase-Substrate Networks
PART 4: Kinase Inhibition
Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease
Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands
List of Contributors
- Soha Ahmadi
- University of Toronto
- Department of Chemistry
- St. George Street
- M5S 3H6 Toronto
- Canada
- and
- University of Toronto Scarborough
- Department of Physical and Environmental Sciences
- Military Trail
- Toronto, ON M1C 1A
- Canada
- Margaux Airey
- University of Auckland
- School of Chemical Sciences
- Symonds Street
- Private Bag 92019
- Auckland
- New Zealand
- Thilani M. Anthony
- Wayne State University
- Department of Chemistry
- Cass Avenue
- Detroit, MI 48202
- USA
- Ryan Arsenault
- United States Department of Agriculture
- Agricultural Research Service
- SPARC
- College Station, 2881 F&B Road
- TX 77845
- USA
- Maria V. Babak
- University of Auckland
- School of Chemical Sciences
- Symonds Street
- Private Bag 92019
- Auckland
- New Zealand
- Daniel P. Ball
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- Oliver Billker
- Wellcome Trust Sanger Institute
- Malaria programme Hinxton
- CB10 1SA Cambridge
- UK
- Mathieu Brochet
- Wellcome Trust Sanger Institute
- Malaria programme Hinxton
- CB10 1SA Cambridge
- UK
- and
- UMR 5235
- iDynamique des interactions membranaires normales et pathologiques
- CNRS-Université Montpellier 2
- Eugéne Bataillon
- Montpellier
- France
- Erin E. Carlson
- Indiana University
- Department of Chemistry
- East Kirkwood Avenue
- Bloomington, IN 47405
- USA
- and
- University of Minnesota
- Department of Chemistry
- Pleasant St. SE
- Minneapolis
- MN 55455
- USA
- Giorgio Cozza
- University of Padova
- Institute of Neuroscience
- Department of Biomedical Sciences, CNR
- Via Ugo Bassi 58/B 35131
- Padova
- Italy
- Pavithra M. Dedigama-Arachchige
- Wayne State University
- Department of Chemistry
- Cass Avenue
- Detroit, MI 48202
- USA
- Jack E. Dixon
- University of California
- Department of Pharmacology
- San Diego
- La Jolla
- CA 92093
- USA
- Christian Doerig
- Monash University
- Department of Microbiology
- School of Biomedical Sciences
- Innovation Walk
- Clayton
- Victoria
- Australia
- D Maheeka Embogama
- Wayne State University
- Department of Chemistry
- Cass Avenue
- Detroit, MI 48202
- USA
- Todd R. Faner
- Wayne State University
- Department of Chemistry
- Cass Avenue
- Detroit, MI 48202
- USA
- Ahmed E. Fouda
- Wayne State University
- Department of Chemistry
- Cass Avenue
- Detroit, MI 48202
- USA
- Rodolfo F. Gómez-Biagi
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- Jennifer L. Gorman
- Lunenfeld-Tanenbaum Research Institute
- Mount Sinai Hospital
- University Avenue
- Toronto, ON, M5G 1X5
- Canada
- Patrick T. Gunning
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- Christian G. Hartinger
- University of Auckland
- School of Chemical Sciences
- Symonds Street
- Private Bag 92019
- Auckland
- New Zealand
- KassaDee J. Ketelaar
- University of Nevada
- Department of Biochemistry and Molecular Biology
- North Virginia St. MS0330
- Reno, NV 89557
- USA
- Eiji Kinoshita
- Hiroshima University
- Institute of Biomedical & Health Sciences
- Department of Functional Molecular Science
- Kasumi 1-2-3
- 734-8553 Hiroshima
- Japan
- Emiko Kinoshita-Kikuta
- Hiroshima University
- Institute of Biomedical & Health Sciences
- Department of Functional Molecular Science
- Kasumi 1-2-3
- 734-8553 Hiroshima
- Japan
- Tohru Koike
- Hiroshima University
- Department of Functional Molecular Science
- Institute of Biomedical & Health Sciences
- Kasumi 1-2-3
- 734-8553 Hiroshima
- Japan
- Heinz-Bernhard Kraatz
- University of Toronto
- Department of Chemistry
- St. George Street
- M5S 3H6 Toronto
- Canada
- and
- University of Toronto Scarborough
- Department of Physical and Environmental Sciences
- Military Trail
- Toronto, ON M1C 1A
- Canada
- Anthony Kusalik
- University of Saskatchewan
- Department of Computer Science
- Science Place
- S7N 5C9, Saskatoon, SK
- Canada
- Ping-Shan Lai
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- Andrew M. Lewis
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- David W. Litchfield
- University of Western Ontario
- Department of Biochemistry
- Schulich School of Medicine & Dentistry
- N6A 5C1 London, ON
- Canada
- David Mann
- Imperial College London
- Faculty of Natural Sciences
- Department of Life Sciences
- South Kensington Campus
- SW7 2AZ London
- UK
- Sanela Martic
- Oakland University
- Department of Chemistry
- North Squirrel Road
- Rochester, MI 48309
- USA
- Scott Napper
- University of Saskatchewan
- Department of Biochemistry
- Wiggins Road
- S7N 5E5 Saskatoon, SK
- Canada
- and
- University of Saskatchewan
- Vaccine and Infectious Disease Organization-InterVac
- Veterinary Road
- S7N 5E3 Saskatoon, SK
- Canada
- Ji Sung Park
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- Mary Kay H. Pflum
- Wayne State University
- Department of Chemistry
- Cass Avenue
- Detroit, MI 48202
- USA
- Lorenzo A. Pinna
- University of Padova
- Institute of Neuroscience
- Department of Biomedical Sciences, CNR
- Via Ugo Bassi 58/B 35131
- Padova
- Italy
- Rahul Rana
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- David Rosa
- University of Toronto
- Department of Chemical and Physical Sciences
- Mississauga Road North
- L5L 1C6 Mississauga, ON
- Canada
- Zhe She
- University of Toronto
- Department of Chemistry
- St. George Street
- M5S 3H6 Toronto
- Canada
- and
- University of Toronto Scarborough
- Department of Physical and Environmental Sciences
- Military Trail
- Toronto, ON M1C 1A
- Canada
- Vincent S. Tagliabracci
- University of California
- Department of Pharmacology
- San Diego
- La Jolla
- CA 92093
- USA
- Andrew B. Tobin
- University of Leicester
- MRC Toxicology Unit
- Lancaster Road
- LE1 9HN Leicester
- UK
- Brett Trost
- University of Saskatchewan
- Department of Computer Science
- Science Place
- S7N 5C9 Saskatoon, SK
- Canada
- Ian S. Wallace
- University of Nevada
- Department of Biochemistry and Molecular Biology
- North Virginia St. MS0330
- Reno, NV 89557
- USA
- Kaelyn E. Wilke
- Indiana University
- Department of Chemistry
- East Kirkwood Avenue
- Bloomington, IN 47405
- USA
- James R. Woodgett
- Lunenfeld-Tanenbaum Research Institute
- Mount Sinai Hospital
- University Avenue
- Toronto, ON, M5G 1X5
- Canada
- and
- University of Toronto
- Department of Medical Biophysics
- Toronto, ON
- Canada
- Stephanie A. Zukowski
- University of Western Ontario
- Department of Biochemistry
- Schulich...
