Kinomics
Approaches and Applications
1st Edition
Published on 4. August 2015
368 pages
978-3-527-68304-8 (ISBN)
Description
Authored by the world's leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field.
Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown.
The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown.
The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.
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Persons
Heinz-Bernhard Kraatz received his Ph.D. from the University of Calgary in 1993. He is a Professor of Chemistry in the Department of Physical and Environmental Sciences and the Department of Chemistry at the University of Toronto. He received a number of awards for his work in biological chemistry. His research is focused on the design surface-supported functional bioconjugates for the study of biological interactions and enzymatic activities including protein kinase catalyzed phosphorylations. His current research interests are in the area of biomaterials and biochemical transformations and analysis.
Sanela Martic is an Assistant Professor of Chemistry at Oakland University, USA, since 2012. Dr. Martic received her Ph.D. degree in 2009 from Queen's University at Kingston, under the supervision of Prof. Suning Wang and co-supervision of Prof. Gang Wu. Her Ph.D. dissertation was on the synthesis of fluorescent nucleosides and their self-assembly. Jointly with her colleague, Heinz-Bernhard Kraatz, she focused on the synthesis of the redox active bioconjugates for protein kinase phosphorylations. Her current research interests include the self-assembly of peptides and proteins towards new biomaterials and bioanalytical methods.
Sanela Martic is an Assistant Professor of Chemistry at Oakland University, USA, since 2012. Dr. Martic received her Ph.D. degree in 2009 from Queen's University at Kingston, under the supervision of Prof. Suning Wang and co-supervision of Prof. Gang Wu. Her Ph.D. dissertation was on the synthesis of fluorescent nucleosides and their self-assembly. Jointly with her colleague, Heinz-Bernhard Kraatz, she focused on the synthesis of the redox active bioconjugates for protein kinase phosphorylations. Her current research interests include the self-assembly of peptides and proteins towards new biomaterials and bioanalytical methods.
Content
PART 1: Protein Kinases Cell Signaling
'Genuine' Casein Kinase (Fam20C): The Mother of the Phospho-Secretome
Chemical Biology of Protein Kinas
Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis
The Kinomics of Malaria
PART 2: ATP Co-Substrate Design
ATP Analogs in Kinase Research
Electrochemical Detection of Protein Kinase Catalyzed Phosphorylations
PART 3: New Methodologies for Kinomics
Phos-tag Technology for Kinomics
Development of Species- and Process-Specific Peptide Kinome Arrays with Priority Application to Investigations of Infectious Disease
New Approaches to Understanding Bacterial Histidine Kinase Activity and Inhibition
Methods for Large-Scale Identification of Protein Kinase-Substrate Networks
PART 4: Kinase Inhibition
Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease
Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands
'Genuine' Casein Kinase (Fam20C): The Mother of the Phospho-Secretome
Chemical Biology of Protein Kinas
Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis
The Kinomics of Malaria
PART 2: ATP Co-Substrate Design
ATP Analogs in Kinase Research
Electrochemical Detection of Protein Kinase Catalyzed Phosphorylations
PART 3: New Methodologies for Kinomics
Phos-tag Technology for Kinomics
Development of Species- and Process-Specific Peptide Kinome Arrays with Priority Application to Investigations of Infectious Disease
New Approaches to Understanding Bacterial Histidine Kinase Activity and Inhibition
Methods for Large-Scale Identification of Protein Kinase-Substrate Networks
PART 4: Kinase Inhibition
Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease
Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands
